There are currently 27 active clinical trials seeking participants for Endometriosis research studies. The states with the highest number of trials for Endometriosis participants are Florida, Texas, California and Ohio.
Evaluation of Endometriosis With 18F-fluorofuranylnorprogesterone PET / MRI
NCT05480995
Recruiting
Purpose: The aim of this study is to assess the sensitivity and specificity of FFNP PET/MRI for diagnosis of endometriosis. Participants: A total of 24 participants will be recruited from individuals with clinically suspected endometriosis. Procedures (methods): This is a prospective, one arm, single center study of 24 subjects with clinically suspected endometriosis to demonstrate FFNP PET-MRI's clinical utility for diagnosis of endometriosis.
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
01/21/2025
Locations: University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Conditions: Endometriosis
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Endometriosis Pain
NCT06101303
Recruiting
Aim 1. To determine the factors contributing to pain in patients with chronic pelvic pain with and without endometriosis Aim 2. To determine the changes following endometriosis lesion removal surgery in pain and sex hormone levels. Aim 3. To identify factors predicting clinical pain reduction after lesion removal surgery. Additional exploratory aims might compare subgroups of patients such as patients with vs. without endometriosis, with vs. without additional chronic pain syndromes, and with... Read More
Gender:
FEMALE
Ages:
Between 12 years and 45 years
Trial Updated:
01/14/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Pelvic Pain, Endometriosis
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The Effect of Medical Management Following Excisional Surgery for Endometriosis: A Randomized Controlled Trial
NCT06439524
Recruiting
The goal of this investigator-initiated single-site clinical trial is to compare the overall quality of life of participants taking Relugolix combination therapy (Rel-CT) following excisional surgery for endometriosis to participants that do not take Rel-CT following the same surgery. Rel-CT is an FDA approved form of medical treatment for endometriosis. It is known to work in treating endometriosis pain. However, investigators do not know whether or not there is a benefit to beginning Rel-CT im... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Main Line Health, Wynnewood, Pennsylvania
Conditions: Endometriosis
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Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer
NCT04567771
Recruiting
This early phase I trial compares the side effects between patients treated with proton radiation therapy versus intensity modulated radiation therapy after surgery for the treatment of endometrial or cervical cancer. Radiation therapy uses high energy protons or x-rays to kill tumor cells and shrink tumors. Using quality of life questionnaires and adverse event assessments may help doctors learn whether proton radiation therapy is associated with lower acute gastrointestinal toxicities at the e... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +2 locations
Conditions: Cervical Carcinoma, Endometrial Carcinoma, Endometriosis, Pelvic Inflammatory Disease
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Endometriosis and Microvascular Dysfunction: Role of Inflammation
NCT05069740
Recruiting
The purpose of this study is to better understand the underlying mechanisms associated with elevated cardiovascular disease risk in women with endometriosis, and to measure the effectiveness of emerging endometriosis treatments on outcomes specific to cardiovascular dysfunction. Epidemiologic data demonstrate a clear association between endometriosis, reproductive risk factors, inflammation and cardiovascular (CV) risk. Circulating factors, low-density lipoprotein (LDL) and oxidized LDL (oxLDL)... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/04/2024
Locations: The Pennsylvania State University, University Park, Pennsylvania
Conditions: Endometriosis
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Nutritional Intervention for Endometriosis
NCT05175248
Recruiting
In a 12-week parallel study, women with a verified diagnosis of endometriosis will be randomly assigned to follow a low-fat plant-based diet or to stay on their usual diets for 12 weeks. Participants in both groups will be asked to make no changes to their exercise patterns for the study period. Changes in pain, quality of life, and inflammatory biomarkers from baseline to final will be the primary outcomes. Secondary outcomes will include changes in body weight, blood lipids, gut microbiome com... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/04/2024
Locations: Physicians Committee for Responsible Medicine, Washington, DC, District of Columbia
Conditions: Endometriosis
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Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee
NCT05059626
Recruiting
Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis. Hypothesis: Treatment with the SERM (bazedoxifene + conjugated estrogen) or with simvastatin will decrease systemic inflammation and improve specific measures of cardiovascular function including endothelium-dependent vasodilation.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
11/04/2024
Locations: The John B. Pierce Laboratory, New Haven, Connecticut
Conditions: Endometriosis
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Use of TENS Unit in the Management of Endometriosis Pain
NCT05348005
Recruiting
The purpose of this study is see if Transcutaneous Electrical Nerve Stimulator (TENS) units help decrease endometriosis flare pain. TENS units have a 510K and are intended for relief of pain associated with sore or aching muscles of the lower back, arms, or legs due to strain from exercise or normal household and work activities. Participants will complete surveys, record pain, medication use and bleeding in an online diary during endometriosis flare ups for 3 months without using the TENS unit... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
10/30/2024
Locations: Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Endometriosis, Pelvic Pain
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A Phase 3B Study to Evaluate Bone Mineral Density with Long-Term Use of Relugolix Combination Tablet in Women with Uterine Fibroids or Endometriosis
NCT05862272
Recruiting
The purpose of this clinical trial to characterize changes in bone mineral density during continuous treatment with relugolix combination tablet for up to 48 months (4 years) and 1 year of post-treatment follow-up in premenopausal women with heavy menstrual bleeding associated with uterine leiomyomas (fibroids) or with moderate-to-severe pain associated with endometriosis.
Gender:
FEMALE
Ages:
Between 18 years and 50 years
Trial Updated:
09/24/2024
Locations: Mobile, Mobile, Alabama +92 locations
Conditions: Uterine Fibroids, Endometriosis
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A Study to Assess the Efficacy and Safety of HMI-115 in Subjects with Endometriosis-Associated Pain
NCT05101317
Recruiting
This study is designed to evaluate the safety and efficacy of HMI-115 compared to placebo over a 12 weeks period on subjects with moderate to severe endometriosis-associated pain.
Gender:
FEMALE
Ages:
Between 18 years and 49 years
Trial Updated:
09/11/2024
Locations: Physicians' Research Options, LLC- Corner Canyon Clinic, Draper, Utah +4 locations
Conditions: Endometriosis
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Superior Hypogastric Nerve Plexus Block With Bupivacaine After Robotic Resection of Endometriosis
NCT06577233
Recruiting
Endometriosis is a condition that causes significant pelvic pain and affects 10-15% of reproductive age women. Treatment options area both medical and surgical for pain relief, however with surgical options, past studies have demonstrated a higher risk of surgical complications as well as higher postoperative pain scores in women with endometriosis. Despite attempts to limit narcotic pain medications with enhanced recovery after surgery (ERAS) protocols, persistent opioid use after surgery is a... Read More
Gender:
FEMALE
Ages:
Between 18 years and 65 years
Trial Updated:
08/27/2024
Locations: Texas Childrens Hospital Pavilion for Women, Houston, Texas
Conditions: Endometriosis
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Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance
NCT03756480
Recruiting
This study will test the hypothesis that the molecular changes present in ectopic endometriosis lesions correlate with progesterone-resistant disease (using the criteria defined in this study) and are present in matched eutopic endometrium.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
08/06/2024
Locations: Yale School of Medicine, New Haven, Connecticut +2 locations
Conditions: Endometriosis, Endometrial Diseases
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