Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
NCT03844412
Recruiting
Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States. Here, the investigators plan to conduct a randomized, double-blinded, placebo-controlled clinical trial to 1) compare the efficacy of peripheral (lidocaine/estradiol cream), centrally-targeted (nortriptyline), and combined treatments in alleviating pain and improving patient-reported outcomes and 2) determine cytokine... Read More
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
11/28/2023
Locations: University of California, Los Angeles, Los Angeles, California +1 locations
Conditions: Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome, Irritable Bowel Syndrome, Migraines, Tension Headache, Endometriosis, Interstitial Cystitis, Back Pain, Chronic Fatigue Syndrome
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Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain
NCT04333576
Recruiting
Endometriosis is a painful disorder of the uterus affecting 6-10% of women of childbearing age. Endometriosis affects daily activities, social relationships, sexuality and sexual activity, and mental health. This study will evaluate how well elagolix in combination with combined oral contraceptives (COC) works within the body and/or how safe it is compared to placebo (does not contain treatment drug). This study will assess the dysmenorrhea (painful periods) response in participants with endomet... Read More
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
11/24/2023
Locations: Pinnacle Research Group /ID# 217062, Anniston, Alabama +178 locations
Conditions: Endometriosis
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Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer
NCT04567771
Recruiting
This early phase I trial compares the side effects between patients treated with proton radiation therapy versus intensity modulated radiation therapy after surgery for the treatment of endometrial or cervical cancer. Radiation therapy uses high energy protons or x-rays to kill tumor cells and shrink tumors. Using quality of life questionnaires and adverse event assessments may help doctors learn whether proton radiation therapy is associated with lower acute gastrointestinal toxicities at the e... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
11/17/2023
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +2 locations
Conditions: Cervical Carcinoma, Endometrial Carcinoma, Endometriosis, Pelvic Inflammatory Disease
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Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis
NCT04173169
Recruiting
A Phase 3 clinical trial of oral GnRH antagonist pre-treatment for women with endometriosis who are undergoing IVF, with a primary outcome of live birth rate. The investigators' central hypothesis is that in infertile woman with endometriosis undergoing in vitro fertilization-embryo transfer (IVF-ET), live birth rates will improve in those pretreated with GnRH antagonist compared to those not pretreated with GnRH antagonist.
Gender:
Female
Ages:
Between 18 years and 40 years
Trial Updated:
11/17/2023
Locations: University of Colorado Department of Obstetrics & Gynecology, Aurora, Colorado +4 locations
Conditions: Infertility, Endometriosis
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A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis
NCT05862272
Recruiting
The purpose of this clinical trial to characterize changes in bone mineral density during continuous treatment with relugolix combination tablet for up to 48 months (4 years) and 1 year of post-treatment follow-up in premenopausal women with heavy menstrual bleeding associated with uterine leiomyomas (fibroids) or with moderate-to-severe pain associated with endometriosis.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
11/10/2023
Locations: Mobile, Mobile, Alabama +38 locations
Conditions: Uterine Fibroids, Endometriosis
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Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee
NCT05059626
Recruiting
Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis. Hypothesis: Treatment with the SERM (bazedoxifene + conjugated estrogen) or with simvastatin will decrease systemic inflammation and improve specific measures of cardiovascular function including endothelium-dependent vasodilation.
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
11/07/2023
Locations: The John B. Pierce Laboratory, New Haven, Connecticut
Conditions: Endometriosis
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Nutritional Intervention for Endometriosis
NCT05175248
Recruiting
In a 12-week parallel study, women with a verified diagnosis of endometriosis will be randomly assigned to follow a low-fat plant-based diet or to stay on their usual diets for 12 weeks. Participants in both groups will be asked to make no changes to their exercise patterns for the study period. Changes in pain, quality of life, and inflammatory biomarkers from baseline to final will be the primary outcomes. Secondary outcomes will include changes in body weight, blood lipids, gut microbiome com... Read More
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
11/02/2023
Locations: Physicians Committee for Responsible Medicine, Washington, District of Columbia
Conditions: Endometriosis
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A Study to Assess the Efficacy and Safety of HMI-115 in Subjects With Endometriosis-Associated Pain
NCT05101317
Recruiting
This study is designed to evaluate the safety and efficacy of HMI-115 compared to placebo over a 12 weeks period on subjects with moderate to severe endometriosis-associated pain.
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
11/01/2023
Locations: Physicians' Research Options, LLC- Corner Canyon Clinic, Draper, Utah +4 locations
Conditions: Endometriosis
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Thromboxane Function in Women With Endometriosis
NCT05962034
Recruiting
The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: perform hand grip exercise and cold pressor tests undergo iontophoresis and blood draw Resea... Read More
Gender:
Female
Ages:
Between 18 years and 45 years
Trial Updated:
10/30/2023
Locations: Noll Laboratory, University Park, Pennsylvania
Conditions: Endometriosis
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Endometriosis Pain
NCT06101303
Recruiting
Aim 1. To determine the factors contributing to pain in patients with chronic pelvic pain with and without endometriosis Aim 2. To determine the changes following endometriosis lesion removal surgery in pain and sex hormone levels. Aim 3. To identify factors predicting clinical pain reduction after lesion removal surgery. Additional exploratory aims might compare subgroups of patients such as patients with vs. without endometriosis, with vs. without additional chronic pain syndromes, and with... Read More
Gender:
Female
Ages:
Between 12 years and 45 years
Trial Updated:
10/30/2023
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Pelvic Pain, Endometriosis
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The Use of Low Dose Metronidazole to Decrease Postoperative Pain After Endometriosis Surgery
NCT04554693
Recruiting
The purpose of this study is to determine a difference in participant reported pain after endometriosis surgery in participants given oral metronidazole versus placebo.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
10/25/2023
Locations: University of Louisville Hospital, Louisville, Kentucky
Conditions: Endometriosis, Endometriosis-related Pain
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Endometriosis Group Care
NCT05622955
Recruiting
The goal of this clinical trial is to test the effectiveness of the Peer Empowered Endometriosis Pain Support (PEEPS) program in people living with endometriosis-related pelvic pain. The main question[s] it aims to answer are: Is PEEPS effective at decreasing pain interference and improving patient-reported quality of life outcomes? What are the barriers and facilitators to PEEPS implementation? Participants will engage in eight weekly 2-hour sessions led by an endometriosis specialist, pain ps... Read More
Gender:
Female
Ages:
Between 18 years and 48 years
Trial Updated:
10/24/2023
Locations: Washington University in St. Louis, Saint Louis, Missouri
Conditions: Endometriosis, Pelvic Pain
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