There are currently 27 active clinical trials seeking participants for Endometriosis research studies. The states with the highest number of trials for Endometriosis participants are Florida, Texas, California and Ohio.
Histologic Comparison of Ablative Techniques for Endometriosis
NCT06414083
Recruiting
To our knowledge, no other human studies directly compare the effectiveness of the various ablative technologies. We set out to design a study to directly compare ablative energy sources and evaluate their ability to destroy native endometriosis tissue in humans.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/28/2024
Locations: Good Samaritan Hospital, Cincinnati, Ohio
Conditions: Endometriosis, Endometriosis-related Pain, Endometriosis Pelvic, Endometriosis; Peritoneum
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Cardiovascular Disease Risk in Women With Endometriosis
NCT03746535
Recruiting
To test the hypothesis that estrogen suppression impairs endothelial dysfunction in endometriosis.
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
05/22/2025
Locations: Yale School of Medicine, New Haven, Connecticut
Conditions: Endometriosis
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Glycemic Regulation as Endometriosis Adjunct Treatment
NCT06611501
Recruiting
The goal of this pilot trial is to learn if a novel non-hormonal treatment, metformin hydrochloride, works to treat pelvic pain in young women with endometriosis. The main questions it aims to answer are: * Is metformin superior to placebo in alleviating pain symptoms in young women with endometriosis? * Does metformin alter systemic inflammatory markers over 6 months in young women with endometriosis? Researchers will compare metformin to a placebo (a look-alike substance that contains no dru... Read More
Gender:
FEMALE
Ages:
Between 15 years and 35 years
Trial Updated:
05/22/2025
Locations: Boston Children's Hospital, Boston, Massachusetts
Conditions: Pelvic Pain, Endometriosis
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Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups
NCT06974773
Recruiting
The goal of this clinical trial is to learn if a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve wellbeing in women with endometriosis. The study also aims to assess the safety and usability of the device when used at home over several months. The main questions it aims to answer are: 1. Does at-home transcranial direct current stimulation (tDCS) reduce daily pain intensity in women with endometriosis? 2. Does the device also improve mood and slee... Read More
Gender:
FEMALE
Ages:
Between 22 years and 45 years
Trial Updated:
05/21/2025
Locations: Alethios, Inc., San Francisco, California
Conditions: Endometriosis
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The Effect of Medical Management Following Excisional Surgery for Endometriosis: A Randomized Controlled Trial
NCT06439524
Recruiting
The goal of this investigator-initiated single-site clinical trial is to compare the overall quality of life of participants taking Relugolix combination therapy (Rel-CT) following excisional surgery for endometriosis to participants that do not take Rel-CT following the same surgery. Rel-CT is an FDA approved form of medical treatment for endometriosis. It is known to work in treating endometriosis pain. However, investigators do not know whether or not there is a benefit to beginning Rel-CT im... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
05/20/2025
Locations: Main Line Health, Wynnewood, Pennsylvania
Conditions: Endometriosis
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Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain
NCT04333576
Recruiting
Endometriosis is a painful disorder of the uterus affecting 6-10% of women of childbearing age. Endometriosis affects daily activities, social relationships, sexuality and sexual activity, and mental health. This study will evaluate how well elagolix in combination with combined oral contraceptives (COC) works within the body and/or how safe it is compared to placebo (does not contain treatment drug). This study will assess the dysmenorrhea (painful periods) response in participants with endomet... Read More
Gender:
FEMALE
Ages:
Between 18 years and 49 years
Trial Updated:
05/07/2025
Locations: Pinnacle Research Group /ID# 217062, Anniston, Alabama +178 locations
Conditions: Endometriosis
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Thromboxane Function in Women With Endometriosis
NCT05962034
Recruiting
The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: * Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? * Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: * perform hand grip exercise and cold pressor tests * undergo iontophoresis and blood dra... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
05/02/2025
Locations: Noll Laboratory, University Park, Pennsylvania
Conditions: Endometriosis
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Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer
NCT04567771
Recruiting
This early phase I trial compares the side effects between patients treated with proton radiation therapy versus intensity modulated radiation therapy after surgery for the treatment of endometrial or cervical cancer. Radiation therapy uses high energy protons or x-rays to kill tumor cells and shrink tumors. Using quality of life questionnaires and adverse event assessments may help doctors learn whether proton radiation therapy is associated with lower acute gastrointestinal toxicities at the e... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +2 locations
Conditions: Cervical Carcinoma, Endometrial Carcinoma, Endometriosis, Pelvic Inflammatory Disease
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Endometriosis and Migraine
NCT06785129
Recruiting
This study aims to determine differences in experimental pain and sex hormone levels between patients with migraine, patients with endometriosis, patients with migraine and endometriosis, and healthy controls. Participants will complete surveys, experimental pain paradigms and collection of samples for hormone analyses.
Gender:
FEMALE
Ages:
Between 12 years and 45 years
Trial Updated:
03/26/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri
Conditions: Migraine, Endometriosis
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Cabergoline for the Treatment of Chronic Pain Due to Endometriosis
NCT03928288
Recruiting
Endometriosis is dependent on angiogenesis (the sprouting of new blood vessels) for its growth and maintenance, but the side effects of currently approved angiogenesis inhibitors make these agents inappropriate for use in reproductive-age patients. This obstacle will be overcome by performing a randomized, double blind clinical trial aimed at repurposing an existing drug, cabergoline, as a safe, alternative angiogenesis inhibitor for adolescents and young women with endometriosis. This trial pro... Read More
Gender:
FEMALE
Ages:
Between 15 years and 40 years
Trial Updated:
03/19/2025
Locations: Standford University, Palo Alto, California +5 locations
Conditions: Endometriosis
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Evaluating the Impact of a Novel Cannabinoid Product for Endometriosis
NCT06477406
Recruiting
Despite the proliferation of cannabis and cannabinoid products in recent years, little research has been done to determine the impact of these products on womens health conditions, including endometriosis. This study is designed to assess the impact of a custom-formulated, hemp-derived, full-spectrum, high-CBD product vs. placebo on clinical symptoms and biomarkers over the course of 12 weeks of treatment in patients with endometriosis. This project will provide information that does not current... Read More
Gender:
FEMALE
Ages:
21 years and above
Trial Updated:
03/14/2025
Locations: McLean Hospital, Belmont, Massachusetts
Conditions: Endometriosis
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Pre-IVF Treatment with a GnRH Antagonist in Women with Endometriosis_temp
NCT06375811
Recruiting
A Phase 3 clinical trial of oral GnRH antagonist pre-treatment for women with endometriosis who are undergoing IVF, with a primary outcome of live birth rate. The investigators' central hypothesis is that in infertile woman with endometriosis undergoing in vitro fertilization-embryo transfer (IVF-ET), live birth rates will improve in those pretreated with GnRH antagonist compared to those not pretreated with GnRH antagonist.
Gender:
FEMALE
Ages:
Between 18 years and 40 years
Trial Updated:
03/06/2025
Locations: University of Colorado Department of Obstetrics & Gynecology, Aurora, Colorado +4 locations
Conditions: Infertility, Endometriosis
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