Improving Health Outcomes With Resource Facilitation
Recruiting
The purpose of this research is to test a service the investigators of the study believe may increase quality of life after brain injury and reduce the level of disability that might be associated with that injury. This intervention is called "Resource Facilitation" and involves working one on one with a brain injury specialist. This specialist is called a "Resource Facilitator" and will work with participants to help set and achieve their own goals along with a team of professionals that speci... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/12/2021
Locations: Rehabilitation Hospital of Indiana, Indianapolis, Indiana
Conditions: Traumatic Brain Injury, Rehabilitation, Intervention
Re-entry Continuum for Brain Injury
Recruiting
The overall research objectives of the proposed project are to decrease the rate of recidivism, defined as returning to incarceration within three years of release, as well as reduce the number of violent offenses, through the successful implementation of a continuum of services that addresses the unique needs of the TBI population. RHI, in partnership with PCF and IU, will work together to accomplish these goals. To meet study objectives, this randomized controlled trial (RCT) will enroll 102 i... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
04/05/2021
Locations: Putnamville Correctional Facility, Greencastle, Indiana
Conditions: Traumatic Brain Injury, Recidivism
Facilitators and Barriers to Cancer Screening: Stakeholder Perspectives on Implementation
Recruiting
The rate of screening for colorectal cancer (CRC) in the U.S. remains low (under 65%), meaning that thousands of people die of colorectal cancer unnecessarily. Colorectal cancer screening tests range from more invasive and very sensitive for polyps and cancer (colonoscopy) to less invasive and less sensitive (e.g., fecal immunochemical testing (FIT)). Screening rates go up when patients consider all these tests, not just colonoscopy. Informing patients about their options for CRC screening could... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/03/2021
Locations: Indiana University, Indianapolis, Indiana
Conditions: Colorectal Cancer Screening
An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Brownsburg, Indiana
Conditions: Ulcerative Colitis
ThRombosis ExclUsion STudy
Recruiting
The purpose of this study is to demonstrate the ability of new D-Dimer assay combined with a clinical pretest probability (PTP) to safely exclude pulmonary embolism (PE) or Deep Venous Thrombosis (DVT) in a 3 month follow-up.
Gender:
All
Ages:
80 years and below
Trial Updated:
01/04/2021
Locations: Indiana University Health, Indianapolis, Indiana
Conditions: Deep Venous Thromboses, Pulmonary Embolism, Venous Thromboembolism
ICNBs for Post-op Pain in Breast Surgery
Recruiting
The authors will conduct this study to analyze the effectiveness of peri-operative intercostal nerve blocks (ICNBs) in reducing acute postoperative pain after reconstructive breast surgery and mammoplasty and how it affects the length of hospital stay.
Gender:
Female
Ages:
Between 20 years and 70 years
Trial Updated:
12/07/2020
Locations: Ambulatory Surgery Center, Kleinert Kutz Hand Care Center, New Albany, Indiana
Conditions: Pain, Postoperative, Length of Stay
Evaluation of SUMMIT BRUSH in Treatment of Blepharitis
Recruiting
Dry Eye Disease (DED) is a multifactorial disease that affects ~15-30 million people in the USA alone. It creates an enormous societal and economic burden, decreases productivity in the workplace, and affects the quality of lives of the people affected by this disease. DED is primarily caused by blepharitis, a chronic inflammation of the eyelid margins. If left untreated, blepharitis results in the obstruction and loss of the glands responsible for tear film production. The standard of care is t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/24/2020
Locations: Michiana Eye Center, Mishawaka, Indiana
Conditions: Blepharitis
Study to Evaluate the Safety & Tolerability of MRT5005 Administered by Nebulization in Adults With Cystic Fibrosis
Recruiting
This Phase 1/2, first-in-human study will evaluate the safety and tolerability of single and multiple escalating doses of MRT5005 administered by nebulization to the respiratory tract of adult subjects with CF.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/12/2020
Locations: University of Indiana, Indianapolis, Indiana
Conditions: Cystic Fibrosis
MCJR Joint Replacement Clinical Outcomes Database
Recruiting
The purpose of this research study is to develop a database of information regarding the diagnosis, treatment, and outcome of participants who have had a joint replacement. The more information gathered, the better the investigators will be able to treat future patients who need a joint replacement. For example the investigators learn what works well to help design implants and treatment protocols for the future. The investigators publish manuscripts and present research findings around the worl... Read More
Gender:
All
Ages:
All
Trial Updated:
08/31/2020
Locations: Midwest Center for Joint Replacement, Indianapolis, Indiana
Conditions: Joint Replacement
Esophageal Impedance and Manometry Measurements and Dysphagia Symptom Scoring
Recruiting
Comparison of manometry measurements and EndoFlip Balloon measurements in patients with dysphagia and a known esophageal diagnosis
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
08/06/2020
Locations: Indiana University, Indianapolis, Indiana
Conditions: Dysphagia, Esophageal
Bioavailability of Single-dose Magnesium Salts
Recruiting
Magnesium plays a role in an array of critical body functions, controls normal adenosine triphosphate function, the metabolism of glucose, and cardiac muscle function, as well as the maintenance of cell membrane function. Low magnesium intakes and blood levels have been associated with a number of chronic diseases including hypertension, type 2 diabetes, metabolic syndrome, vascular disease, osteoporosis, and colon cancer. Magnesium deficiency is common. In the U.S. population, nearly 4% of men... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
06/23/2020
Locations: Indiana University, Bloomington, Indiana
Conditions: Bioavailability
Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated AML
Recruiting
A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treat... Read More
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
05/21/2020
Locations: Indiana University, Indianapolis, Indiana
Conditions: Newly Diagnosed FLT3 Mutated AML