Michigan is currently home to 2195 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Ann Arbor, Detroit, Grand Rapids and Kalamazoo. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study to Evaluate Safety and Tolerability of BPT567 in Patients With Advanced Solid Tumors
Recruiting
This is a first-in-human Phase Ia/Ib, open-label, multicenter, dose escalation and dose expansion study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and maximum tolerated dose (MTD) or maximum adminstered dose (MAD) of BPT567 in patients with advanced solid tumors, and establish the recommended dose for expansion cohorts.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: Start Midwest, Grand Rapids, Michigan
Conditions: Advanced Solid Tumors
A Clinical Trial to Assess COM503 in Participants with Advanced Solid Malignancies
Recruiting
The overall goal of this first-in-human (FIH) clinical trial is to learn about the safety and dosing of COM503 when given alone or in combination with zimberelimab in participants with advanced solid tumors. The primary objectives of this study are: * To assess the safety and tolerability of COM503 as monotherapy and COM503 in combination with zimberelimab in participants with advanced solid tumors. * To identify the maximum tolerated dose (MTD) / maximum administered dose (MAD) and/or the rec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: START Midwest, Grand Rapids, Michigan
Conditions: Neoplasm, Cancer, Malignant Tumors
Multimodal Investigation of Neural Plasticity
Recruiting
This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).
Gender:
ALL
Ages:
60 years and above
Trial Updated:
01/13/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Mild Cognitive Impairment
Pembrolizumab and Mogamulizumab in Advanced-stage, Relapsed/Refractory Cutaneous T-cell Lymphomas
Recruiting
This is an open-label, single-arm, multicenter, phase II study combining pembrolizumab and mogamulizumab in patients with advanced-stage, relapsed or refractory CTCL Each cycle will equal 6 weeks. Pembrolizumab will be administered on Day 1 of each cycle. Mogamulizumab will be administered on Day 1, 8, 15, and 22 of Cycle 1. For Cycle 2 and subsequent cycles, mogamulizumab will be administered on Day 1, 15 and 29 of each cycle. Subjects will undergo a response assessment prior to Cycle 3 and eve... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Conditions: Cutaneous T Cell Lymphoma, Fungoides Mycosis Sezary Syndrome
Youth Empowerment Solutions: Inclusion, Diversity, Equity, Appreciation and Solidarity
Recruiting
The purpose of this study is to evaluate the efficacy of YES-IDEAS (Youth Empowerment Solutions - Inclusion, Diversity, Equity, Appreciation, and Solidarity) compared to regular after school programming in increasing youth empowerment, promoting anti-racist behaviors, and decreasing youth violence. Through the evidence-based YES (Youth Empowerment Solutions) program, youth design and implement projects to help improve their communities. In the current study, investigators adapted the existing Y... Read More
Gender:
ALL
Ages:
Between 10 years and 15 years
Trial Updated:
01/13/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Violence Prevention
NBTXR3 Activated by Radiotherapy for Patients with Advanced Cancers Treated with an Anti-PD-1 Therapy
Recruiting
The 1100 study is an open-label, Phase I, dose escalation and expansion prospective clinical study to assess the safety of intratumoral injection of NBTXR3 activated by radiotherapy in combination with anti-PD-1 therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: Karmanos Cancer Institute, Detroit, Michigan
Conditions: Radiotherapy, Immunotherapy, Microsatellite Instability-High Solid Malignant Tumour, Squamous Cell Carcinoma of Head and Neck, Metastasis From Malignant Tumor of Cervix, Metastasis From Malignant Melanoma of Skin (Disorder), Metastasis From Malignant Tumor of Bladder (Disorder), Metastasis From Malignant Tumor of Liver, Metastatic Renal Cell Carcinoma, Metastatic Triple-Negative Breast Carcinoma, Metastatic NSCLC
Adversity, Brain and Opioid Use Study
Recruiting
The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and h... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
01/09/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Opioid Use Disorder, Healthy
BEACON: A Study Evaluating the Safety and Efficacy of BEAM-101 in Patients With Severe Sickle Cell Disease
Recruiting
This is an open-label, single-arm, multicenter, Phase 1/2 study evaluating the safety and efficacy of the administration of autologous base edited CD34+ HSPCs (BEAM-101) in patients with severe SCD
Gender:
ALL
Ages:
Between 18 years and 35 years
Trial Updated:
01/09/2025
Locations: Henry Ford Cancer Center, Detroit, Michigan
Conditions: Sickle Cell Disease
Family Health Histories: Creating a Culturally Tailored Tool to Reduce Health Disparities in the Black Community
Recruiting
The understanding, utilization and uptake of Family Health History is essential to the prevention of health disparities in the African American community. Creating a culturally tailored Family Health History tool, co-developed by members of the African American community will inform, educate and empower African Americans about health issues related to their family genealogy. Applying the knowledge gained via Family Health Histories to increase preventative behaviors including screenings thus lin... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/09/2025
Locations: Michigan State University, Flint, Michigan
Conditions: Hereditary Diseases
Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment
Recruiting
Clinical study to investigate the efficacy and safety of savolitinib in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on treatment with Osimertinib.
Gender:
ALL
Ages:
Between 18 years and 130 years
Trial Updated:
01/09/2025
Locations: Research Site, Detroit, Michigan
Conditions: Carcinoma, Non-Small-Cell Lung
Study of INBRX-109 in Conventional Chondrosarcoma
Recruiting
Randomized, blinded, placebo-controlled, Phase 2 study of INBRX-109 in unresectable or metastatic conventional chondrosarcoma patients.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/09/2025
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Conventional Chondrosarcoma
FUVID Study: Functional Characterization of Children With Chronic Venous Thromboembolic Disease
Recruiting
This is a multi-center prospective cohort study of patients with first-episode deep venous thrombosis and pulmonary embolism.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
01/09/2025
Locations: Central Michigan University, Mount Pleasant, Michigan
Conditions: Deep Venous Thrombosis, Pulmonary Embolism