Michigan is currently home to 2178 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Ann Arbor, Detroit, Grand Rapids and Kalamazoo. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Hyperbaric Oxygen Brain Injury Treatment Trial
Recruiting
The purpose of this innovative adaptive phase II trial design is to determine the optimal combination of hyperbaric oxygen treatment parameters that is most likely to demonstrate improvement in the outcome of severe TBI patients in a subsequent phase III trial.
Gender:
ALL
Ages:
Between 16 years and 65 years
Trial Updated:
02/06/2024
Locations: Detroit Receiving Hospital, Detroit, Michigan
Conditions: Traumatic Brain Injury
MACE CDS Software Master Enrollment Protocol
Recruiting
This protocol will collect real world EHR data to support the product development life cycle activities associated with developing the Major Adverse Cardiac Events (MACE) Clinical Decision Support (CDS) software. The data will also be utilized in subsequent clinical validation to support an FDA application and/or applications to other regulatory agencies as needed.
Gender:
ALL
Ages:
23 years and above
Trial Updated:
02/05/2024
Locations: Henry Ford Health System, Detroit, Michigan
Conditions: Cardiac Events
ETNA-MS Device Validation Study
Recruiting
The overarching goal of this research protocol is to validate the effectiveness of Innodem's ETNA-MS device in informing clinicians on the disability status of Multiple Sclerosis (MS) patients. Effectiveness of the device will be assessed by the level of agreement between the EDSS estimated by the device and the actual scores measured by the neurologist in-person assessments.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/05/2024
Locations: Michigan Institute for Neurological Disorders, Farmington Hills, Michigan
Conditions: Multiple Sclerosis
Safety, Tolerability and Pharmacokinetics of a Monoclonal Antibody Specific to B-and T-Lymphocyte Attenuator (BTLA) as Monotherapy and in Combination With an Anti-PD1 Monoclonal Antibody for Injection in Subjects With Advanced Malignancies
Recruiting
The primary objective is to assess the safety and tolerability of TAB004 as monotherapy and in combination with toripalimab in subjects with selected advanced solid malignancies, including lymphoma, and to evaluate the recommended Phase 2 dose. The secondary objectives are to: 1) describe the pharmacokinetic (PK) profile of TAB004 monotherapy and in combination with toripalimab and to describe the PK profile of toripalimab when administered with TAB004, 2) evaluate antitumor activity of TAB004... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/01/2024
Locations: Karmanos Cancer Institute, Detroit, Michigan
Conditions: Advanced Unresectable Solid Tumor, Metastatic Solid Tumor
Use of Stratafix Symmetric™ to Prevent Incisional Hernia in Gastrointestinal and Abdominal Surgery
Recruiting
Comparing the use of Stratafix Symmetric™ sutures to standard laparotomy closure sutures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/31/2024
Locations: West Michigan Cancer Center, Kalamazoo, Michigan
Conditions: C.Surgical Procedure; Disruption of Wound, Suture
Evaluation of Dupilumab in Patients With Atopic Keratoconjunctivitis (AKC)
Recruiting
This is a multi-center, double-masked, randomized, placebo-controlled, parallel-group, efficacy, safety, and tolerability study evaluating the efficacy of Dupilumab in the treatment of signs and symptoms of atopic keratoconjunctivitis (AKC).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: University of Michigan- Kellogg Eye Center, Ann Arbor, Michigan
Conditions: Atopic Keratoconjunctivitis
Evaluation of Stool Based Markers for the Early Detection of Colorectal Cancers and Adenomas
Recruiting
Colon cancer is the second most common cancer in men and women. It is a disease that can be prevented if it is found early. Colonoscopy is still the best screening tool for colon cancer and the polyps that turn into colon cancer. However, due to a variety of factors, including affordability, time, and age, not all patients are able to be screened. Researchers are working on other options for early detection that are as accurate as colonoscopy. The purpose of this study if to determine if stool... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/29/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Colonic Neoplasms
Watchful Waiting for Complete Responders to Therapy in Rectal Cancer
Recruiting
The purpose of this project is to determine if in a selected group of patients, at higher risk of wound dehiscence and other complications, treatment by local excision and management by a "watchful waiting" or an initial "non-operative management" approach, with an offer of radical resection only to those patients whose tumors demonstrate "regrowth" will maintain acceptable local control and overall survival rate for the whole cohort.
Gender:
ALL
Ages:
Between 18 years and 95 years
Trial Updated:
01/26/2024
Locations: Ascension St. John Hospital, Detroit, Michigan
Conditions: Rectal Cancer
Validation of Early Prognostic Data for Recovery Outcome After Stroke for Future, Higher Yield Trials
Recruiting
VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, transmagnetic stimulation (TMS), and MRI measures in the acute stroke time window.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Stroke, Stroke, Acute, Stroke, Ischemic, Stroke Hemorrhagic
A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( NATiV3 )
Recruiting
This Phase 3 study is conducted to evaluate lanifibranor in adults with NASH and liver fibrosis histological stage F2 or F3
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/24/2024
Locations: Clinical Research Institute of Michigan, Chesterfield, Michigan
Conditions: NASH - Nonalcoholic Steatohepatitis
Study of Eblasakimab in Male or Female Moderate-to-Severe Atopic Dermatitis Patients Previously Treated With Dupilumab
Recruiting
Multicenter, randomized, double-blind, placebo-controlled, parallel arm clinical study designed to evaluate the efficacy and safety of eblasakimab in participants with moderate-to-severe atopic dermatitis (AD) previously treated with dupilumab.The study consists of a 16-week treatment period and an 8-week follow-up period up to Week 24. Eligible participants will be randomized into one of the 2 treatment arms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/17/2024
Locations: ASLAN Investigative Site, Auburn Hills, Michigan
Conditions: Atopic Dermatitis
Diagnostic Performance of Small RNA Blood Test in Patients Undergoing Follow-up Imaging After Positive Low Dose CT Screening for Cancer of the Lung
Recruiting
2,000 individuals, aged 50-80 who have received a lung-RADS category 3 or 4 result on a LDCT screening study and who are scheduled for follow-up diagnostic imaging study, biopsy, clinical consultation or surgical appointment at one of the participating hospitals.
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
01/12/2024
Locations: Henry Ford Health, Detroit, Michigan
Conditions: Lung Cancer