Michigan is currently home to 2254 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Ann Arbor, Detroit, Grand Rapids and Kalamazoo. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Regenerative Peripheral Nerve Interfaces to Treat Painful Digit and Hand Neuromas After Amputation
Recruiting
This study is being done to demonstrate the effectiveness of Regenerative Peripheral Nerve Interfaces (RPNI) surgery in treating symptomatic neuromas of the hand and digits following amputation compared to standard of care using a Prospective, Observational Trial
Gender:
All
Ages:
18 years and above
Trial Updated:
04/11/2023
Locations: University of Michigan Plastic Surgery, Ann Arbor, Michigan
Conditions: Neuroma
Pharmacokinetics, Safety and Efficacy of Nemolizumab in Participants With Moderate-to-Severe Atopic Dermatitis
Recruiting
The purpose of this study is to assess the pharmacokinetics (PK), efficacy, and safety of nemolizumab in pediatric participants with moderate-to-severe atopic dermatitis (AD).
Gender:
All
Ages:
Between 2 years and 12 years
Trial Updated:
04/05/2023
Locations: Galderma Investigational Site #8155, Troy, Michigan
Conditions: Moderate-to-Severe Atopic Dermatitis
The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis Study
Recruiting
A prospective, non blinded, single arm, multicenter study designed to assess the safety and effectiveness of the bioprosthetic, VenoValve, which is surgically implanted into the deep venous system for treatment of patients with deep venous valvular insufficiency ( C4b-C6 patients).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2023
Locations: Henry Ford Health System, Detroit, Michigan
Conditions: Deep Venous Insufficiency (Diagnosis)
Blood Biomarker Study to Diagnose Adolescent Sport Concussion
Recruiting
Concussions are one of the most complex conditions to manage in sport medicine due to the individualized clinical presentation, caused by a complex neurometabolic cascade, and the lack of a diagnostic standard. There is currently no objective measurement for concussion and the reliance on subjective reporting and clinical judgement is imperfect. In previous clinical studies the investigators determined cutoff values of plasma phosphatidylcholines that provided strong indication that a concussio... Read More
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
03/31/2023
Locations: Legacy Center Sports Complex, Brighton, Michigan
Conditions: Brain Concussion
C-myc Biomarker Study for Diabetic Foot Ulcers
Recruiting
This is a multi-center observational cohort study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict complete wound healing. Eligible and consented participants will begin standard of care treatment after collection of tissue specimens from the wound's edge. An additional tissue specimen is collected at 4 weeks if clinically indicated. Tissues will be tested for c-myc and phosphorylated glucocorticoid receptor (p-GR) levels using va... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/29/2023
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Diabetes, Diabetic Foot, Diabetic Foot Ulcer, Diabetic Wound
Assessment of the Utility of the Pantheris Small Vessel (SV) System
Recruiting
A single-arm study to assess the utility of the Pantheris SV catheter in addressing peripheral artery disease in arteries located below the knee. Data will be collected on the percent stenosis pre- and post-atherectomy and then symptoms and adverse events noted at 30 days, 6 months, and 1 year after the procedure.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: Advanced Cardiac and Vascular Centers, Grand Rapids, Michigan
Conditions: Peripheral Arterial Disease
BP1001-A in Patients With Advanced or Recurrent Solid Tumors
Recruiting
This is a phase I, open-label, study of BP1001-A in participants with advanced or recurrent solid tumors. The dose escalation phase will determine the safety and the maximum tolerated dose (MTD) or maximum administered dose (MAD) of BP1001-A as a single agent. After the MTD or MAD of BP1001-A is established, the dose expansion phase will commence and determine the safety, toxicity and response of BP1001-A in combination with paclitaxel.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: Karmanos Cancer Institute, Detroit, Michigan
Conditions: Solid Tumor, Adult, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Endometrial Cancer, Peritoneal Cancer, Solid Tumor
Screening and Intervention for Glaucoma and Eye Health Through Telemedicine
Recruiting
This is a multiple site, randomized study that will assess the effects of personalized eHealth education and motivational-interviewing-based counseling on patient adherence to physician follow-up appointments.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
03/24/2023
Locations: Hamilton Community Health Clinic, Flint, Michigan
Conditions: Glaucoma
Outpatient Transcervical Balloon For Induction of Labor
Recruiting
The goal of this randomized control trial is to compare outpatient transcervical foley balloon to inpatient vaginal misoprostol in pregnant women for cervical ripening. The main questions it aims to answer are: Does outpatient transcervical foley balloon decreased the time from admission to delivery compared to inpatient vaginal misoprostol Does outpatient transcervical foley balloon will increase risk of c-section during induction of labor compared to inpatient vaginal misoprostol Participant... Read More
Gender:
Female
Ages:
Between 18 years and 65 years
Trial Updated:
03/22/2023
Locations: Hurley Medical Center, Flint, Michigan
Conditions: Induced Vaginal Delivery, Induced; Birth
Role of Sleep Reactivity in Shift Work Disorder
Recruiting
The purpose of this project is to test sleep reactivity as an independent cause of Shift Work Disorder (SWD). The primary hypothesis is that those with high sleep reactivity will show persistent SWD symptoms after experimental reduction of circadian misalignment, which will then be mitigated with CBT.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/16/2023
Locations: Henry Ford Columbus Medical Center, Novi, Michigan
Conditions: Shift-work Disorder
A Study Of The Selective PKC-β Inhibitor MS- 553
Recruiting
A Phase I/II Dose-Escalation and Expansion Study Of The Selective PKC-Β Inhibitor MS-553 In Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Gender:
All
Ages:
18 years and above
Trial Updated:
03/13/2023
Locations: University Of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Aggressive Lymphoma
Post Approval Study for Treatment of Drug-resistant Adult and Pediatric Primary FSGS Using the LIPOSORBER® LA-15 System
Recruiting
This multicenter, prospective, single-arm clinical study will evaluate the probable benefit and safety of the LIPOSORBER® LA-15 System for the treatment of adult patients with nephrotic syndrome associated with primary focal segmental glomerulosclerosis, when the standard treatment options, including corticosteroid and/or calcineurin inhibitors treatments, have been unsuccessful or not well tolerated, and the patient has a GFR ≥ 45 ml/min/1.73m2, or the patient has post-renal transplant recurren... Read More
Gender:
All
Ages:
75 years and below
Trial Updated:
03/09/2023
Locations: Helen DeVos Children's Hospital, Grand Rapids, Michigan
Conditions: Focal Segmental Glomerulosclerosis