Michigan is currently home to 2250 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Ann Arbor, Detroit, Grand Rapids and Kalamazoo. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Regenerative Peripheral Nerve Interfaces to Treat Painful Digit and Hand Neuromas After Amputation
Recruiting
This study is being done to demonstrate the effectiveness of Regenerative Peripheral Nerve Interfaces (RPNI) surgery in treating symptomatic neuromas of the hand and digits following amputation compared to standard of care using a Prospective, Observational Trial
Gender:
All
Ages:
18 years and above
Trial Updated:
04/11/2023
Locations: University of Michigan Plastic Surgery, Ann Arbor, Michigan
Conditions: Neuroma
ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma
Recruiting
This is a multicenter open-label, randomized, non-comparative, parallel cohort pivotal study of treatment with envafolimab (cohort A and C) or envafolimab combined with ipilimumab (cohort B and D) in patients with locally advanced, unresectable or metastatic undifferentiated pleomorphic sarcoma (UPS)/myxofibrosarcoma (MFS) who have progressed on one or two lines of chemotherapy.
Gender:
All
Ages:
12 years and above
Trial Updated:
04/10/2023
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma
Metastatic Leiomyosarcoma Biomarker Protocol
Recruiting
Leiomyosarcoma (LMS) is one of the most prevalent soft tissue sarcomas (STS) and can occur in various sites including soft tissue, uterus and retroperitoneal large vessels. Metastatic disease occurs in approximately 50% of patients diagnosed with leiomyosarcoma and prognosis is poor in setting of metastatic disease. A minority of patients benefit from treatment with chemotherapy and early biomarkers of benefit from treatment are lacking. A biomarker of tumor response and patient survival benefit... Read More
Gender:
All
Ages:
All
Trial Updated:
04/05/2023
Locations: University of Michigan Cancer Center, Ann Arbor, Michigan
Conditions: Leiomyosarcoma
Pharmacokinetics, Safety and Efficacy of Nemolizumab in Participants With Moderate-to-Severe Atopic Dermatitis
Recruiting
The purpose of this study is to assess the pharmacokinetics (PK), efficacy, and safety of nemolizumab in pediatric participants with moderate-to-severe atopic dermatitis (AD).
Gender:
All
Ages:
Between 2 years and 12 years
Trial Updated:
04/05/2023
Locations: Galderma Investigational Site #8155, Troy, Michigan
Conditions: Moderate-to-Severe Atopic Dermatitis
Assessing Effects of Heparin Priming and Pass Number on Tissue Quality of Fine Needle Biopsies
Recruiting
This is a randomized study that will enroll patients scheduled for an endoscopic ultrasound biopsy of a pancreas lesion to be in the heparin or saline group during the procedure. The purpose of this study is to examine the effect of blood contamination, heparin priming of the fine needle biopsies, and pass number on tumor tissue quality in fine needle biopsies. The hypothesis for this study is that fine needle biopsy tissue quality of pancreatic masses decreases with increasing pass number due... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/05/2023
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Pancreas, Mass Lesion
The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis Study
Recruiting
A prospective, non blinded, single arm, multicenter study designed to assess the safety and effectiveness of the bioprosthetic, VenoValve, which is surgically implanted into the deep venous system for treatment of patients with deep venous valvular insufficiency ( C4b-C6 patients).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/04/2023
Locations: Henry Ford Health System, Detroit, Michigan
Conditions: Deep Venous Insufficiency (Diagnosis)
Blood Biomarker Study to Diagnose Adolescent Sport Concussion
Recruiting
Concussions are one of the most complex conditions to manage in sport medicine due to the individualized clinical presentation, caused by a complex neurometabolic cascade, and the lack of a diagnostic standard. There is currently no objective measurement for concussion and the reliance on subjective reporting and clinical judgement is imperfect. In previous clinical studies the investigators determined cutoff values of plasma phosphatidylcholines that provided strong indication that a concussio... Read More
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
03/31/2023
Locations: Legacy Center Sports Complex, Brighton, Michigan
Conditions: Brain Concussion
Warfarin Patient Self-management Implementation in the US Healthcare System
Recruiting
In the US, patients receiving warfarin therapy are rarely allowed to engage in patient self-management (PSM) which is less burdensome, less expensive, and safer than standard clinic-directed warfarin management. The long-term objective of our application is to improve the safety of ambulatory warfarin therapy through increasing the implementation of PSM.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/29/2023
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Atrial Fibrillation, Venous Thromboembolism, Heart Valve Diseases
C-myc Biomarker Study for Diabetic Foot Ulcers
Recruiting
This is a multi-center observational cohort study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict complete wound healing. Eligible and consented participants will begin standard of care treatment after collection of tissue specimens from the wound's edge. An additional tissue specimen is collected at 4 weeks if clinically indicated. Tissues will be tested for c-myc and phosphorylated glucocorticoid receptor (p-GR) levels using va... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/29/2023
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Diabetes, Diabetic Foot, Diabetic Foot Ulcer, Diabetic Wound
Assessment of the Utility of the Pantheris Small Vessel (SV) System
Recruiting
A single-arm study to assess the utility of the Pantheris SV catheter in addressing peripheral artery disease in arteries located below the knee. Data will be collected on the percent stenosis pre- and post-atherectomy and then symptoms and adverse events noted at 30 days, 6 months, and 1 year after the procedure.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: Advanced Cardiac and Vascular Centers, Grand Rapids, Michigan
Conditions: Peripheral Arterial Disease
BP1001-A in Patients With Advanced or Recurrent Solid Tumors
Recruiting
This is a phase I, open-label, study of BP1001-A in participants with advanced or recurrent solid tumors. The dose escalation phase will determine the safety and the maximum tolerated dose (MTD) or maximum administered dose (MAD) of BP1001-A as a single agent. After the MTD or MAD of BP1001-A is established, the dose expansion phase will commence and determine the safety, toxicity and response of BP1001-A in combination with paclitaxel.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/27/2023
Locations: Karmanos Cancer Institute, Detroit, Michigan
Conditions: Solid Tumor, Adult, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Endometrial Cancer, Peritoneal Cancer, Solid Tumor
Screening and Intervention for Glaucoma and Eye Health Through Telemedicine
Recruiting
This is a multiple site, randomized study that will assess the effects of personalized eHealth education and motivational-interviewing-based counseling on patient adherence to physician follow-up appointments.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
03/24/2023
Locations: Hamilton Community Health Clinic, Flint, Michigan
Conditions: Glaucoma