Noninvasive Evaluation for Carotid Artery Stenosis: The Carotid Stenotic Scan
Recruiting
The purpose of this study is to determine the accuracy of a new non-invasive device, the Carotid Stenotic Scan (CSS), to check for stenosis of the internal carotid artery (ICA) as compared to a carotid duplex ultrasound study.
Gender:
All
Ages:
65 years and above
Trial Updated:
08/14/2019
Locations: Michigan Vascular Center, Flint, Michigan
Conditions: Carotid Stenosis
A Comparison of Intra-operative Radiotherapy Boost With External Beam Radiotherapy Boost in Early Breast Cancer.
Recruiting
TARGIT-Boost is an international randomised clinical trial designed to test the hypothesis that the tumour bed boost delivered as a single dose of targeted intraoperative radiotherapy (TARGIT-B) is superior to the conventional course of external beam radiotherapy boost (EBRT-Boost), especially in women with high risk of local recurrence. It is a pragmatic trial in which each participating centre can use the local predefined inclusion/exclusion criteria for entry into the trial. Only centres with... Read More
Gender:
Female
Ages:
All
Trial Updated:
07/10/2019
Locations: Beaumont Health - Royal Oak, Detroit, Michigan
Conditions: Early Breast Cancer
Prenatal Computer-Aided Genetics Education Module
Recruiting
A standard part of obstetrical care is offering prenatal genetic screening. Numerous professional guidelines have emphasized the importance of pretest counseling for prenatal genetic screenings. Informed consent includes the optional nature of the test, information on the conditions being screened, possible test results, implication of each result, and the type of test offered (screening or diagnostic). This responsibility falls on the physician in a busy clinic. Technology may be able to addres... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
04/30/2019
Locations: Hutzel Women's Hospital, Detroit, Michigan
Conditions: Autosomal Recessive Disorder, Aneuploidy
Cerebrotendinous Xanthomatosis (CTX) Prevalence Study
Recruiting
This is an observational, multicenter study to determine the prevalence of Cerebrotendinous Xanthomatosis (CTX) in patient populations diagnosed with early-onset idiopathic bilateral cataracts. Patients who are potentially eligible for study participation will be identified through a chart review of patients who were seen at each study site prior to that site's initiation, or by entering care at the site while the site is participating in the trial.
Gender:
All
Ages:
Between 2 years and 21 years
Trial Updated:
11/07/2018
Locations: University of Michigan Kellogg Eye Center, Ann Arbor, Michigan
Conditions: Cerebrotendinous Xanthomatosis (CTX)
Remote Ischemic Conditioning Using the autoRIC
Recruiting
The purpose of the study is to evaluate the hypothesis that patients receiving remote ischemic conditioning using the autoRIC device show statistically significant reduction in the prevalence of ischemia-reperfusion injury to the myocardium as compared to patients in the autoRIC Sham device arm (within 12-24 hours post non-emergent PCI with stent implantation).
Gender:
All
Ages:
18 years and above
Trial Updated:
08/28/2018
Locations: Henry Ford Hospital, Detroit, Michigan
Conditions: Ischemia-Reperfusion Injury
Prospective Outcomes Study: Vectra® DA Guided Care Compared to Usual Care
Recruiting
In this 12-month multi-center prospective, site-randomized, two-arm trial, approximately 318 biologic-naïve subjects with RA who are candidates for treatment intensification due to inadequate response to MTX monotherapy will be enrolled at up to 60 study sites.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/27/2018
Locations: University of Michigan, Ann Arbor, Michigan
Conditions: Arthritis, Rheumatoid
TARGET Intracranial Aneurysm Coiling Registry
Recruiting
The purpose of this prospective registry is to collect real world, post-marketing data on the use of Stryker Target® 360,Target® 2D, and 2nd generation Target® Nano coils for the embolization of ruptured or unruptured intracranial saccular aneurysms. Up to 300 patients (150 in the TARGET 360°/Helical arm and 150 in the New NANO arm) presenting with intracranial aneurysms suitable for coil embolization will be enrolled at up to 20 sites. A post hoc analysis comparing Target® 360° and Target® 2D c... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/20/2018
Locations: McLaren Health, Flint, Michigan
Conditions: Intracranial Aneurysms
Telescope Exchange Study
Recruiting
VisionCare's Implantable Miniature Telescope (IMT, intraocular telescope or telescope) is indicated for monocular implantation to improve vision in eyes of patients at least 65 years of age with severe to profound vision impairment caused by bilateral central scotomas associated with end-stage age-related macular degeneration (AMD). Patients with end-stage AMD who have undergone bilateral cataract removal and intraocular lens placement are currently contraindicated for telescope surgery. These... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
04/25/2018
Locations: University of Michigan, Kellogg Eye Center, Ann Arbor, Michigan
Conditions: Age-related Macular Degeneration
Cryoablation of Small Breast Tumors in Early Stage Breast Cancer
Recruiting
This study examines the use of cryoablation as an alternative to surgery in the treatment of early stage invasive breast cancer. The hypothesis is that cryoablation will complete ablation and destroy the tumor in a selected population of women who may otherwise be adequately treated with surgery.
Gender:
Female
Ages:
50 years and above
Trial Updated:
04/19/2018
Locations: Ascension Crittenton Hospital, Rochester, Michigan
Conditions: Breast Cancer
Efficacy of Adjuvant Mitotane Treatment (ADIUVO)
Recruiting
Study Rationale Adrenocortical carcinoma (ACC) is a very rare disease with a high risk of relapse after radical surgery. The efficacy of adjuvant mitotane treatment is suggested by a retrospective multicenter international study showing that postoperative mitotane treatment was associated with a significant reduction of the risk of relapse and death. However, these promising results need confirmation in a randomized prospective study. Caution should be adopted particularly in patients with low r... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/04/2017
Locations: Endocrine Oncology - University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan
Conditions: Adrenocortical Carcinoma
Efficacy of Implantable Defibrillator Therapy After a Myocardial Infarction
Recruiting
This study will assess whether an implantable defibrillator will increase the likelihood of survival in patients who have had a heart attack in the prior 5 years, have abnormal test results from a 24 hour heart monitor, and who have low normal heart function.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/07/2016
Locations: Washington University Medical School, Saint Louis, Michigan
Conditions: Myocardial Infarction, Sudden Death