Minnesota is currently home to 2107 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Modified VR-CAP and Acalabrutinib as First Line Therapy for the Treatment of Transplant-Eligible Patients With Mantle Cell Lymphoma
NCT04626791
Recruiting
This phase II trial investigates how well modified VR-CAP (bortezomib, rituximab, cyclophosphamide, doxorubicin hydrochloride, prednisone, and cytarabine hydrochloride) and acalabrutinib as first line therapy work in treating transplant-eligible patients with mantle cell lymphoma. Modified VR-CAP is a combination of drugs used as standard first line treatment for mantle cell lymphoma. Chemotherapy drugs, such as bortezomib, cyclophosphamide, doxorubicin hydrochloride, and cytarabine hydrochlorid... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/08/2024
Locations: Metropolitan-Mount Sinai Medical Center, Minneapolis, Minnesota
Conditions: Mantle Cell Lymphoma
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CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults
NCT06305910
Recruiting
This is a single center Phase I study of a new adjuvant CD200 activation receptor ligand, CD200AR-L, in combination with imiquimod and GBM6-AD vaccine to treat malignant glioma in children and young adults. The primary objective of this study is to determine the maximum tolerated dose (MTD) of CD200AR-L when given with a fixed dose of GBM6-AD vaccine, imiquimod, and a single dose of radiation for patients with recurrent High Grade Glioma (HGG) or following standard of care therapy radiation the... Read More
Gender:
ALL
Ages:
Between 2 years and 25 years
Trial Updated:
03/05/2024
Locations: Children's Minnesota, Minneapolis, Minnesota
Conditions: Diffuse Midline Glioma, H3 K27M-Mutant, Recurrent High Grade Glioma
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A Study of Vedolizumab in Children With Ulcerative Colitis (UC) or Crohn's Disease (CD)
NCT05442567
Recruiting
The study is an extension of two parent studies (MLN0002-3024 \[NCT04779307\] and MLN0002-3025 \[NCT04779320\]). Participants must have participated in one of the previous studies. The purpose of this study is to collect the long-term safety of vedolizumab in children with UC or CD.
Gender:
ALL
Ages:
2 years and above
Trial Updated:
03/05/2024
Locations: MNGI Digestive Health PA-Plymouth, Minneapolis, Minnesota
Conditions: Ulcerative Colitis, Crohn's Disease
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Cerebral Hemorrhage Risk in Hereditary Hemorrhagic Telangiectasia
NCT01158807
Recruiting
This study is one of the three projects of an NIH Rare Disease Clinical Research Consortium. A "consortium" is a group of centres sharing information and resources to perform research. The consortium research focuses on brain blood vessel malformations in three different rare diseases. The focus of this specific study is on Hemorrhagic Telangiectasia (HHT). HHT is a condition characterized by blood vessel malformations, called telangiectasia and arteriovenous malformations (AVMs), occurring in... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/04/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Hereditary Hemorrhagic Telangiectasia
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Efficacy and Safety of REC-2282 in Patients With Progressive Neurofibromatosis Type 2 (NF2) Mutated Meningiomas
NCT05130866
Recruiting
This is a two-staged, Phase 2/3, randomized, multi-center study to investigate the efficacy and safety of REC-2282 in patients with progressive NF2 mutated meningiomas.
Gender:
ALL
Ages:
12 years and above
Trial Updated:
02/29/2024
Locations: University of Minnesota / Masonic Cancer Center, Minneapolis, Minnesota
Conditions: Neurofibromatosis Type 2
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Chemotherapy Induced Peripheral Neuropathy Natural History Study (EPIPHANY)
NCT03997981
Recruiting
This is a prospective natural history study of CIPN in approximately 200 participants receiving taxanes (paclitaxel, docetaxel) for breast cancer, bortezomib for multiple myeloma, oxaliplatin-based regimens for colorectal cancer, or vincristine for lymphoma.. Demographic data, medical history, electronic PROs, ClinROs blood biomarkers including NF-L, PGx DNA analyses and Bedside-QST will be assessed at Baseline. The Observation Period will initiate with the first dose of chemotherapy and conclud... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/29/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Chemotherapy-induced Peripheral Neuropathy
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Augmenting Ankle Plantarflexor Function in Cerebral Palsy
NCT05154253
Recruiting
The first specific aim is to quantify improvement in ankle muscle function and functional mobility following targeted ankle resistance gait training in ambulatory children with cerebral palsy (CP). The primary hypothesis for the first aim is that targeted ankle resistance training will produce larger improvements in lower-extremity motor control, gait mechanics, and clinical measures of mobility assessed four- and twelve-weeks post intervention compared to standard physical therapy and standard... Read More
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
02/27/2024
Locations: Gillette Children's Specialty Healthcare, Minneapolis, Minnesota
Conditions: Cerebral Palsy
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Cortical Spreading Depolarization After Severe Traumatic Brain Injury
NCT03321370
Recruiting
Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring neurosurgical intervention.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/27/2024
Locations: Hennepn Healthcare, Minneapolis, Minnesota
Conditions: Traumatic Brain Injury
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Enroll -HD: A Prospective Registry Study in a Global Huntington's Disease Cohort
NCT01574053
Recruiting
Enroll-HD is a longitudinal, observational, multinational study that integrates two former Huntington's disease (HD) registries-REGISTRY in Europe, and COHORT in North America and Australasia-while also expanding to include sites in Latin America. More than 30,000 participants have now enrolled into the study. With annual assessments and no end date, Enroll-HD has built a large and rich database of longitudinal clinical data and biospecimens that form the basis for studies developing tools and b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/26/2024
Locations: Hennepin County Medical Center, Minneapolis, Minnesota
Conditions: Huntington's Disease
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Fetoscopic Endoluminal Tracheal Occlusion
NCT05771688
Recruiting
This is a single site pilot trial to study the feasibility of Fetoscopic Endoluminal Tracheal Occlusion (FETO) therapy in the most severe group of fetuses with congenital diaphragmatic hernia (CDH) at Midwest Fetal Care Center, a collaboration between Allina Health and Children's Minnesota. This procedure aims to increase fetal lung volume before birth and improve survival after birth. This study will enroll 10 pregnant people and their baby who meet study criteria.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: Midwest Fetal Care Center, Minneapolis, Minnesota
Conditions: Hernia, DIaphragmatic, Congenital
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Observational Registry to Assess the Durability of Effect of CXL in Patients With Corneal Ectasia After Refractive Surgery
NCT03319082
Recruiting
The objectives of this post market registry are to evaluate the safety and durability of treatment effect up to 3 years following cross-linking performed with Photrexa Viscous (riboflavin 5'- phosphate in 20% dextran ophthalmic solution), Photrexa (riboflavin 5'- phosphate ophthalmic solution), and the KXL System in patients with corneal ectasia following refractive surgery.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/22/2024
Locations: Chu Vision Institute, P.A., Bloomington, Minnesota
Conditions: Corneal Ectasia
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The Tether™ - Vertebral Body Tethering System Post Approval Study
NCT04505579
Recruiting
This study is an opportunity to provide continued reasonable assurance of the safety and probable benefit of The Tether HUD. The study will collect long term safety and efficacy information from patients who have had their idiopathic scoliosis treated via anterior vertebral body tethering (AVBT) with The Tether.
Gender:
ALL
Ages:
All
Trial Updated:
02/21/2024
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Scoliosis Idiopathic
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