Minnesota is currently home to 2094 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Minneapolis, Rochester, Saint Paul and Duluth. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations
NCT04042831
Recruiting
This phase II trial studies how well olaparib works in treating patients with biliary tract cancer that has spread to other places in the body (metastatic) and with aberrant DNA repair gene mutations. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/11/2023
Locations: Mayo Clinic in Rochester, Rochester, Minnesota
Conditions: Bile Duct Adenocarcinoma, Fanconi Anemia Complementation Group Gene Mutation, Metastatic Bile Duct Carcinoma, PTEN Gene Deletion
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Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients (FIBROSARC USA)
NCT03420014
Recruiting
The present study is an open-label, randomized, controlled, two-arm multi-center study of the efficacy of L19TNF treatment in combination with doxorubicin versus doxorubicin alone in metastatic leiomyosarcoma patients.
Gender:
ALL
Ages:
Between 16 years and 100 years
Trial Updated:
10/06/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Leiomyosarcoma
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Study to Evaluate R2R01 Plus Terlipressin Versus Terlipressin Alone in Patients With Hepatorenal Syndrome
NCT05875948
Recruiting
This study aims to evaluate the safety, tolerability and efficacy of R2R01 combined with terlipressin as compared to terlipressin alone in the treatment of patients with HRS-AKI
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/29/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Hepatorenal Syndrome, Acute Kidney Injury
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Longitudinal Study to Determine the Effectiveness of the Mobility Checkup for Older Adults
NCT05745402
Recruiting
The investigators are developing a new, preventative physical therapy model of care for older adults called Mobility Checkup (MC). Proposed as an annual visit, the MC includes measurement of physical performance and education regarding the importance of maintaining mobility for overall health. The purpose of this study is to determine the feasibility of and begin data collection for, a longitudinal study of the effectiveness of the Mobility Checkup with a small cohort. This activity will evaluat... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
09/25/2023
Locations: College of St. Scholastica-Health Science Center, Duluth, Minnesota
Conditions: Healthy Aging
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PV Loop and Pulmonary Hypertension
NCT05484596
Recruiting
The right ventricular (RV) systolic function is a key determinant of outcome in patients with pulmonary hypertension and elevated pulmonary vascular resistance. As the pulmonary artery pressure and vascular resistance increase (i.e. RV afterload) in these patients, so does the right ventricular contractility in an attempt to maintain cardiac output. This is response of a ventricle to its afterload is termed ventriculo-arterial (VA) coupling. However, there is a limit to this increase in contract... Read More
Gender:
ALL
Ages:
Between 1 year and 21 years
Trial Updated:
09/22/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Pulmonary Vascular Resistance Abnormality
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Ketogenic Diet Following Moderate to Severe Pediatric Traumatic Brain Injury
NCT04933448
Recruiting
The primary objective of this study is to evaluate the feasibility and safety of using the ketogenic diet (KD) in children who sustained moderate to severe traumatic brain injury (TBI). The secondary objective is a preliminary evaluation of the outcomes of children who have had the standard of care plus the KD, compared to those with standard of care alone. Outcome measures for the secondary objective will include: need for ventriculoperitoneal shunt, duration of unconsciousness, need for any ty... Read More
Gender:
ALL
Ages:
Between 2 years and 17 years
Trial Updated:
09/15/2023
Locations: Gillette Children's Specialty Healthcare, Minneapolis, Minnesota
Conditions: Traumatic Brain Injury
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Assessment of Allogeneic Hematopoietic Cell Transplantation in Medicare Beneficiaries With Multiple Myeloma
NCT03127761
Recruiting
Multiple myeloma (MM) is the second most common hematologic malignancy in adults. The current standard of care for MM patients fit to undergo high dose conditioning chemotherapy is an autologous HCT (autoHCT). Allogeneic HCT (alloHCT) is the only potentially curative therapy available to patients with MM. However, the significant morbidity and mortality of this procedure historically limited its application in older patients. Thus, although potentially curative, standard risk MM patients have e... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/29/2023
Locations: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
Conditions: Multiple Myeloma
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Prospective Assessment of Allogeneic Hematopoietic Cell Transplantation in Patients With Myelofibrosis
NCT02934477
Recruiting
This observational study will compare outcomes of a prospectively-enrolled cohort of Hematopoietic Stem Cell Transplant (HCT) recipients with outcomes of a cohort of age-matched historical non-HCT controls. Patients undergoing alloHCT will receive HCT in a US transplant center and be reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) using well-established CIBMTR report forms and data collection procedures as well as a study-specific supplemental form. Data on... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
08/29/2023
Locations: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota
Conditions: Myelofibrosis
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A Study of Voruciclib Alone or in Combination With Venetoclax in Subjects With B-Cell Malignancies or AML
NCT03547115
Recruiting
This is a Phase 1, open-label, dose escalation study to determine the safety and preliminary efficacy of voruciclib monotherapy in subjects with relapsed/refractory B cell malignancies or AML after failure of standard therapies or voruciclib in combination with venetoclax in subjects with relapsed or refractory AML
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/03/2023
Locations: Mayo Clinic, Rochester, Minnesota
Conditions: Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), Small Lymphocytic Lymphoma (SLL), Chronic Lymphocytic Leukemia (CLL), Diffuse Large B-cell Lymphoma (DLBCL), Acute Myeloid Leukemia (AML)
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Determining How Indoor Lighting Affects the Brain Health of Older Adults
NCT05978934
Recruiting
The goal of this randomized, cross-over, single-site trial followed by an exploratory third intervention is to understand how indoor lighting affects different measures of brain health in older adults living in independent living residences. This is a community based study occurring in a local senior living facility. The main question this study aims to answer is: - How does the quality of ambient indoor lighting an older adult is exposed to affect measures of brain health, such as sleep qualit... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
07/28/2023
Locations: The Waters on Mayowood, Rochester, Minnesota
Conditions: Sleep, Physical Activity, Cognitive Function, Social Isolation
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Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias
NCT01060371
Recruiting
Spinocerebellar ataxias (SCA) are genetic neurological diseases that cause imbalance, poor coordination, and speech difficulties. There are different kinds of SCA and this study will focus on types 1, 2,3, and 6 (SCA 1, SCA 2, SCA 3 , also known as Machado-Joseph disease and SCA 6). The diseases are rare, slowly progressive, cause increasingly severe neurological difficulties and are variable across and within genotypes. The purpose of this research study is to bring together a group of experts... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
05/30/2023
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3, Spinocerebellar Ataxia Type 6
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Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries
NCT04920474
Recruiting
The primary purpose of the Research Sample Repository is to make blood samples available for research studies related to histocompatibility and hematopoietic cell transplantation (HCT) or other cellular therapy. Representatives of participating centers and investigators or research groups may request access to research samples contained in the Research Sample Repository for the purpose of conducting research including: * investigating molecular explanations for histocompatibility or clinical o... Read More
Gender:
ALL
Ages:
All
Trial Updated:
05/01/2023
Locations: NMDP Biorepository, New Brighton, Minnesota
Conditions: Autologous Stem Cell Transplantation, Allogeneic Stem Cell Transplantation, Cellular Therapy, Marrow Toxic Injury
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