North Carolina is currently home to 2747 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Durham, Winston-Salem, Charlotte and Chapel Hill. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Remote Ischemic Conditioning, Bimanual Skill Learning, and Corticospinal Excitability
NCT05355883
Recruiting
Unilateral cerebral palsy (UCP) is a leading cause of childhood disability. An early brain injury impairs the upper extremity function, bimanual coordination, and impacts the child's independence. The existing therapeutic interventions have higher training doses and modest effect sizes. Thus, there is a critical need to find an effective priming agent to enhance bimanual skill learning in children with UCP. This study aims to determine the effects of a novel priming agent, remote ischemic condit... Read More
Gender:
All
Ages:
Between 6 years and 16 years
Trial Updated:
04/26/2022
Locations: Dept. of Physical Therapy, East Carolina University, Greenville, North Carolina
Conditions: Unilateral Cerebral Palsy, Hemiplegic Cerebral Palsy, Remote Ischemic Conditioning
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Effects of Graded Protein Intake on Body Composition in Older Adults
NCT04845282
Recruiting
This clinical trial is intended to evaluate the effects of protein intake graded to resistance training volume over a 10-week period on macroscopic skeletal muscle adaptations and body composition. Briefly, all participants will complete a progressive resistance training protocol for 10 weeks, with one group consuming a constant amount of total daily protein (RDA of 0.8g/kg/day) to serve as an active comparator. The alternative group will consume total daily protein and protein supplement in a g... Read More
Gender:
All
Ages:
Between 55 years and 110 years
Trial Updated:
04/26/2022
Locations: Wake Forest University Clinical Research Center, Winston-Salem, North Carolina
Conditions: Sarcopenia
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A Biospecimen Collection Study of Leukapheresis-Derived Circulating Tumor Cells, Immune Cells, and Progenitor Cells.
NCT00571389
Recruiting
Primary Objective: This is a study to investigate the feasibility of harvesting, expanding, and selecting T lymphocytes from cancer patients and healthy volunteers. The preliminary objective of this study is aimed at selecting PD-1+ and CTLA4+ T cells and other cellular fractions from peripheral blood of cancer patients and healthy volunteers by using specific conjugated antibodies, evaluating their functional ex vivo anti-tumor cytotoxicity against targeted autologous tumor cells.
Gender:
All
Ages:
5 years and above
Trial Updated:
04/26/2022
Locations: Carolina BioOncology Institute, Huntersville, North Carolina
Conditions: Solid Tumor, Adult, Healthy Donors, COVID-19 Donors
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Evaluating a New Program for Successfully Coping With Adversity
NCT05354492
Recruiting
You are invited to participate in a research study involving a new program designed to support people with navigating the changes that can happen after difficult life events. The program activities are aimed at helping you move forward and raise your well-being after experiencing one of life's challenges. This study should not be considered an alternative to any treatment or medication for any disorder or problem.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/25/2022
Locations: Wake Forest University, Winston-Salem, North Carolina
Conditions: Trauma, Distress, Emotional, Psychological Distress
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Introducing Palliative Care (PC) Within the Treatment of End Stage Liver Disease (ESLD)
NCT03540771
Recruiting
This is a comparative effectiveness study of two pragmatic models aiming to introduce palliative care for end stage liver disease patients. The 2 comparators are: Model 1: Consultative Palliative Care (i.e. direct access to Palliative Care provider), Model 2: Trained Hepatologist- led PC intervention (i.e. a hepatologist will receive formal training to deliver Palliative Care services) Primary Outcome: The change in quality of life from baseline to 3 months post enrollment as assessed by FACT-... Read More
Gender:
All
Ages:
Between 18 years and 120 years
Trial Updated:
04/05/2022
Locations: UNC Liver Center, Chapel Hill, North Carolina
Conditions: End Stage Liver Disease
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Study to Evaluate Effects of INL1 in Patients With Heart Failure and Reduced Ejection Fraction
NCT03875183
Recruiting
This is a multicenter, randomized, double-blind, placebo-controlled, dose-response trial in patients with chronic stable Heart Failure (HF) and reduced Left Ventricular Ejection Fraction (LVEF) to evaluate the efficacy and safety of three INL1 doses compared with placebo. Patients will be treated for approximately 12 weeks with one of three INL1 doses: 50 mg, 150 mg, 300 mg, or, placebo capsules, taken twice daily (BID).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/28/2022
Locations: Clinical Research of Gastonia, Gastonia, North Carolina
Conditions: Heart Failure, Reduced Ejection Fraction
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Analysis and Suppression of Tremor During Grasp Using Ultrasound Imaging and Electrical Stimulation
NCT05308368
Recruiting
Individuals experiencing tremors face difficulty performing activities of daily living caused by involuntary oscillation of the muscles in the hands and arms. Current solutions to help suppress tremors include medication, surgery, assistive devices and lifestyle change. However, each of these has a drawback of its own including cost and unwanted side effects. Aside from the solutions listed, it has been shown that functional electrical stimulation(FES) is a possible solution to help suppress tre... Read More
Gender:
All
Ages:
Between 18 years and 90 years
Trial Updated:
03/25/2022
Locations: Engineering Building III, Raleigh, North Carolina
Conditions: Parkinson Disease, Essential Tremor
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Effect of Addition of Steroids on Duration of Analgesia
NCT04126824
Recruiting
The purpose of the study is to investigate the differences in post-procedural pain scores and narcotic use among patients who receive a Superior Hypogastric Nerve Block (SHNB) with and without corticosteroid performed as part of the Uterine Artery Embolization (UAE) procedure.
Gender:
Female
Ages:
Between 30 years and 60 years
Trial Updated:
03/25/2022
Locations: University of North Carolina, Chapel Hill, North Carolina
Conditions: Uterine Fibroids, Adenomyosis
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Next Generation Sequencing Versus Traditional Cultures for Clinically Infected Penile Implants: Impact of Culture Identification on Outcomes
NCT05287438
Recruiting
Randomized prospective study to evaluate next generation sequencing (NGS) and standard-of-care culture for clinically infected penile implants and to compare outcomes with identification of microbes.
Gender:
Male
Ages:
Between 18 years and 80 years
Trial Updated:
03/10/2022
Locations: Duke University, Raleigh, North Carolina
Conditions: Penile Implantation, Infections
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Prospective Global Registry for the Study of Chronic Total Occlusion Intervention
NCT02061436
Recruiting
Percutaneous coronary intervention (PCI) of chronic total occlusions (CTOs) is increasingly being performed in patients with advanced coronary artery disease, but there is limited information on the techniques utilized and the procedural outcomes. The goal of this multicenter, investigator initiated registry is to collect information on treatment strategies and outcomes of consecutive patients undergoing CTO PCI among various participating centers. The information collected will be used to deter... Read More
Gender:
All
Ages:
All
Trial Updated:
03/08/2022
Locations: Carolina East Medical Center, New Bern, North Carolina
Conditions: Coronary Artery Disease
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Minimizing Toxicity in HLA-identical Related Donor Transplantation for Children With Sickle Cell Disease
NCT03587272
Recruiting
This multisite prospective study seeks to determine if HLA-identical sibling donor transplantation using alemtuzumab, low dose total-body irradiation, and sirolimus (Sickle transplant Using a Nonmyeloablative approach, "SUN") can decrease the toxicity of transplant while achieving a high cure rate for children with sickle cell disease (SCD).
Gender:
All
Ages:
Between 2 years and 25 years
Trial Updated:
03/02/2022
Locations: Levine Children's Hospital, Charlotte, North Carolina
Conditions: Sickle Cell Disease
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NOVOCART®3D for Treatment of Articular Cartilage of the Knee
NCT01957722
Recruiting
This study is to compare NOVOCART 3D relative to Microfracture for the treatment of knee cartilage defects. Efficacy will be evaluated by both pain and function. Safety will also be evaluated.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/01/2022
Locations: Duke University, Durham, North Carolina
Conditions: Articular Cartilage of the Femoral Condyle Between 2-6cm2
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