Pennsylvania is currently home to 3297 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Promising ROd-cone DYstrophy Gene TherapY
NCT05748873
Recruiting
This is a two-step, multicenter, Phase I/II study including an open-label dose-escalation phase (Step 1) and a three-arm, controlled, double-masked, randomized extension phase (Step 2), in subjects with advanced RCD due to a mutation in the RHO, PDE6A, or PDE6B gene.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/11/2024
Locations: UPMC Eye Center, Pittsburgh, Pennsylvania
Conditions: Retinitis Pigmentosa
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International CDKL5 Registry
NCT04486768
Recruiting
Owing to the recent classification of CDKL5 Deficiency Disorder (CDD) as a unique disorder, there is a limited understanding of overall disease natural history and meaningful outcome measures. An international patient registry aimed at collecting both patient/caregiver and clinician-entered demographic, patient-reported outcome (PRO) and treatment data would benefit both the scientific and patient communities. This CDD registry will follow up to 500 patients diagnosed with CDD over several years... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/10/2024
Locations: University of Pennsylvania Orphan Disease Center, Philadelphia, Pennsylvania
Conditions: CDKL5 Deficiency Disorder (CDD)
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Pilot Trial of the RUBI Program for Autistic Adults
NCT06593613
Recruiting
The goal of this clinical trial is to evaluate if a redesigned version of the RUBI parenting intervention can reduce challenging behaviors and improve adaptive skills in autistic adults with co-occurring challenging behaviors. The main questions it aims to answer are: * Is the redesigned RUBI intervention feasible and acceptable for autistic adults and their families? * Does the redesigned RUBI intervention reduce challenging behaviors and enhance the quality of life for autistic adults? * Rese... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: A.J. Drexel Autism Institute, Philadelphia, Pennsylvania
Conditions: Autism Spectrum Disorder, Behavior, Parenting
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Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension
NCT06543745
Recruiting
The purpose of the study is to learn more about how low-resistance training impacts frailty and the quality of life of people with pulmonary arterial hypertension (PAH). Low-resistance training is an evidence-based approach that may help patients improve their functional ability.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: University of Pennsyvania, Philadelphia, Pennsylvania
Conditions: Pulmonary Arterial Hypertension, Frailty
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First In Human Study of CX-801 in Advanced Solid Tumors
NCT06462794
Recruiting
The purpose of this first-in-human study, CTMX-801-101, is to characterize the safety, tolerability, and antitumor activity of CX-801 as monotherapy and in combination with pembrolizumab in adult participants with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: University of Pittsburgh Hillman Cancer Center, Pittsburgh, Pennsylvania
Conditions: Solid Tumor, Adult
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Romosozumab Use to Build Skeletal Integrity
NCT05058976
Recruiting
The purpose of this study is to find out if one year of romosozumab (Evenity®), a monthly injection given in the arm under the skin, prior to an infusion of zoledronic acid Reclast®, works to treat bone loss and prevent it from worsening in older women (ages 65 and older) who have osteoporosis and reside in long-term care (LTC) facilities.
Gender:
FEMALE
Ages:
65 years and above
Trial Updated:
09/09/2024
Locations: UPMC Senior Communities, Pittsburgh, Pennsylvania
Conditions: Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Fracture
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Fiber Food Introduction in Pediatric Short Bowel Syndrome
NCT05432648
Recruiting
Short bowel syndrome (SBS) is a rare but challenging condition in which patients have insufficient bowel length to meet fluid, electrolyte, and nutrient requirements without parenteral support. The purpose of this study is to determine how well dietary fiber is tolerated in patients with short bowel syndrome compared to patients without short bowel syndrome based on assessment of gastrointestinal symptoms, and corresponding changes in microbiome composition and metabolomics.
Gender:
ALL
Ages:
Between 4 months and 18 years
Trial Updated:
09/06/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Short Gut Syndrome
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A Trial of Post-Discharge Transitional Care for Patients With Chronic Liver Disease
NCT05733832
Recruiting
Patients with complications of advanced liver disease often have difficulties after hospital discharge that result in early hospital readmission. Poor outcomes for these patients during this transitional time could be improved through the use of innovative transitional care models. This proposal aims to examine the effect of a transitional care model, The Transitional Liver Clinic (TLC), in reducing hospital re-admissions, improving quality of life, and improving patient experience.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/05/2024
Locations: Albert Einstein Healthcare Network, Philadelphia, Pennsylvania
Conditions: Liver Diseases
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Cigarette Packaging of Low Nicotine Cigarettes
NCT03802019
Recruiting
The purpose of this study is to examine the effect of changes in cigarette package color on smoking behaviors, harm exposure, and risk perceptions when using low nicotine content (LNC) cigarettes.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
09/05/2024
Locations: Center for Interdisciplinary Research for Nicotine Addiction, Philadelphia, Pennsylvania
Conditions: Smoking, Cigarette
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A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients with Autoimmune Disease
NCT06587828
Recruiting
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation. These tissues contain both cytotoxic and helper T cells that are driving their disease, and these T cells are being guided by TCRs that recognize tissue-specific targets. By collecting tissue when a patient has active inflammation, it is possible to determine which T cells are activated and undergoing clonal e... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Susquehanna Research Group, Harrisburg, Pennsylvania
Conditions: Autoimmune Diseases, Ulcerative Colitis, Multiple Sclerosis, Scleroderma, Ankylosing Spondylitis, Celiac Disease, Non-radiographic Axial Spondyloarthritis (nr-axSpA), Crohn's Disease, Birdshot Chorioretinitis
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Triheptanoin for Children with Primary-Specific Pyruvate Dehydrogenase Complex (PDC) Deficiency
NCT06340685
Recruiting
This is a medical research study to test a medication in patients with a disease called Pyruvate Dehydrogenase Complex (PDC) Deficiency. The medication is triheptanoin, which is currently FDA approved for the treatment of Long-Chain Fatty Acid Oxidation Disorders. Previous research suggests that triheptanoin may also be effective in the treatment PDC Deficiency. This study will investigate the safety and efficacy (how well it works) of triheptanoin in patients with PDC Deficiency.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
09/04/2024
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pyruvate Dehydrogenase Complex Deficiency
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Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence
NCT05172089
Recruiting
This work is based on DFU patients, seeks to conduct a fully powered clinical study testing i) If DFU with a history of biofilm infection closes with deficient barrier function. ii) whether such functionally deficient wound closure, manifested as high TEWL, is associated with greater wound recurrence. The primary parent study will also address molecular mechanisms implicated in biofilm-induced loss of skin epithelial barrier integrity in DFU patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: UPMC Wound Healing Services at UPMC Passavant, Cranberry Township, Pennsylvania
Conditions: Diabetic Foot, Diabetic Foot Infection, Chronic Wounds, Biofilm Infection, Trans-epidermal Water Loss (TEWL)
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