Pennsylvania is currently home to 3317 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment
NCT06367387
Recruiting
This study seeks to improve the treatment of chronic pain in people who are taking buprenorphine (also known as Suboxone, Subutex, Zubsolv). The research study is testing two different interventions along with usual clinical care: 1. Pain Self-Management (PSM): an educational program in which individuals with chronic pain work with a trained pain coach and a pain peer to explore strategies to effectively manage the daily problems that arise from chronic pain. 2. Patient-Oriented Dosing (POD):... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2024
Locations: UPMC Latterman Family Health Center, McKeesport, Pennsylvania
Conditions: Opioid Use Disorder, Chronic Pain
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Improving Care, Accelerating Recovery and Education
NCT06233747
Recruiting
The goal of this clinical trial is to test the I-CARE program in children who are in a medical hospital awaiting inpatient mental health treatment. The main questions it aims to answer are: * Can the I-CARE program be used at the medical hospitals and do the patients and hospital staff like the program? * Does the I-CARE program lower patients' emotional distress, thoughts about suicide or suicide attempts? Patients will complete as many of the 7 I-CARE videos as possible during their stay at... Read More
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
08/01/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Mental Health Disorder, Suicide Attempt, Suicidal Ideation, Emergency Psychiatric
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Caregiver Stress and Sleep Study
NCT05219955
Recruiting
This study includes a randomized experimental component where therapists will systematically deliver an experimental behavioral probe or a supportive control condition. The aim is to evaluate effects on meaningful health-relevant measures including morning activation levels, depression symptoms, rumination, and aspects brain connectivity previously linked with depression.
Gender:
ALL
Ages:
60 years and above
Trial Updated:
08/01/2024
Locations: UPMC Western Behavioral Health, Pittsburgh, Pennsylvania
Conditions: Depressive Symptoms, Caregiver Burden
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A Study to Determine if the Drug, Pyrvinium Pamoate, is Safe and Tolerable in Patients With Pancreatic Cancer
NCT05055323
Recruiting
This phase I trial studies the side effects and best dose of pyrvinium pamoate for the treatment of pancreatic ductal adenocarcinoma that cannot be removed by surgery (resectable). Pyrvinium pamoate may slow down tumor growth and help patients live longer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/01/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Resectable Pancreatic Ductal Adenocarcinoma, Stage 0 Pancreatic Cancer AJCC v8, Stage I Pancreatic Cancer AJCC v8, Stage IA Pancreatic Cancer AJCC v8, Stage IB Pancreatic Cancer AJCC v8, Stage II Pancreatic Cancer AJCC v8, Stage IIA Pancreatic Cancer AJCC v8, Stage IIB Pancreatic Cancer AJCC v8
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Prospective Research Rare Kidney Stones (ProRKS)
NCT02780297
Recruiting
The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of ren... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/01/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Hyperoxaluria, Cystinuria, Dent Disease, Lowe Syndrome, Adenine Phosphoribosyltransferase Deficiency
Register for Updates
Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
NCT02670707
Recruiting
Langerhans Cell Histiocytosis (LCH) is a type of cancer that can damage tissue or cause lesions to form in one or more places in the body. Langerhans cell histiocytosis (LCH) is a cancer that begins in LCH cells (a type of dendritic cell which fights infection). Sometimes there are mutations (changes) in LCH cells as they form. These include mutations of the BRAF gene. These changes may make the LCH cells grow and multiply quickly. This causes LCH cells to build up in certain parts of the body,... Read More
Gender:
ALL
Ages:
21 years and below
Trial Updated:
08/01/2024
Locations: Lehigh Valley Health Network- Cedar Crest, Allentown, Pennsylvania
Conditions: Langerhans Cell Histiocytosis
Register for Updates
Medical Residents Learning Weight Management Counseling Skills
NCT06529666
Recruiting
The goal of this study is to addresses the lack of weight management training physicians receive during their residency training. The main questions it aims to answer are: * How affective is the MRWeight curriculum at increasing medical residents weight management counseling (WMC) skills. * Evaluate residents' adoption of WMC skills in encounters with their patients * what would be the best way to get residents to adopt the WMC skills Residents in the comparison group will receive a course on o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2024
Locations: Penn State University, Hershey, Pennsylvania
Conditions: Weight Management, Patient Counseling, Video Communication Asssessments
Register for Updates
Apremilast for Erythema Multiforme
NCT05875714
Recruiting
This study is recruiting patients with chronic, treatment resistant erythema multiforme (EM), which is a disease that can affect the skin and mucous membranes (mucocutaneous). EM often impacts quality of life with pain, anorexia, hospitalization, and related long-term issues. While there are medications used to treat EM, no single therapeutic agent has been consistently effective for long-term management of disease. Apremilast (trade name: Otezla) is approved to treat Bechet's Disease, a differe... Read More
Gender:
ALL
Ages:
Between 18 years and 89 years
Trial Updated:
07/30/2024
Locations: Perelman Center For Advanced Medicine, Philadelphia, Pennsylvania
Conditions: Erythema Multiforme
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In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and Paraganglioma
NCT05636540
Recruiting
This study will enroll up to 30 evaluable patients with pheochromocytoma or paraganglioma who are undergoing surgical or systemic treatment. A pre-treatment 18F-FluorThanatrace (\[18F\]FTT) positron emission tomography/computed tomography (PET/CT) scan will be done prior to surgery or systemic therapy. PET/CT imaging will be used to evaluate PARP-1 expression in sites of pheochromocytoma or paraganglioma using the investigational radiotracer \[18F\]FTT. This is an observational study in that \... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/30/2024
Locations: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Pheochromocytoma, Paraganglioma
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Diabetes Reversal and the Subgingival Microbiota
NCT05501093
Recruiting
This study seeks to examine the impact of bariatric surgery on oral bacteria in diabetic compared to non-diabetic patients. The purpose of this research study is to examine how diabetes changes the bacteria in the mouth. This is an important question since bacterial changes may impact oral health. Participants will attend a screening and baseline visit prior to bariatric surgery and three post bariatric surgery appointments (3 weeks post, 6 months post and 1 year to 18 months post). Samples coll... Read More
Gender:
ALL
Ages:
Between 25 years and 65 years
Trial Updated:
07/30/2024
Locations: Temple University, Philadelphia, Pennsylvania
Conditions: Diabetes type2, Bariatric Surgery Candidate
Register for Updates
Self-Management for Head and Neck Lymphedema and Fibrosis [PROMISE Trial]
NCT06125743
Recruiting
The goal of this study is to evaluate the effectiveness of a standardized lymphedema and fibrosis self-management program (LEF-SMP) to improve LEF self-management and reduce LEF-associated symptom burden, functional deficits, and improve quality of life in head and neck cancer (HNC) survivors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Lymphedema of the Head and Neck
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QOL and Sarcopenia in Patients With Ascites
NCT05726747
Recruiting
Clinical data regarding quality of life in patients with refractory ascites is limited and preceded the development of newer questionnaires that may be more robust. One primary objective of this study is to study changes in quality in life in a prospective fashion using newer general and ascites-specific quality of life survey instruments specific to benign and malignant etiologies. Sarcopenia is a condition that is prevalent in cancer and cirrhosis. Current data is retrospective and associativ... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/29/2024
Locations: University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
Conditions: Ascites Hepatic, Ascites, Malignant
Register for Updates