Pennsylvania is currently home to 3301 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Cigarette Packaging of Low Nicotine Cigarettes
NCT03802019
Recruiting
The purpose of this study is to examine the effect of changes in cigarette package color on smoking behaviors, harm exposure, and risk perceptions when using low nicotine content (LNC) cigarettes.
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
09/05/2024
Locations: Center for Interdisciplinary Research for Nicotine Addiction, Philadelphia, Pennsylvania
Conditions: Smoking, Cigarette
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A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients with Autoimmune Disease
NCT06587828
Recruiting
The most clinically meaningful way to discover new targets of T cells in autoimmune diseases is to study the tissues of patients with active autoimmune disease mediated organ inflammation. These tissues contain both cytotoxic and helper T cells that are driving their disease, and these T cells are being guided by TCRs that recognize tissue-specific targets. By collecting tissue when a patient has active inflammation, it is possible to determine which T cells are activated and undergoing clonal e... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: Susquehanna Research Group, Harrisburg, Pennsylvania
Conditions: Autoimmune Diseases, Ulcerative Colitis, Multiple Sclerosis, Scleroderma, Ankylosing Spondylitis, Celiac Disease, Non-radiographic Axial Spondyloarthritis (nr-axSpA), Crohn's Disease, Birdshot Chorioretinitis
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Triheptanoin for Children with Primary-Specific Pyruvate Dehydrogenase Complex (PDC) Deficiency
NCT06340685
Recruiting
This is a medical research study to test a medication in patients with a disease called Pyruvate Dehydrogenase Complex (PDC) Deficiency. The medication is triheptanoin, which is currently FDA approved for the treatment of Long-Chain Fatty Acid Oxidation Disorders. Previous research suggests that triheptanoin may also be effective in the treatment PDC Deficiency. This study will investigate the safety and efficacy (how well it works) of triheptanoin in patients with PDC Deficiency.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
09/04/2024
Locations: UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pyruvate Dehydrogenase Complex Deficiency
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Diabetic Foot Ulcer (DFU) Biofilm Infection and Recurrence
NCT05172089
Recruiting
This work is based on DFU patients, seeks to conduct a fully powered clinical study testing i) If DFU with a history of biofilm infection closes with deficient barrier function. ii) whether such functionally deficient wound closure, manifested as high TEWL, is associated with greater wound recurrence. The primary parent study will also address molecular mechanisms implicated in biofilm-induced loss of skin epithelial barrier integrity in DFU patients.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: UPMC Wound Healing Services at UPMC Passavant, Cranberry Township, Pennsylvania
Conditions: Diabetic Foot, Diabetic Foot Infection, Chronic Wounds, Biofilm Infection, Trans-epidermal Water Loss (TEWL)
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Prospective 4D CTA of BAV Competence
NCT04645862
Recruiting
The study involves annual 4D CTA imaging of the bicuspid aortic valve for a period of 5 years. CTA is often standard of care for BAV patients, but patients in this study will receive a higher radiation dose with a 4D imaging protocol. There may also be patients enrolled in the study who have a 4D CTA for research purposes when a routine CTA is not required for clinical care.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/04/2024
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Bicuspid
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Linking Tau PET to Medial Temporal Lobe Subregions With High Resolution MRI
NCT04251130
Recruiting
The investigators will conduct a tau PET scan in cognitively normal older adults and patients with Mild Cognitive Impairment (MCI), enrolled in the National Alzheimer's Coordinating Center (NACC) study at the University of Pennsylvania's Penn Memory Center/Alzheimer's Disease Core Center (PMC/ADC).
Gender:
ALL
Ages:
60 years and above
Trial Updated:
09/04/2024
Locations: University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania
Conditions: Mild Cognitive Impairment
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Natural History and Advanced Genetic Study of Pyruvate Dehydrogenase Complex Deficiencies
NCT03056794
Recruiting
Children and adults with pyruvate dehydrogenase complex deficiency (PDCD) are participating in a research study seeking to better understand the genetic causes, symptoms, usefulness of current treatments, and outcomes for these disorders. The research project involves completing a questionnaire about the individual or family's medical history and experiences with PDCD, review of medical records by the researchers, and in some cases, advanced genetic testing.
Gender:
ALL
Ages:
All
Trial Updated:
09/04/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Pyruvate Dehydrogenase Complex Deficiency Disease
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Randomized Study of the pdSTIM™ System (Phrenic Nerve to Diaphragm STIMulation) in Failure to Wean Mechanically Ventilated Patients
NCT05998018
Recruiting
This prospective, multi-center, randomized, controlled clinical trial is being conducted to evaluate the safety and efficacy of the pdSTIM System to facilitate weaning from mechanical ventilation through phrenic nerve stimulation. Potential subjects who are on mechanical ventilation for at least four days and have failed at least one weaning attempt will be considered for the study. Those enrolled will be randomized in a 1:1 manner between the treatment group that is standard of care with the pd... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/03/2024
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Ventilator Induced Diaphragm Dysfunction
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PAP for Children With DS and OSAS
NCT04132999
Recruiting
Determine the efficacy of family-informed intervention (INT) vs standard clinical care over a period of twelve months in children with obstructive sleep apnea and Down Syndrome.
Gender:
ALL
Ages:
Between 6 years and 18 years
Trial Updated:
09/03/2024
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Down Syndrome, Obstructive Sleep Apnea
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North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)
NCT01694940
Recruiting
The North American Mitochondrial Disease Consortium (NAMDC) maintains a patient contact registry and tissue biorepository for patients with mitochondrial disorders.
Gender:
ALL
Ages:
All
Trial Updated:
09/03/2024
Locations: The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Mitochondrial Disorders, Mitochondrial Genetic Disorders, Mitochondrial Diseases, Disorder of Mitochondrial Respiratory Chain Complexes, Deletion and Duplication of Mitochondrial DNA
Register for Updates
Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).
NCT04372953
Recruiting
Premature babies often need help immediately after birth to open their lungs to air, start breathing and keep their hearts beating. Opening their lungs can be difficult, and once open the under-developed lungs of premature babies will often collapse again between each breath. To prevent this nearly all premature babies receive some form of mechanical respiratory support to aid breathing. Common to all types of respiratory support is the delivery of a treatment called positive end-expiratory pres... Read More
Gender:
ALL
Ages:
Between 23 weeks and 28 weeks
Trial Updated:
09/02/2024
Locations: Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Lung Injury, Preterm Birth
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Neuroblastoma Biology Study
NCT01587300
Recruiting
Medical scientists want to find better ways to treat neuroblastoma and to find ways to prevent the tumor from growing back. To do this, they need more information about the characteristics of neuroblastoma cells. Therefore, they want to study samples of neuroblastoma tissues and neuroblastoma and normal cells in the blood and bone marrow that may be related to the growth of neuroblastoma cells. Doctors and other medical scientists also want to find better ways to detect and measure neuroblastoma... Read More
Gender:
ALL
Ages:
Between 31 days and 99 years
Trial Updated:
09/01/2024
Locations: Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: Neuroblastoma
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