Pennsylvania is currently home to 3464 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or Ganglioneuroblastoma
Recruiting
This research trial studies biomarkers in tumor tissue samples from patients with newly diagnosed neuroblastoma or ganglioneuroblastoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
Gender:
All
Ages:
30 years and below
Trial Updated:
04/11/2023
Locations: Lehigh Valley Hospital-Cedar Crest, Allentown, Pennsylvania
Conditions: Ganglioneuroblastoma, Localized Resectable Neuroblastoma, Localized Unresectable Neuroblastoma, Regional Neuroblastoma, Stage 4 Neuroblastoma, Stage 4S Neuroblastoma
Screening for High Frequency Malignant Disease
Recruiting
The SHIELD (Screening for High Frequency Malignant Disease) study is a prospective, observational, multi-site basket design trial without randomization. The primary objective of the study is to evaluate the sensitivity and specificity of a blood-based GuardantLUNAR-2 test to detect high frequency cancer in screen-relevant populations.
Gender:
All
Ages:
Between 50 years and 80 years
Trial Updated:
04/10/2023
Locations: Pulmonology Associates Inc., Broomall, Pennsylvania
Conditions: Lung Cancer
Improving Utilization of Lung Cancer Screening in Underserved PA Populations
Recruiting
This study is an interventional study intended to assess the impact of a centralized outreach intervention that includes shared decision-making about lung cancer screening (LCS) in LCS-eligible primary care patients. The study's goal is to increase LCS rates compared to usual care and thus reduce lung cancer deaths.
Gender:
All
Ages:
Between 50 years and 77 years
Trial Updated:
04/10/2023
Locations: Lehigh Valley Health Network, Allentown, Pennsylvania
Conditions: Lung Cancer
ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma
Recruiting
This is a multicenter open-label, randomized, non-comparative, parallel cohort pivotal study of treatment with envafolimab (cohort A and C) or envafolimab combined with ipilimumab (cohort B and D) in patients with locally advanced, unresectable or metastatic undifferentiated pleomorphic sarcoma (UPS)/myxofibrosarcoma (MFS) who have progressed on one or two lines of chemotherapy.
Gender:
All
Ages:
12 years and above
Trial Updated:
04/10/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma
Effects of Heating on Exercise Pressor Reflex in Peripheral Artery Disease: Exercise Ability
Recruiting
The study objectives of this projects are to examine the hypothesis that the sympathetic and blood pressure responses to exercise will be attenuated during and after heat exposure in patients with peripheral artery disease, via altering the sensitivity of the muscle afferent receptors.
Gender:
All
Ages:
Between 21 years and 85 years
Trial Updated:
04/10/2023
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: PAD
Autonomic Control of the Circulation and VDR
Recruiting
The study objective of this project is to examine the mechanisms of the venous distension reflex (VDR) in humans. We hypothesize that COX blockade with ketorolac tromethamine, an intravenous NSAID, will attenuate the muscle sympathetic nerve activity (MSNA) response to limb venous distension. To gain further insight into whether the COX byproducts directly stimulate chemically-sensitive afferents, or enable venodilation and indirectly evoke afferent stimulation, we will measure vein size using 3... Read More
Gender:
All
Ages:
Between 21 years and 35 years
Trial Updated:
04/10/2023
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Venous Distension Reflex, Blood Pressure
The Venous Distension Reflex and Orthostatic Hypertension
Recruiting
This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).
Gender:
All
Ages:
18 years and above
Trial Updated:
04/10/2023
Locations: Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania
Conditions: Blood Pressure
Cortical Excitability in Cyclic Vomiting Syndrome
Recruiting
This exploratory study will determine if there are differences in cortical excitability between patients suffering from cyclic vomiting syndrome (CVS) and healthy control subjects, as assessed by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS).
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
04/07/2023
Locations: University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Cyclic Vomiting Syndrome
Postoperative Gastric Point of Care Ultrasound (G-POCUS) in Abdominal Surgery
Recruiting
The purpose of this research is to determine if gastric point of care ultrasound (G-POCUS) can be used to help clinicians determine when to feed patients or when to insert or remove nasogastric tubes for patients recovering from colorectal or abdominal surgery. Patients enrolled in the intervention group will have G-POCUS exams performed after surgery. The results of the exams will be used to make clinical decisions. Researchers will compare these patients to patients receiving the usual care... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/06/2023
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Ileus Postoperative, Postoperative Nausea and Vomiting
Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)
Recruiting
To collect Tau PET/CT imaging in older adults diagnosed with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) in the Mismatch Prospective Cohort Study (MPC-Tau) study to determine relationship to clinical, cognitive, and other biomarker data. Findings from this study will likely provide insight into the phenotypic variability of Alzheimer's Disease and other related pathologies.
Gender:
All
Ages:
Between 18 years and 120 years
Trial Updated:
04/06/2023
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Alzheimer's Disease
A Phase 2a Study of IV BCV in Subjects With Adenovirus Infection (ATHENA)
Recruiting
The purpose of this study is to determine the Dose from the safety and tolerability of intravenous Brincidofovir (BCV, SyB V-1901) using multiple ascending doses in subjects with Adenovirus infection.
Gender:
All
Ages:
2 months and above
Trial Updated:
04/06/2023
Locations: Research Site, Philadelphia, Pennsylvania
Conditions: Adenovirus Infection
DPX-Survivac and Pembrolizumab With and Without Intermittent Low-Dose Cyclophosphamide, in Subjects With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Recruiting
This is a Phase 2b, randomized, open label study to assess the safety and efficacy of DPX-Survivac and pembrolizumab, with and without low-dose cyclophosphamide (CPA) in subjects with relapsed or refractory DLBCL.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/05/2023
Locations: Allegheny Health Network (AHN) West Penn Hospital, Pittsburgh, Pennsylvania
Conditions: Relapsed Diffuse Large B-cell Lymphoma, Refractory Diffuse Large B-cell Lymphoma