Pennsylvania is currently home to 3390 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Sample Collection Study for the CellMax Life Circulating Tumor Cell and Circulating Tumor DNA Platforms for the Early Detection of Colorectal Cancer and Adenomas
NCT05127096
Recruiting
The purpose of this study is to collect clinical specimens from subjects with a diagnosis of colorectal cancer/advanced adenoma or undergoing a screening colonoscopy and meeting study eligibility criteria.
Gender:
All
Ages:
Between 45 years and 80 years
Trial Updated:
11/09/2021
Locations: CellMax Site M, Camp Hill, Pennsylvania
Conditions: Colorectal Cancer Screening
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Longitudinal Performance of Epi proColon
NCT03218423
Recruiting
This study will evaluate longitudinal performance of Epi proColon with respect to test positivity, longitudinal adherence to Epi proColon screening, adherence to follow-up colonoscopy and diagnostic yield, as well as assay failure rates.
Gender:
All
Ages:
Between 50 years and 74 years
Trial Updated:
10/29/2021
Locations: Geisinger Health System, Danville, Pennsylvania
Conditions: Colorectal Cancer, Colorectal Neoplasms
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Evaluating an Online Wellness Intervention for Greek Adolescents
NCT04815681
Recruiting
The investigators are evaluating the effects of an online single-session mental health intervention (the Common Elements Toolbox; COMET). To evaluate COMET, the investigators are conducting a randomized controlled trial with Greek adolescents attending high school in the Attica region in Greece. Students will be randomized to the COMET condition or to an active control condition. Primary outcome measures (depressive symptoms, anxiety symptoms, subjective well-being) will be measured at two week... Read More
Gender:
All
Ages:
Between 13 years and 20 years
Trial Updated:
10/18/2021
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Depressive Symptoms, Anxiety, Happiness
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Effect of Heartfulness Meditation on Brain Waves and How Calm One Feels During Meditation
NCT04721379
Recruiting
Objectives: To assess the EEG patterns and EKG recordings of participants with no meditation experience with simply closing the eyes for 10 minutes followed by relaxing for 30 minutes. To assess the EEG patterns and EKG recordings of participants with no meditation experience by simply closing the eyes for 10 minutes and then with guided Heartfulness relaxation and meditation for 30 minutes. To assess the baseline anxiety score through GAD-7 questionnaire, subjective experience of all the parti... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/06/2021
Locations: WellSpan Dover Sleep Center, Dover, Pennsylvania
Conditions: Anxiety, Stress
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Impact of Complimentary and Alternative Practices on Patient Wellbeing During Rehabilitation
NCT05082246
Recruiting
The study's objective is to assess whether CAM methods are feasible and beneficial in the WSRH setting; to assess stress (using the Perceived Stress Scale-14 and using BioSquares™), anxiety (using the Generalized Anxiety Disorder-7 scale), depression (using the Patient Health Questionnaire-9 scale), pain (using the Wong-Baker FACES scale), and vital signs using a multidisciplinary complementary approach with Heartfulness Meditation, Conscious Breathing, and Emotional Freedom Technique - the CAM... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/05/2021
Locations: Wellspan Surgery and Rehabilitation Hospital, York, Pennsylvania
Conditions: Anxiety, Depression, Stress, Pain, Heart Rate, Blood Pressure
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CapTem Plus Radioembolization for NET Liver Metastases
NCT04789109
Recruiting
Grade 2 neuroendocrine tumors have an intermediate rate of progression following embolotherapy of liver metastases. The combination of capecitabine and temozolomide has been shown to be an active regimen in this disease. Both drugs are radiosensitizers, and in a safety and feasibility study were combined with yttrium-90 radioembolization with acceptable additive toxicities and better than expected response and duration of disease control. This study expands use of this regimen in a Phase 2 inves... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/01/2021
Locations: Abramson Cancer Center, Philadelphia, Pennsylvania
Conditions: Neuroendocrine Tumor Grade 2, Liver Metastases
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Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
NCT01835028
Recruiting
Low-flow, low-gradient (LF-LG) aortic stenosis (AS) may occur with depressed (i.e. Classical LF; CLF) or preserved (i.e. Paradoxical LF; PLF) LV ejection fraction (LVEF) and both situations are amongst the most challenging encountered in patients with valvular heart disease. Although, CLF-LG AS is recognized has an important clinical entity, current ACC/AHA-ESC guidelines however do not provide precise recommendations for clinical management of these patients . PLF-LG AS is a new entity recently... Read More
Gender:
All
Ages:
Between 21 years and 90 years
Trial Updated:
09/20/2021
Locations: Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Aortic Valve Stenosis
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Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair
NCT03262688
Recruiting
A multicenter, single-dose study in children 12 to <17 years of age, 6 to <12 years of age, and 2 to <6 years of age who are scheduled for elective open inguinal hernia repair. Enrollment in this study will start with the oldest age group (12 to <17 years) and will continue in a stepwise fashion until appropriate doses are established for all 3 pediatric age groups (12 to <17 years, 6 to <12 years, 2 to <6 years).
Gender:
All
Ages:
Between 2 years and 16 years
Trial Updated:
07/23/2021
Locations: Children's Hospital of Pittsburgh of UPMC (CHP-UPMC), Pittsburgh, Pennsylvania
Conditions: Inguinal Hernia, Postoperative Pain
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Prospective US Radiofrequency SUI Trial
NCT04720352
Recruiting
PURSUIT: Prospective US Radiofrequency SUI Trial (VI-17-06) is a prospective, randomized, sham controlled, double blind study in premenopausal women with stress urinary incontinence. The study will be conducted in 390 subjects, randomized 2:1 with active or sham treatment. Study duration is 12 months post treatment. The primary objective is to evaluate the efficacy of the Viveve treatment, SUI protocol, in improving mild to moderate stress urinary incontinence (SUI), assessed using the 1-hour Pa... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/19/2021
Locations: The Clinical Trial Center, LLC, Jenkintown, Pennsylvania
Conditions: Urinary Incontinence, Stress
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PRIME Care (PRecision Medicine In MEntal Health Care) 2.0
NCT04958824
Recruiting
Background: In the last several years, commercial pharmacogenetic (PGx) testing for the selection of psychotropic medications has become widespread as a means of implementing "precision medicine", with some insurers electing to cover the cost of testing. Mostly these efforts have focused on the decision of choosing a medication. Polypharmacy has become widespread and often the norm in patients with more severe of chronic illness. Objectives: This project is designed to evaluate the utility of P... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/06/2021
Locations: Cpl Michael J Crescenz VAMC, Philadelphia, Pennsylvania
Conditions: Psychiatric or Mood Diseases or Conditions
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An Extension Study to Evaluate the Efficacy and Safety of HORIZANT in Adolescents With Moderate-to-Severe Primary RLS
NCT02633683
Recruiting
The objectives of the trial are to evaluate the long-term efficacy and safety of HORIZANT (Gabapentin Enacarbil) 600 mg daily, for the treatment of RLS in adolescents (13 to 17 years of age) diagnosed with moderate-to-severe primary RLS.
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
06/07/2021
Locations: The Sleep Center at the Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: RLS
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Immunity After COVID-19 Vaccination
NCT04883164
Recruiting
The purpose of the research is to evaluate new blood tests, which measure immunity to the COVID-19 coronavirus after vaccination. These tests will be used to measure T-cell and antibody immunity after COVID-19 vaccination. Recent studies show that less than one-fifth of chronically immunosuppressed transplant recipients developed anti-receptor-binding domain antibodies after the first dose of the Pfizer vaccine (Boyarski, 2021). ood sampling at periodic intervals. These samples will be used to... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
05/11/2021
Locations: Plexision, Pittsburgh, Pennsylvania
Conditions: Immunity to COVID-19
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