Pennsylvania is currently home to 3447 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
CapTem Plus Radioembolization for NET Liver Metastases
NCT04789109
Recruiting
Grade 2 neuroendocrine tumors have an intermediate rate of progression following embolotherapy of liver metastases. The combination of capecitabine and temozolomide has been shown to be an active regimen in this disease. Both drugs are radiosensitizers, and in a safety and feasibility study were combined with yttrium-90 radioembolization with acceptable additive toxicities and better than expected response and duration of disease control. This study expands use of this regimen in a Phase 2 inves... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/01/2021
Locations: Abramson Cancer Center, Philadelphia, Pennsylvania
Conditions: Neuroendocrine Tumor Grade 2, Liver Metastases
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Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
NCT01835028
Recruiting
Low-flow, low-gradient (LF-LG) aortic stenosis (AS) may occur with depressed (i.e. Classical LF; CLF) or preserved (i.e. Paradoxical LF; PLF) LV ejection fraction (LVEF) and both situations are amongst the most challenging encountered in patients with valvular heart disease. Although, CLF-LG AS is recognized has an important clinical entity, current ACC/AHA-ESC guidelines however do not provide precise recommendations for clinical management of these patients . PLF-LG AS is a new entity recently... Read More
Gender:
All
Ages:
Between 21 years and 90 years
Trial Updated:
09/20/2021
Locations: Pittsburgh Medical Center, Pittsburgh, Pennsylvania
Conditions: Aortic Valve Stenosis
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Safety, Tolerability, PK, and Analgesic Effect of INL-001 in Children Following Open Inguinal Hernia Repair
NCT03262688
Recruiting
A multicenter, single-dose study in children 12 to <17 years of age, 6 to <12 years of age, and 2 to <6 years of age who are scheduled for elective open inguinal hernia repair. Enrollment in this study will start with the oldest age group (12 to <17 years) and will continue in a stepwise fashion until appropriate doses are established for all 3 pediatric age groups (12 to <17 years, 6 to <12 years, 2 to <6 years).
Gender:
All
Ages:
Between 2 years and 16 years
Trial Updated:
07/23/2021
Locations: Children's Hospital of Pittsburgh of UPMC (CHP-UPMC), Pittsburgh, Pennsylvania
Conditions: Inguinal Hernia, Postoperative Pain
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Prospective US Radiofrequency SUI Trial
NCT04720352
Recruiting
PURSUIT: Prospective US Radiofrequency SUI Trial (VI-17-06) is a prospective, randomized, sham controlled, double blind study in premenopausal women with stress urinary incontinence. The study will be conducted in 390 subjects, randomized 2:1 with active or sham treatment. Study duration is 12 months post treatment. The primary objective is to evaluate the efficacy of the Viveve treatment, SUI protocol, in improving mild to moderate stress urinary incontinence (SUI), assessed using the 1-hour Pa... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/19/2021
Locations: The Clinical Trial Center, LLC, Jenkintown, Pennsylvania
Conditions: Urinary Incontinence, Stress
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PRIME Care (PRecision Medicine In MEntal Health Care) 2.0
NCT04958824
Recruiting
Background: In the last several years, commercial pharmacogenetic (PGx) testing for the selection of psychotropic medications has become widespread as a means of implementing "precision medicine", with some insurers electing to cover the cost of testing. Mostly these efforts have focused on the decision of choosing a medication. Polypharmacy has become widespread and often the norm in patients with more severe of chronic illness. Objectives: This project is designed to evaluate the utility of P... Read More
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
07/06/2021
Locations: Cpl Michael J Crescenz VAMC, Philadelphia, Pennsylvania
Conditions: Psychiatric or Mood Diseases or Conditions
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An Extension Study to Evaluate the Efficacy and Safety of HORIZANT in Adolescents With Moderate-to-Severe Primary RLS
NCT02633683
Recruiting
The objectives of the trial are to evaluate the long-term efficacy and safety of HORIZANT (Gabapentin Enacarbil) 600 mg daily, for the treatment of RLS in adolescents (13 to 17 years of age) diagnosed with moderate-to-severe primary RLS.
Gender:
All
Ages:
Between 13 years and 17 years
Trial Updated:
06/07/2021
Locations: The Sleep Center at the Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania
Conditions: RLS
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Immunity After COVID-19 Vaccination
NCT04883164
Recruiting
The purpose of the research is to evaluate new blood tests, which measure immunity to the COVID-19 coronavirus after vaccination. These tests will be used to measure T-cell and antibody immunity after COVID-19 vaccination. Recent studies show that less than one-fifth of chronically immunosuppressed transplant recipients developed anti-receptor-binding domain antibodies after the first dose of the Pfizer vaccine (Boyarski, 2021). ood sampling at periodic intervals. These samples will be used to... Read More
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
05/11/2021
Locations: Plexision, Pittsburgh, Pennsylvania
Conditions: Immunity to COVID-19
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Online Wellness Intervention for College Students
NCT04740411
Recruiting
We are evaluating the effects of an online single-session mental health intervention (the Common Elements Toolbox; COMET). To evaluate COMET, we are conducting a randomized controlled trial with college students attending American universities. Students will be randomized to the COMET condition or to a wait-list control condition.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/11/2021
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Depression, Anxiety, Well-being
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Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies, the PROCEED Study
NCT04753255
Recruiting
This study gathers information on patients at different stages of chronic pancreatitis to better understand the natural course and risk factors associated with pancreatitis. Chronic pancreatitis is a disease that occurs when the pancreas is inflamed (swollen and irritated) all of the time. It is important for doctors to diagnose chronic pancreatitis in the beginning stages of the disease. Over time, as chronic pancreatitis gets worse, the pancreas may stop working correctly. Since treatment opti... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/22/2021
Locations: University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania
Conditions: Acute Pancreatitis, Chronic Pancreatitis
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CyberKnife Dose Escalation Prostate Cancer Trial
NCT03822494
Recruiting
Stereotactic body radiation therapy (SBRT) has been employed in the treatment of prostate cancer. Multiple single institution experiences suggest high biochemical control rates with acceptable toxicity in low risk prostate cancer but efficacy data in unfavorable type prostate cancer is less convincing. CyberKnife-SBRT (CK-SBRT) can be used to escalate radiation dose delivery to the prostate while sparing normal tissue.
Gender:
Male
Ages:
18 years and above
Trial Updated:
04/19/2021
Locations: Crozer Keystone Health System/Philadelphia CyberKnife Center, Havertown, Pennsylvania
Conditions: Prostate Cancer, Prostate Adenocarcinoma, Prostate Neoplasm
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Attachment-Based Family Therapy for Adolescents With Binge Eating
NCT04779801
Recruiting
The purpose of this study is to examine whether Attachment-Based Family Therapy (ABFT), a well-validated treatment for adolescents with depression and suicidality, is feasible and acceptable for adolescents with binge eating and their families.
Gender:
All
Ages:
Between 12 years and 22 years
Trial Updated:
03/02/2021
Locations: Drexel University, Philadelphia, Pennsylvania
Conditions: Bulimia Nervosa, Binge-Eating Disorder, Other Specified Feeding or Eating Disorder
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Conversion of Seddon III Nerve Injury to Seddon I/II Nerve Injury
NCT03236064
Recruiting
This study will evaluate the safety and efficacy of PEG 3350 for use in nerve repair.
Gender:
All
Ages:
Between 16 years and 65 years
Trial Updated:
01/22/2021
Locations: WellSpanYork Hospital, York, Pennsylvania
Conditions: Injury of Other Nerves at Wrist and Hand Level of Unspecified Arm, Initial Encounter
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