Pennsylvania is currently home to 3464 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Semantic Feature Analysis Treatment for Aphasia
Recruiting
This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/14/2022
Locations: VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania
Conditions: Aphasia
Evaluating the Effects of Tasimelteon vs. Placebo in Delayed Sleep-Wake Phase Disorder (DSWPD)
Recruiting
This is a multicenter, double-blind, randomized study to evaluate the efficacy and safety of a daily single oral dose of tasimelteon and matching placebo in male and female participants with DSWPD.
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
01/12/2022
Locations: Vanda Investigational Site, Danville, Pennsylvania
Conditions: Sleep Wake Disorders, Sleep Disorders, Circadian Rhythm, Chronobiology Disorders
The EMPOWER Study: Endometriosis Diagnosis Using microRNA
Recruiting
Endometriosis is a complex, heterogeneous disease that may present inconsistently across women. Using disease-specific biomarkers and advanced biostatistics, DotLab is developing a biomarker test to confirm the presence of endometriosis.This is a multi-center, prospective, observational, minimal risk study in women undergoing laparoscopy, laparotomy or other pelvic surgical procedure for endometriosis, infertility or another benign gynecological indication. Participants will undergo 2 study visi... Read More
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
01/11/2022
Locations: Penn State Health, Hershey, Pennsylvania
Conditions: Endometriosis
CGX1321 in Subjects With Advanced Solid Tumors and CGX1321 With Pembrolizumab or Encorafenib + Cetuximab in Subjects With Advanced GI Tumors (Keynote 596)
Recruiting
This is a multicenter, open-label study conducted in two phases: Phase 1 consisting of a CGX1321 Single Agent Dose Escalation Phase in solid tumors, CGX1321 Single Agent Dose Expansion Phase in GI tumors and Roll-over Cohort of CGX1321 and pembrolizumab in subjects who have progressed on single agent CGX1321 and Phase 1b consisting of CGX1321 in combination with pembrolizumab in colorectal tumors and CGX1321 in combination with encorafenib + cetuximab in BRAFV600E mutated colorectal tumors. Both... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
01/11/2022
Locations: Gettysburg Cancer Center, Gettysburg, Pennsylvania
Conditions: Solid Tumors, GI Cancer
Safety and Durability of Sirolimus for Treatment of LAM
Recruiting
The MIDAS study aims to follow LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung cysts.
Gender:
Female
Ages:
18 years and above
Trial Updated:
01/11/2022
Locations: University of Pennsylvania Medical Center, Philadelphia, Pennsylvania
Conditions: Lymphangioleiomyomatosis
Prospective Evaluation and Comparison of Bilateral Synergy Implants and Bilateral PanOptix Implants
Recruiting
The purpose of this study is to evaluate the AcrySof PanOptix Intraocular Lens (IOL) for binocular distance corrected near visual acuity (DCNVA) compared to TECNIS Synergy IOL. Presbyopia correcting diffractive intraocular implants (extended depth of focus, multifocal, and trifocal) provide cataract and refractive surgeons with an effective treatment means for allowing patients to experience increased spectacle independence post-cataract surgery.
Gender:
All
Ages:
22 years and above
Trial Updated:
01/10/2022
Locations: Eye Care Specialists, Kingston, Pennsylvania
Conditions: Cataract
Investigating How Incentives Impact Engagement With an Online Mental Health Application (Neuroflow)
Recruiting
The purpose of the study is to understand how incentives (either points alone or points that can be exchanged for gift certificates) encourage engagement with an online mental health app (Neuroflow) for University students. Overall, the hope of this study is to help the investigators understand how best to support mental health and wellness in university students.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/13/2021
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Behavioral Economics, Gifts, Financial, Point
Sample Collection Study for the CellMax Life Circulating Tumor Cell and Circulating Tumor DNA Platforms for the Early Detection of Colorectal Cancer and Adenomas
Recruiting
The purpose of this study is to collect clinical specimens from subjects with a diagnosis of colorectal cancer/advanced adenoma or undergoing a screening colonoscopy and meeting study eligibility criteria.
Gender:
All
Ages:
Between 45 years and 80 years
Trial Updated:
11/09/2021
Locations: CellMax Site M, Camp Hill, Pennsylvania
Conditions: Colorectal Cancer Screening
Longitudinal Study of Neurodegenerative Disorders
Recruiting
The purpose of this study is to understand the course of rare genetic disorders that affect the brain. This data is being analyzed to gain a better understanding of the progression of the rare neurodegenerative disorders and the effects of interventions.
Gender:
All
Ages:
All
Trial Updated:
11/02/2021
Locations: The Program for the Study of Neurodevelopment in Rare Disorders, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania
Conditions: MLD, Krabbe Disease, ALD, MPS I, MPS II, MPS III, Vanishing White Matter Disease, GM3 Gangliosidosis, PKAN, Tay-Sachs Disease, NP Deficiency, Osteopetrosis, Alpha-Mannosidosis, Sandhoff Disease, Niemann-Pick Diseases, MPS IV, Gaucher Disease, GAN, GM1 Gangliosidoses, Morquio Disease, S-Adenosylhomocysteine Hydrolase Deficiency, Batten Disease, Pelizaeus-Merzbacher Disease, Leukodystrophy, Lysosomal Storage Diseases, Purine Nucleoside Phosphorylase Deficiency, Multiple Sulfatase Deficiency Disease
Longitudinal Performance of Epi proColon
Recruiting
This study will evaluate longitudinal performance of Epi proColon with respect to test positivity, longitudinal adherence to Epi proColon screening, adherence to follow-up colonoscopy and diagnostic yield, as well as assay failure rates.
Gender:
All
Ages:
Between 50 years and 74 years
Trial Updated:
10/29/2021
Locations: Geisinger Health System, Danville, Pennsylvania
Conditions: Colorectal Cancer, Colorectal Neoplasms
Evaluating an Online Wellness Intervention for Greek Adolescents
Recruiting
The investigators are evaluating the effects of an online single-session mental health intervention (the Common Elements Toolbox; COMET). To evaluate COMET, the investigators are conducting a randomized controlled trial with Greek adolescents attending high school in the Attica region in Greece. Students will be randomized to the COMET condition or to an active control condition. Primary outcome measures (depressive symptoms, anxiety symptoms, subjective well-being) will be measured at two week... Read More
Gender:
All
Ages:
Between 13 years and 20 years
Trial Updated:
10/18/2021
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Depressive Symptoms, Anxiety, Happiness
Effect of Heartfulness Meditation on Brain Waves and How Calm One Feels During Meditation
Recruiting
Objectives: To assess the EEG patterns and EKG recordings of participants with no meditation experience with simply closing the eyes for 10 minutes followed by relaxing for 30 minutes. To assess the EEG patterns and EKG recordings of participants with no meditation experience by simply closing the eyes for 10 minutes and then with guided Heartfulness relaxation and meditation for 30 minutes. To assess the baseline anxiety score through GAD-7 questionnaire, subjective experience of all the parti... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
10/06/2021
Locations: WellSpan Dover Sleep Center, Dover, Pennsylvania
Conditions: Anxiety, Stress