Virginia is currently home to 1820 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Terumo Aortic Global Endovascular Registry
NCT04246463
Recruiting
Multi-arm, multi-center, open label, prospective observational registry designed to obtain safety and performance data on the use of CE marked and custom Terumo Aortic endovascular grafts.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/19/2023
Locations: Sentara Heart Hospital, Norfolk, Virginia
Conditions: Abdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Surgery
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A Study of Orally Administered JBI-802, an LSD1/HDAC6 Inhibitor, in Patients With Advanced Solid Tumors
NCT05268666
Recruiting
The purpose of this study is to determine the maximum-tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of JBI-802 in patients with Advanced Solid Tumors.The efficacy of the RP2D will be evaluated in phase 2 in patients with solid tumors of neuroendocrine differentiation.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/12/2023
Locations: NEXT Virginia, LLC, Fairfax, Virginia
Conditions: Locally Advanced Solid Tumor, Metastatic Solid Tumor
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Simplified Post Op Rehabilitation for Ankle and Pilon Fractures
NCT05280639
Recruiting
The aim of this study is to compare standard post operative rehabilitation with a simplified wooden block stretching protocol that will yield similar results.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/18/2023
Locations: University of Virginia Medical Center, Charlottesville, Virginia
Conditions: Ankle Fractures, Pilon Fracture
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Optimizing Ultrasound-induced Anti-inflammation in Human Subjects
NCT05685108
Recruiting
This is a feasibility study to determine whether pulsed ultrasound stimulation targeting the splenic nerve or the cervical vagus nerve can elicit an anti-inflammatory immune response in healthy volunteers.
Gender:
ALL
Ages:
Between 25 years and 50 years
Trial Updated:
05/15/2023
Locations: University of Virginia, Division of Nephrology; Center for Immunity, Inflammation & Regenerative Medicine, Charlottesville, Virginia
Conditions: Healthy Subjects
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Impact of Reading on Endogenous Oxytocin System of Preterm Infants
NCT05412524
Recruiting
The purpose of this study is to learn how early language exposure may be related to changes in DNA in parents and their premature infants. While a person's genetic code is determined at the time of conception, the way that some genes are expressed in the body can be changed even after an individual is born. These changes are called epigenetic changes. In this study, the investigators want to learn about the epigenetic changes that happen after a premature baby is born and whether a parent's inte... Read More
Gender:
ALL
Ages:
33 weeks and below
Trial Updated:
05/15/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Premature Infant Disease, Development, Infant
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Study of Immune Globulin Intravenous (Human) GC5107 in Pediatric Subjects With Primary Humoral Immunodeficiency
NCT04565015
Recruiting
The purpose of this study is to evaluate the pharmacokinetics and safety of Immune Globulin Intravenous (Human) GC5107 in pediatric subjects with Primary Humoral Immunodeficiency (PHID).
Gender:
ALL
Ages:
Between 2 years and 16 years
Trial Updated:
05/15/2023
Locations: Lysosomal and Rare Disorders Research and Treatment Center, Inc., Fairfax, Virginia
Conditions: Primary Immune Deficiency
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Effects of Obesity and Intensity of Exercise on Ghrelin Levels
NCT04581980
Recruiting
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin sensitivity, obesity, and vascular function.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
05/08/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Obesity, Insulin Resistance, Cardiovascular Risk Factor
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Low-Intensity Focused Ultrasound for Cocaine Use Disorder
NCT05857852
Recruiting
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings. Data analysis will serve to show if 1) LIFU is safe and effective and to 2) examine the effects of LIFU on dAI BOLD activity and craving in response to cocaine cue-exposure. The study will screen 60 individuals with Cocaine Use Disorder (CUD) to arrive at 30 enrolled subjects, based on a 2:1 screen/... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/04/2023
Locations: UVA Center for Leading Edge Addiction Research, Charlottesville, Virginia
Conditions: Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
Register for Updates
Intravesical Photodynamic Therapy ("PDT") in BCG-Unresponsive/Intolerant Non-Muscle Invasive Bladder Cancer ("NMIBC") Patients
NCT03945162
Recruiting
This is a phase II, open-label, single-arm, multi-center Study conducted in Canada and the United States. Patients with NMIBC CIS (with or without resected papillary disease (Ta, T1)) that are considered Bacillus Calmette-Guerin ("BCG")-Unresponsive or who are intolerant to BCG therapy. BCG-Unresponsive is at least one of the following: At least five of six doses of an initial induction course plus at least two of three doses of maintenance therapy; or, at least five of six doses of an initial i... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/27/2023
Locations: Site 02-009 - Virginia Urology, Richmond, Virginia
Conditions: Non-Muscle Invasive Bladder Cancer ("NMIBC") Unresponsive/Intolerant to BCG
Register for Updates
Platelet Adhesion in the Pathobiology of Aortic Stenosis
NCT05550896
Recruiting
Aortic stenosis (AS) is a serious and common condition that affects 2-3% of the population \>65 years of age in Western countries. It is also responsible for extraordinarily high healthcare expenditures, estimated to be over $6 billion annually,2 in part because the primary treatment for severe AS is aortic valve replacement (AVR) which is resource-intensive. Valve abnormalities are frequently recognized before AS becomes severe, or before there is need for guideline-directed procedural interven... Read More
Gender:
ALL
Ages:
25 years and above
Trial Updated:
04/18/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Aortic Valve Stenosis
Register for Updates
A Phase I/II Dose Escalation and Expansion Study of BST-236 Plus Venetoclax in Patients With Unfit Newly Diagnosed AML
NCT05503355
Recruiting
An open label multi centre study to assess the safety and efficacy of BST-236 in combination with venetoclax in adult patients unfit for standard therapy with newly diagnosed Acute Myeloid Leukemia (AML) Part 1 of the study will define the maximal tolerate dose of the combination treatment, while part 2 will expend the chosen dose, to assesses efficacy and safety of this combination. All patients will receive 2 induction courses with both BST-236 and venetoclax, responding patients will then be... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
04/02/2023
Locations: University of Virginia Cancer Center, Charlottesville, Virginia
Conditions: AML, Adult
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HR-EGG in Medically Refractory Gastroparesis
NCT05789511
Recruiting
The goal of this observational study is to utilize a novel high resolution electrogastrography device to gauge if identification of gastric dysarrythmias can reliably identify patients that will respond to or will require definitive pyloric interventions such as a G-POEM procedure in patients with medically refractory gastroparesis Aims: 1. Assess for the presence of gastric dysarrythmias in lung transplantation population as compared to alternative etiologies of gastroparesis 2. Assess if pre... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Gastroparesis, Lung Transplant; Complications
Register for Updates