Virginia is currently home to 1865 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Management of Antiplatelet Regimen During Surgical Procedures
NCT03981835
Recruiting
There are key differences today in clinical practice regarding perioperative management of post-PCI patients on DAPT undergoing NCS. Moreover, there are significant differences between bridging agents, and improved safety of current-generation DES. Given the significant limitations of current studies a well-designed registry to study current U.S. practice patterns and the bleeding or ischemic risks associated with the various perioperative DAPT management strategies including bridging and no bri... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2023
Locations: Mary Washington Hospital, Fredericksburg, Virginia
Conditions: Cardiac Surgery, Surgery, Percutaneous Coronary Intervention, Surgery--Complications
Register for Updates
Optimizing Pain Self-Management in Total Knee Arthroplasty
NCT06038240
Recruiting
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee arthroplasty (TKA). The scientific premise is that patient use of a positive emotion generative practice - savoring meditation, which has been demonstrated to reduce pain in experimental laboratory settings, enhanced with a pain neuroscience education component about reward syste... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/29/2023
Locations: Fontaine Research Park, Charlottesville, Virginia
Conditions: Osteo Arthritis Knee, Knee Pain Chronic, Surgery
Register for Updates
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
NCT06009276
Recruiting
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle. This study is trying to find out if fitness status impacts the bacteria that are present in the oral microbiome (environment in the mouth) or the ability of the body to send blood to the skeletal muscle. Participants will complete all or some of the following: * A mouth swab to assess the bacteria in their mouths. * Produce a saliva sample into a tube. * Cycle on a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/28/2023
Locations: UVA Student Health and Wellness Building, Charlottesville, Virginia
Conditions: Heart Failure, Systolic, Heart Failure, Diastolic, Peripheral Arterial Disease, Overweight and Obesity
Register for Updates
The Use of Memantine for Prevention of Alzheimer's Disease
NCT05063851
Recruiting
As the US population ages, the prevalence of dementia is increasing, and Alzheimer's Disease (AD) is the most prevalent one. Solving the Alzheimer's Disease (AD) epidemic is likely to require preventive therapy beginning many years before symptoms are expected to be evident in at-risk individuals. AD is caused by the dysfunction, loss of synapses, and eventual neuronal death, which may occur up to 25 years before clinical symptoms appear. This study, based off of pre-clinical data, seeks to asse... Read More
Gender:
ALL
Ages:
Between 50 years and 65 years
Trial Updated:
11/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Alzheimer Disease
Register for Updates
The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion During Exercise in Patients With PAD
NCT05036213
Recruiting
Peripheral arterial disease (PAD) is a highly prevalent and costly condition. Intermittent claudication (IC), defined as ischemic leg pain that occurs with walking, results in functional impairment, reduced daily physical activity, and a lower quality of life. Although the mechanisms contributing to functional impairment are not fully delineated, current evidence suggests that the uncoupling of skeletal muscle cellular metabolism from tissue perfusion may be responsible for exercise intolerance.... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Peripheral Arterial Disease, Peripheral Vascular Diseases
Register for Updates
Minds Navigating the Diagnosis of Mild Cognitive Impairment
NCT05690243
Recruiting
The goal of this clinical trial is to find out if a 9 week group therapy using video from home will help veterans with Mild Cognitive Impairment (MCI). The main questions it aims to answer are: * is the video therapy user-friendly for veterans? * does it improve veterans well-being and quality-of-life? Veterans will be asked to attend nine 1 hour small group video sessions and will complete questionnaires before and after the sessions. Researchers will compare the group of veterans that start... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
11/20/2023
Locations: Salem VA Medical Center, Salem, Virginia
Conditions: Cognitive Dysfunction, Mild Cognitive Impairment
Register for Updates
Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy
NCT00680264
Recruiting
The purpose of this study is to determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
11/20/2023
Locations: Kluge Children's Rehab. Ctr., Charlottesville, Virginia
Conditions: Cerebral Palsy, Scoliosis
Register for Updates
Use of Harmonic Scalpel to Decrease Lymphatic and Chest Tube Drainage After Lymph Node Dissection With Lobectomy.
NCT00591552
Recruiting
In an effort to elucidate whether the Harmonic Scalpel will improve sealing lymphatics and decrease lymphatic drainage thereby decreasing the length of time that chest tubes are required and minimizing length of stay; the Harmonic Scalpel will be compared to a control group which uses electrocautery. This study will assess these two different methods to determine if there is a notable decrease in the amount of drainage with one versus the other.
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
11/20/2023
Locations: Sentara Norfolk General Hospital/Sentara Heart Hospital, Norfolk, Virginia
Conditions: Lung Cancer
Register for Updates
PrEP Intervention Among Black Sexual Minority Men
NCT06141408
Recruiting
The goal of the proposed research is to design a peer-based community intervention focused on addressing internalized homophobia, internalized racism, HIV stigma, and peer BSMM support to increase PrEP initiation among BSMM in Prince George's County, MD. Participants will attend intervention events focused on stigma reduction and building community among Black queer men. Researchers will compare intervention and control group participants to see if there in a difference in PrEP initiation and ad... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: George Mason University, Fairfax, Virginia
Conditions: Hiv, Mental Health Issue, Support, Family
Register for Updates
Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
NCT04597099
Recruiting
This study is trying to find out if flutamide (a medication that blocks the effects of testosterone) may help normalize an aspect of pituitary function (specifically, gonadotropin surge generation) in PCOS. This is a randomized, placebo-controlled, double-blinded, crossover study. The investigators hypothesize that in estradiol-pretreated women with PCOS, acute progesterone augmentation of FSH release (positive feedback) will be enhanced by flutamide.
Gender:
FEMALE
Ages:
Between 18 years and 30 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: PCOS, Polycystic Ovary Syndrome
Register for Updates
Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age
NCT03905941
Recruiting
The goal of this study is to determine the relative desirability of metformin vs. oral combined hormonal contraceptives (OCs) in treating Polycystic Ovary Syndrome (PCOS) in women of later reproductive age. Polycystic Ovary Syndrome Questionnaire (PCOSQ) score will be used as a proxy for patient satisfaction. In light of their respective effects on the classic and metabolic facets of PCOS, metformin will provide non-inferior patient satisfaction compared to OCs in later reproductive age women wi... Read More
Gender:
FEMALE
Ages:
Between 40 years and 49 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
Register for Updates
Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS
NCT03905603
Recruiting
The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone \[LH\] secretion, ovarian response to recombinant human chorionic gonadotropin \[r-hCG\] administration, adrenal response to adrenocorticotropic hormone \[ACTH\] administration, and hyperinsulinemia) in older vs. young women with Polycystic Ovary Syndrome (PCOS) in a cross-sectional, physiological study. The investigators hypothesize that hyperinsulinemia... Read More
Gender:
FEMALE
Ages:
Between 20 years and 49 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
Register for Updates