Virginia is currently home to 1861 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The Use of Memantine for Prevention of Alzheimer's Disease
NCT05063851
Recruiting
As the US population ages, the prevalence of dementia is increasing, and Alzheimer's Disease (AD) is the most prevalent one. Solving the Alzheimer's Disease (AD) epidemic is likely to require preventive therapy beginning many years before symptoms are expected to be evident in at-risk individuals. AD is caused by the dysfunction, loss of synapses, and eventual neuronal death, which may occur up to 25 years before clinical symptoms appear. This study, based off of pre-clinical data, seeks to asse... Read More
Gender:
ALL
Ages:
Between 50 years and 65 years
Trial Updated:
11/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Alzheimer Disease
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The Effects of Oral Inorganic Nitrate Supplementation on Lower Limb Perfusion During Exercise in Patients With PAD
NCT05036213
Recruiting
Peripheral arterial disease (PAD) is a highly prevalent and costly condition. Intermittent claudication (IC), defined as ischemic leg pain that occurs with walking, results in functional impairment, reduced daily physical activity, and a lower quality of life. Although the mechanisms contributing to functional impairment are not fully delineated, current evidence suggests that the uncoupling of skeletal muscle cellular metabolism from tissue perfusion may be responsible for exercise intolerance.... Read More
Gender:
ALL
Ages:
Between 40 years and 80 years
Trial Updated:
11/28/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Peripheral Arterial Disease, Peripheral Vascular Diseases
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Minds Navigating the Diagnosis of Mild Cognitive Impairment
NCT05690243
Recruiting
The goal of this clinical trial is to find out if a 9 week group therapy using video from home will help veterans with Mild Cognitive Impairment (MCI). The main questions it aims to answer are: * is the video therapy user-friendly for veterans? * does it improve veterans well-being and quality-of-life? Veterans will be asked to attend nine 1 hour small group video sessions and will complete questionnaires before and after the sessions. Researchers will compare the group of veterans that start... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
11/20/2023
Locations: Salem VA Medical Center, Salem, Virginia
Conditions: Cognitive Dysfunction, Mild Cognitive Impairment
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Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy
NCT00680264
Recruiting
The purpose of this study is to determine the radiographic and clinical outcomes of Scoliosis surgical and non-operative treatment in patients with Cerebral Palsy.
Gender:
ALL
Ages:
Between 8 years and 21 years
Trial Updated:
11/20/2023
Locations: Kluge Children's Rehab. Ctr., Charlottesville, Virginia
Conditions: Cerebral Palsy, Scoliosis
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Use of Harmonic Scalpel to Decrease Lymphatic and Chest Tube Drainage After Lymph Node Dissection With Lobectomy.
NCT00591552
Recruiting
In an effort to elucidate whether the Harmonic Scalpel will improve sealing lymphatics and decrease lymphatic drainage thereby decreasing the length of time that chest tubes are required and minimizing length of stay; the Harmonic Scalpel will be compared to a control group which uses electrocautery. This study will assess these two different methods to determine if there is a notable decrease in the amount of drainage with one versus the other.
Gender:
ALL
Ages:
Between 20 years and 75 years
Trial Updated:
11/20/2023
Locations: Sentara Norfolk General Hospital/Sentara Heart Hospital, Norfolk, Virginia
Conditions: Lung Cancer
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PrEP Intervention Among Black Sexual Minority Men
NCT06141408
Recruiting
The goal of the proposed research is to design a peer-based community intervention focused on addressing internalized homophobia, internalized racism, HIV stigma, and peer BSMM support to increase PrEP initiation among BSMM in Prince George's County, MD. Participants will attend intervention events focused on stigma reduction and building community among Black queer men. Researchers will compare intervention and control group participants to see if there in a difference in PrEP initiation and ad... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/15/2023
Locations: George Mason University, Fairfax, Virginia
Conditions: Hiv, Mental Health Issue, Support, Family
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Androgen Blockade and Progesterone Augmentation of Gonadotropin Secretion
NCT04597099
Recruiting
This study is trying to find out if flutamide (a medication that blocks the effects of testosterone) may help normalize an aspect of pituitary function (specifically, gonadotropin surge generation) in PCOS. This is a randomized, placebo-controlled, double-blinded, crossover study. The investigators hypothesize that in estradiol-pretreated women with PCOS, acute progesterone augmentation of FSH release (positive feedback) will be enhanced by flutamide.
Gender:
FEMALE
Ages:
Between 18 years and 30 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: PCOS, Polycystic Ovary Syndrome
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Relative Desirability of Metformin vs. Birth Control Pill in Treating PCOS in Women of Later Reproductive Age
NCT03905941
Recruiting
The goal of this study is to determine the relative desirability of metformin vs. oral combined hormonal contraceptives (OCs) in treating Polycystic Ovary Syndrome (PCOS) in women of later reproductive age. Polycystic Ovary Syndrome Questionnaire (PCOSQ) score will be used as a proxy for patient satisfaction. In light of their respective effects on the classic and metabolic facets of PCOS, metformin will provide non-inferior patient satisfaction compared to OCs in later reproductive age women wi... Read More
Gender:
FEMALE
Ages:
Between 40 years and 49 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
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Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS
NCT03905603
Recruiting
The objective of the study is to determine the relative contributions of four established predictors of hyperandrogenism (luteinizing hormone \[LH\] secretion, ovarian response to recombinant human chorionic gonadotropin \[r-hCG\] administration, adrenal response to adrenocorticotropic hormone \[ACTH\] administration, and hyperinsulinemia) in older vs. young women with Polycystic Ovary Syndrome (PCOS) in a cross-sectional, physiological study. The investigators hypothesize that hyperinsulinemia... Read More
Gender:
FEMALE
Ages:
Between 20 years and 49 years
Trial Updated:
11/01/2023
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome
Register for Updates
Assessment of Day-night Secretion of Progesterone and LH Across Puberty
NCT02155933
Recruiting
Hormones are substances that are made by the body and are sent directly out into the bloodstream to increase or decrease the function of certain organs, glands, or other hormones. Testosterone is a hormone found in the blood of all girls, but some girls have too much testosterone in their blood. Too much testosterone in the blood can possibly lead to a problem called polycystic ovary syndrome (PCOS). People with PCOS have abnormal menstrual periods, excess facial and body hair, and too much test... Read More
Gender:
FEMALE
Ages:
Between 7 years and 17 years
Trial Updated:
11/01/2023
Locations: Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia
Conditions: Puberty, Hyperandrogenism
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Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone
NCT01428089
Recruiting
During childhood, the levels of certain hormones: gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone are very low. However, when puberty starts, GnRH and LH pulses begin to increase, but they initially do so at night only. It is unknown why GnRH and LH pulses increase at night and then decrease during the day (instead of being increased all the time). The purpose of this study is to see how quickly progesterone reduces... Read More
Gender:
FEMALE
Ages:
Between 7 years and 14 years
Trial Updated:
11/01/2023
Locations: Center for Research in Reproduction, University of Virginia, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome, Hyperandrogenism, Normal Puberty
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Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?
NCT04075149
Recruiting
Adolescent girls with androgen excess have a higher rate of irregular periods and decreased ovulation rates compared to normal girls, and are considered at-risk for developing polycystic ovary syndrome (PCOS). This pilot study will look at whether giving spironolactone might improve ovulation rates in girls with androgen excess, ages 13-19. If this is true, spironolactone treatment to young girls might prevent PCOS from developing and avoid future infertility.
Gender:
FEMALE
Ages:
Between 13 years and 19 years
Trial Updated:
10/25/2023
Locations: University of Virginia Center for Research in Reproduction, Charlottesville, Virginia
Conditions: Polycystic Ovary Syndrome, Puberty Disorders, Ovulation Disorder
Register for Updates