Virginia is currently home to 1850 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Too Much of a Good Thing? Impact of Initial Prescription Size in Post-cesarean Section Pain Management
NCT05360433
Recruiting
This is a randomized controlled trial involving 170 opioid naive women ages 19-40 undergoing scheduled C-sections at Carilion Roanoke Memorial Hospital. Participants are randomized to receive either 10 or 20 tabs of oxycodone 5mg as an initial postoperative prescription in a double-blinded parallel trial design. Outcome metrics related to overall opioid consumption and patient satisfaction with pain management are collected at three different time points post-operative: 2-3 days (in hospital), 1... Read More
Gender:
Female
Ages:
Between 19 years and 40 years
Trial Updated:
04/29/2022
Locations: Carilion Roanoke Memorial Hospital, Roanoke, Virginia
Conditions: Post Operative Pain
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Assessing the Bioavailability of Leading Phytonutrient Products
NCT05349032
Recruiting
This study will primarily test various phytonutrient-based supplements to see which gets absorbed into the body the best. The study will secondarily look at inflammatory markers in the urine to determine any change.
Gender:
Male
Ages:
Between 21 years and 49 years
Trial Updated:
04/21/2022
Locations: David Roberts, Charlottesville, Virginia
Conditions: Inflammation
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Robotic Hand Orthosis Providing Grasp Assistance for Patients With Brachial Plexus Injuries
NCT04939233
Recruiting
The proposed research, the development of an innovative robotic hand orthosis with intelligent grasping control, is relevant to public health as it will restore a large measure of functionality to the paralyzed hand of a person who has suffered a brachial plexus injury. The proposed orthosis will utilize novel technology that will result in a device that is compact, portable, dexterous, and intuitively controllable while overcoming the disadvantages of previously developed orthoses that rendered... Read More
Gender:
All
Ages:
Between 18 years and 69 years
Trial Updated:
04/07/2022
Locations: Carilion Clinic Institute for Orthopaedics and Neurosciences, Roanoke, Virginia
Conditions: Brachial Plexus Injury
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Study to Evaluate the Pharmacodynamics and Efficacy of Leuprolide Tablets (Ovarest®) in Women With Endometriosis
NCT05096065
Recruiting
The pharmacodynamic endpoint of percentage of subjects with suppressed estradiol level (less than 20 pg/mL) on cycle day 29 is the primary endpoint of the study.
Gender:
Female
Ages:
Between 18 years and 49 years
Trial Updated:
03/21/2022
Locations: Tidewater Clinical Research, Norfolk, Virginia
Conditions: Endometriosis
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Durvalumab in Different Combinations With Pralatrexate, Romidepsin and Oral 5-Azacitidine for Lymphoma
NCT03161223
Recruiting
This is an open-label, Phase 1/2a, dose-finding study with an initial phase 1 portion, articulated in four separate treatment arms, followed by a dedicated phase 2 for qualifying treatment Arm(s). The primary objective of the Phase 1 portion is to determine the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of the combinations of: Durvalumab, oral 5-azacitidine, and romidepsin (Arm A); durvalumab, pralatrexate, and romidepsin (Arm B); durvalumab and romidepsin (Arm C); or durvalu... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/16/2022
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Lymphoma, T-Cell
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Laryngeal Nerve Block for Chronic Cough
NCT05292677
Recruiting
The purpose of this study is to study the potential benefit of treating chronic neurogenic cough by blocking the nerve responsible for the disease with an injection of local anesthetic/steroid mixture versus a placebo.
Gender:
All
Ages:
18 years and above
Trial Updated:
03/14/2022
Locations: Eastern Virginia Medical School Ear, Nose, and Throat Surgeons, Norfolk, Virginia
Conditions: Laryngeal Nerve Block, Chronic Neurogenic Cough, Laryngeal Hypersensitivity
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Surviving PEA in Roanoke (SPEAR) Study
NCT05283850
Recruiting
The Carilion Clinic and Virginia Tech Carilion School of Medicine, in conjunction with Roanoke Fire-EMS, Botetourt County Department of Fire & EMS and Salem Fire-EMS, are studying the outcomes of patients experiencing Pulseless Electrical Activity (PEA). PEA refers to a type of cardiac arrest in which there is normal electrical activity in the heart however the heart still fails to contract to generate a pulse. Without heart contractions, which normally generates a pulse, the brain and other imp... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2022
Locations: Carilion Clinic, Roanoke, Virginia
Conditions: Cardiac Arrest, Pulseless Electrical Activity
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Home OCT Fluid Visualization Agreement Study
NCT04907409
Recruiting
This is a single arm study of home monitoring with the NVHO for 5 weeks with office visits at enrollment, Week 1 and Week 5 (Exit Visit) and, when applicable, Interim Visit(s) triggered by ongoing review by the Reading Center. The study will enroll subjects diagnosed with NV-AMD in at least one eye with attention to the proportion of eyes with IRF and/or SRF. The enrolled eligible subjects will be instructed to self-image the study eye(s) once daily for 5 weeks using a NVHO device at home with s... Read More
Gender:
All
Ages:
55 years and above
Trial Updated:
03/08/2022
Locations: Wagner Macula & Retina Center, Norfolk, Virginia
Conditions: Neovascular Age-related Macular Degeneration
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PEN-866 in Patients With Advanced Solid Malignancies
NCT03221400
Recruiting
Protocol PEN-866-001 is an open-label, multi-center, first-in-human Phase 1/2a study evaluating PEN-866 in patients with advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/16/2022
Locations: Virginia Cancer Specialists, Fairfax, Virginia
Conditions: Carcinoma, Endometrial Adenocarcinoma, Neoplasms, Squamous Cell Carcinoma of the Anus, Adenocarcinoma of the Pancreas, Advanced Cancer, Solid Tumor, Solid Carcinoma, Squamous Cell Carcinoma of the Cervix, Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Vulva, Squamous Cell Carcinoma of the Penis, Gastric Cancer, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Small-cell Lung Cancer, Small Cell Lung Carcinoma, Pancreatic Ductal Adenocarcinoma, Pancreatic Adenocarcinoma
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Effects of Empagliflozin on Cardiac Microvasculature and Insulin Sensitivity in Subjects With Type 2 Diabetes
NCT04203927
Recruiting
The aim is to test in T2DM patients, whether, compared to placebo, 12 weeks of SGLT-2 inhibitor improves post-absorptive, post-insulin infusion or postprandial insulin action to enhance Cardiac Muscle vascular function and whether changes correlate with improved GV or postprandial hyperglycemia
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
02/09/2022
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Type2 Diabetes, Insulin Sensitivity
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Utility of Ultrasound-Guided Site Marking in Pediatric Lumbar Punctures
NCT04828746
Recruiting
The standard way to identify landmarks in the spine before inserting a needle for a lumbar puncture is to feel by touch. The purpose of this research is to determine if doing an ultrasound to identify landmarks before performing a lumbar puncture will improve the first-time success rate of the needle insertion in pediatric patients.
Gender:
All
Ages:
17 years and below
Trial Updated:
01/24/2022
Locations: Carilion Roanoke Memorial Hospital, Roanoke, Virginia
Conditions: Ultrasound Therapy; Complications
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COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age
NCT05149300
Recruiting
The primary objective of the study is to characterize the concentrations of casirivimab+imdevimab in serum over time after a single subcutaneous (SC) administration The secondary objectives of the study are: To assess the safety and tolerability of SC or single administration of casirivimab+imdevimab To assess the occurrence of grade ≥3 injection site reactions and grade ≥3 hypersensitivity reactions, in participants treated with SC doses of casirivimab+imdevimab To assess the immunogenicity o... Read More
Gender:
All
Ages:
12 years and below
Trial Updated:
12/06/2021
Locations: Regeneron Research Site, Richmond, Virginia
Conditions: COVID-19
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