There are currently 283 active clinical trials seeking participants for Cancer research studies. The states with the highest number of trials for Cancer participants are California, Texas, New York and Florida.
A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations
NCT05588141
Recruiting
Background: Diffuse gliomas are tumors that affect the brain and spinal cord. Gliomas that develop in people with certain gene mutations (IDH1 or IDH2) are especially aggressive. Better treatments are needed. Objective: To see if a study drug (zotiraciclib) is effective in people with recurrent diffuse gliomas who have IDH1 or IDH2 mutations. Eligibility: People aged 15 years and older with diffuse gliomas that returned after treatment. They must also have mutations in the IDH1 or IDH2 gene... Read More
Gender:
ALL
Ages:
15 years and above
Trial Updated:
03/21/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Brain Tumor, Cancer
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Implement and Test Visual Consent Template and Process
NCT06804837
Recruiting
The investigators plan to conduct a stepped wedge randomized control trial to implement and test the consent template and process in three studies. Randomization will occur at the research coordinator/research team level. Each participating research team member will begin in the standard consent arm of the study. Subsequently, they will be randomized to the visual key information page arm at staggered time points to undergo training and begin using the visual key information page with patients w... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/20/2025
Locations: Washington University School of Medicine, Saint Louis, Missouri +2 locations
Conditions: Cancer, Alzheimer Disease
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Registry Study to Evaluate the Clinical Outcome of Cancer Patients and Benign Diseases Treated with Radiation
NCT03617237
Recruiting
Registry database repository for determining clinical outcomes primarily of patients who have received or have been evaluated for radiation treatment in either the definitive or palliative setting for both malignant and benign etiologies. To compare the outcomes with National Cancer Data Base (NCDB) of the American College of Surgeon(ACS).
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/20/2025
Locations: UT Southwestern Medical Centre, Dallas, Texas
Conditions: Cancer
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INTERogating Cancer for Etiology, Prevention and Therapy Navigation
NCT06008392
Recruiting
This study is being done to identify markers and causes of cancer by analyzing patient's DNA (i.e., genetic material), RNA, plasma, tissues, or other samples that could be informative for patients with cancer. Cancer genetic testing is a series of tests that finds specific changes in cancer cells and normal cells in the body. Researchers may request to access these data as they explore how to better prevent, screen, or treat cancer. This study is also being done to create a biobank (library) of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Mayo Clinic in Arizona, Scottsdale, Arizona +2 locations
Conditions: Cancer, Cancer Gene Mutation, PAN Gene Mutation, Hematopoietic and Lymphoid System Neoplasm, Malignant Solid Neoplasm
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Patient Descriptors of Cancer-Related Fatigue: a Mixed Methods Pilot Study of Cancer Survivors
NCT06634381
Recruiting
The purpose of this research study is to better understand how cancer-related fatigue affects patients and how it's discussed with providers. This information will be used to develop an educational resource (visual aid poster) that could help individuals and their providers talk about cancer-related fatigue and which may help individuals better manage this symptom.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Levine Cancer Institute, Charlotte, North Carolina +1 locations
Conditions: Cancer, Fatigue
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Pleuroscopy First Versus Thoracentesis First in Patients with Suspected Malignant Pleural Effusions
NCT06892691
Recruiting
This is a randomized control trial of patients with suspected malignant pleural effusions to compare whether patients who have a thoracentesis or pleuroscopy (pleural biopsy) obtain an adequate biopsy, achieve a diagnosis, and begin cancer-directed therapy faster.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: Mount Sinai West, New York, New York +1 locations
Conditions: Pleural Effusion, Cancer
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Rehabilitation Outcomes Study
NCT06674889
Recruiting
This pilot health services interventional study aims to prospectively assess the effectiveness of a pre-treatment rehabilitation (prehabilitation) program across a diverse cohort of adult cancer patients via a randomized pilot trial. Upon screening and identification of high-risk features through a central navigation process, patients referred to oncology clinics will be approached to participate in tailored prehabilitation interventions. The study will track and analyze functional outcomes and... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/19/2025
Locations: The N.C. Cancer Hospital, Chapel Hill, North Carolina
Conditions: Cancer, Malignant Tumor
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Isa-Rd for Frail and/or Much Older Patients With Newly Diagnosed Multiple Myeloma
NCT05145400
Recruiting
This research study is investigating the safety and effectiveness of using combination of isatuximab, lenalidomide and dexamethasone for the treatment of newly diagnosed multiple myeloma (MM). The study team will use lower doses than is currently standard for these drugs. Lower doses will be used to avoid or possibly reduce any unwanted side effects commonly associated with these drugs. Using lower doses of the combination isatuximab, lenalidomide and dexamethasone, has not been approved by the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/18/2025
Locations: University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina +2 locations
Conditions: Multiple Myeloma, Cancer
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Met Non Small Cell Cancer Registry (MOMENT)
NCT05376891
Recruiting
The purpose of this multi-national disease registry is to collect prospectively (with longitudinal follow-up) high-quality, standardized, and contemporaneous data to capture changes in the non-small cell lung cancer (NSCLC) treatment landscape and outcomes over time. The registry will capture data on participants; demographic, clinical characteristics (including biomarker data), treatment patterns, and effectiveness and safety outcomes for advanced NSCLC with mesenchymal-epithelial transition e... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/18/2025
Locations: Holy Cross Health, Fort Lauderdale, Florida +63 locations
Conditions: Cancer
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Massage Impact on Sleep in Pediatric Oncology
NCT06892158
Recruiting
This study aims to determine the impact of massage therapy for pediatric patients receiving intensive chemotherapy or stem cell transplant (SCT).
Gender:
ALL
Ages:
Between 12 years and 21 years
Trial Updated:
03/18/2025
Locations: Children's National Hospital, Washington, District of Columbia +1 locations
Conditions: Cancer, Pediatric Cancer, Chemotherapy Effect, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Pediatric, Hematopoietic Stem Cell Transplantation (HSCT)
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Addressing Tetrachloroethylene Exposure in an Impacted Community
NCT05819996
Recruiting
Groundwater in Martinsville, IN, is contaminated by volatile organic compounds (VOCs), tetrachloroethylene (PCE) and trichloroethylene (TCE). Indoor air in some residential and commercial buildings is also contaminated with PCE and TCE. This study is being conducted to better understand the impact of low-level exposures to these compounds on community members' health. Data collected in this study will be used to help the community identify a course of action.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
03/15/2025
Locations: Purdue University, West Lafayette, Indiana
Conditions: Vapors; Inhalation, Cancer, Volatile Organic Compounds
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Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer
NCT05297734
Recruiting
This cluster-randomized comparative effectiveness trial compares a technology-based supportive cancer care (SCC) approach with a redesigned team-based supportive cancer care (SCC) approach.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/15/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +16 locations
Conditions: End of Life, Cancer
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