Maryland is currently home to 2693 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma
NCT05989230
Recruiting
The purpose of this single-arm trial is to determine the feasibility of emotional awareness and expression therapy (EAET) for individuals with persistent pain following orthopedic trauma. As part of this study, participants will be asked to attend weekly EAET treatment sessions and complete assessments (including pre-treatment, post-treatment, and follow-up) consisting of questionnaires and sensory testing procedures.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Orthopaedic Trauma, Chronic Pain, Musculoskeletal Injury
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Feasibility of Brief Behavioral Therapy for Insomnia (BBTI) in SUD Recovery
NCT05935735
Recruiting
The goal of this clinical study is to learn whether treating sleep problems is helpful in people with substance abuse problems who are living in a residential treatment program. Another goal is to study whether treating sleep problems will help individuals stay in substance abuse recovery treatment for a greater amount of time. Participants will be asked to complete surveys at the time of enrollment and every week for the next 9 weeks for a total of 8 times. Participants will be asked to wear a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/10/2024
Locations: Cornerstone at Helping Up Mission Clinic, Baltimore, Maryland
Conditions: Substance Use Disorders, Insomnia
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Cervical Paraspinal Muscle Twitching and Cervical Facet Radiofrequency Ablation Outcomes
NCT05450679
Recruiting
The investigators aim to determine whether cervical paravertebral muscle twitching during motor testing as part of performing cervical RFAs is associated with a greater likelihood of treatment success, and greater magnitude or duration of analgesia. The investigators propose a straightforward grading scale based on visual and tactile information readily available during RFA procedures as part of routine practice (per radiofrequency electrode: 0 = no twitches palpated or observed; 1 = twitches pa... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/09/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Cervical Facet Joint Pain, Chronic Pain, Neck Pain
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TDCS to Improve Post-Stroke Cognitive Impairment
NCT05195398
Recruiting
The investigators will conduct a randomized, double-blinded, sham-controlled trial of approximately 60 patients with minor stroke and post-stroke mild cognitive impairment (psMCI). Participants will be individually randomized on enrollment using a random number generator to treatment with anodal tDCS + computerized cognitive treatment (CCT) versus sham + CCT (approximately 30 patients in each arm). Clinical evaluation including assessment of cognition will be performed pre- and post-intervention... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
09/09/2024
Locations: Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Conditions: Stroke, Stroke Sequelae, Cognitive Impairment
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PET Dynamics to Response-Adapted Neoadjuvant Therapy in TNBC
NCT06245889
Recruiting
Eligible patients with stage 2 and 3 triple negative breast cancer will be treated with 4 cycles of neoadjuvant paclitaxel/carboplatin/pembrolizumab. A PET scan will be performed at baseline and after 1 cycle of therapy. A breast MRI will be performed after treatment completion. Patients with complete clinical response will proceed to surgery. Patients with clinical residual disease will complete neoadjuvant rescue with 4 cycles of doxorubicin/cyclophosphamide prior to surgery. If residual disea... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
09/06/2024
Locations: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland
Conditions: Triple Negative Breast Cancer
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Comparing Single Versus Repeat NMT on the Diversity of the Neonatal Nasal Microbiome
NCT06283355
Recruiting
This study aims to determine whether a parent-to-child nasal microbiota transplant (NMT) can seed and engraft parental organisms into the neonatal microbiome and increase the neonatal microbiome diversity.
Gender:
ALL
Ages:
Between 0 years and 60 years
Trial Updated:
09/05/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Staphylococcus Aureus, Microbial Colonization, Neonatal Infection
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Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone
NCT05282550
Recruiting
To investigate the effect of trazodone on sleep, hippocampal-dependent memory and hippocampal excitability. The investigators hypothesize that trazodone will improve total sleep time and proportion of time in Slow Wave Sleep (SWS).
Gender:
ALL
Ages:
55 years and above
Trial Updated:
09/05/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: AMCI - Amnestic Mild Cognitive Impairment, Sleep Disturbance
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Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome
NCT04717427
Recruiting
Individuals with Sturge-Weber Syndrome (SWS) sometimes have brain involvement which can result in seizures, stroke-like episodes and neurologic deficits. The purpose of this study is to integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. The research aims are: 1. To integrate longitudinal clinical data, radiological data, and blood biomarkers of Sturge-Weber syndrome patients. 2. Identify plasma and imaging biomarkers sensitive to ex... Read More
Gender:
ALL
Ages:
All
Trial Updated:
09/04/2024
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Sturge-Weber Syndrome
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Dose Response of Epinephrine
NCT02692313
Recruiting
Epinephrine is the principal physiologic defense against hypoglycemia in type 1 and longer duration type 2 DM. Despite this, it is unknown how epinephrine regulates in-vivo endothelial function and atherothrombotic balance in humans. The specific aim of our study will be to determine the dose response effects of the key ANS counterregulatory hormone epinephrine on endothelial function, fibrinolytic balance and pro-atherogenic inflammatory mechanisms in healthy humans.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/04/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Diabetes Complications
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Differing Levels of Hypoglycemia
NCT02445781
Recruiting
Hypoglycemia can produce a spectrum of pro-inflammatory and pro-atherothrombotic changes. To date no studies appear to have investigated the effects of differing levels of hypoglycemia on the vasculature and pro-atherothrombotic balance during hypoglycemia in healthy man. The specific aim of our study will be to determine the effects of differing levels of hypoglycemia on in-vivo vascular biologic mechanisms in a healthy population.
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
09/04/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Hypoglycemia
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Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)
NCT01672255
Recruiting
Exercise is a cornerstone of diabetes management. It helps reduce blood pressure, promote weight loss, lower insulin resistance and improve glucose and lipid (triglyceride and HDL-cholesterol) profiles. Unfortunately, the benefits of exercise are often not embraced by diabetic individuals because of the fear of low blood sugar (hypoglycemia). My laboratory has demonstrated that Autonomic nervous system (ANS) counterregulatory failure plays an important role in exercise associated hypoglycemia in... Read More
Gender:
ALL
Ages:
Between 18 years and 45 years
Trial Updated:
09/04/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Type 1 Diabetes, Hypoglycemia Associated Autonomic Failure
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Itacitinib With High-dose Posttransplantation Cyclophosphamide in Older Patients
NCT05823571
Recruiting
This research is being done to learn whether drug called itacitinib, which is a novel inflammation- and immune-lowering drug (immunosuppressant), can be given before and after non-myeloablative peripheral blood stem cell transplantation (PBSCT; also known as a 'mini' transplant) to help prevent certain complications such as cytokine release syndrome (CRS) for patients with blood cancers, using peripheral blood from a relative. The investigators will also examine if by using itacitinib the invest... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
09/03/2024
Locations: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland
Conditions: Leukemia, Acute, Myelodysplastic Syndromes, Myelomonocytic Leukemia, Chronic, T-cell Prolymphocytic Leukemia, CML, Myeloproliferative Disorders, Multiple Myeloma, Plasma Cell Leukemia
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