Pennsylvania is currently home to 3447 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Philadelphia, Pittsburgh, Hershey and Allentown. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
PrEP Awareness, Barriers and Facilitators for PrEP Uptake, and Dosing Mechanisms on Willingness to Take PrEP Among MSM
NCT04719364
Recruiting
The investigators are conducting a one and one-half year mixed-methods study to evaluate self-reported sexual risk, knowledge and barriers/facilitators of PrEP use, and preferences of oral, injectable, and implantable PrEP treatment modalities-as a function of race and age, and experience with intersectional discrimination. The first qualitative phase of our study would be conducted over the first eight months, followed by a quantitative phase that will collect data via online cross-sectional su... Read More
Gender:
Male
Ages:
18 years and above
Trial Updated:
01/20/2021
Locations: Drexel Dornsife School of Public Health, Philadelphia, Pennsylvania
Conditions: PrEP, Discrimination, Racial, Stigma, Social
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An Active and Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis
NCT04718818
Recruiting
The present study D5272C00001 (Legacy # 3151-201-008) seeks to evaluate the efficacy and safety of brazikumab versus placebo in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
01/19/2021
Locations: Research Site, Uniontown, Pennsylvania
Conditions: Ulcerative Colitis
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Prevention of Postoperative Nausea and Vomiting After Bariatric Surgery
NCT04644445
Recruiting
Postoperative nausea and vomiting are common occurrences following bariatric surgery, occurring in up to 80% of patients and contributing to increased healthcare utilization and delays in discharge. This study aims to evaluate the impact of a high-protein liquid diet on postoperative nausea, vomiting, and length of stay after laparoscopic or robotic sleeve gastrectomy.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/07/2020
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Bariatric Surgery Candidate, Postoperative Nausea and Vomiting, Morbid Obesity
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Restoring Non-Emergent Cardiovascular Care in the Peri- COVID-19 Era
NCT04636021
Recruiting
Pre-procedure and Short-Term COVID-19 Testing of Outpatients Undergoing Non-emergent Invasive Cardiovascular Procedures
Gender:
All
Ages:
All
Trial Updated:
11/18/2020
Locations: UPMC Pinnacle Harrisburg, Harrisburg, Pennsylvania
Conditions: Corona Virus Infection
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Spinal Cord Injury Registry - North American Clinical Trials Network
NCT00178724
Recruiting
The NACTN Spinal Cord Injury Registry is a network of clinical centers collecting de-identified data from patients admitted through the Emergency Department of a NACTN center at the time of injury with an initial (first time) spinal cord injury (SCI). Information will be collected on the natural history of SCI and course of treatment through the first 12 months from the date of injury or long as medically indicated. Data collected includes imaging information from CT or MRI scans, neurological a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/22/2020
Locations: Thomas Jefferson University, Philadelphia, Pennsylvania
Conditions: Spinal Cord Injury
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Temsirolimus Alone or Paired With Dexamethasone Delivered to the Adventitia to eNhance Clinical Efficacy After Femoropopliteal Revascularization
NCT03942601
Recruiting
This is a prospective, multi-center, pilot feasibility study to document the effects of adventitial delivery of temsirolimus or temsirolimus with dexamethasone sodium phosphate injection, USP, after revascularization of femoropopliteal lesions in symptomatic patients with moderate to severe claudication (Rutherford 2-3) or critical limb ischemia (CLI) with rest pain (Rutherford 4). Subjects will be followed for up to 60 months post index procedure.
Gender:
All
Ages:
Between 18 years and 85 years
Trial Updated:
08/31/2020
Locations: Einstein Medical Center, Philadelphia, Pennsylvania
Conditions: Peripheral Arterial Disease
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Comparison of the Short-Term Effect of Dietary Carbohydrate Restriction Versus Exogenous Ketone Supplementation on Myocardial Glucose Suppression and Timing to Achieve a State of Ketosis Using FDG PET/CT Serial Imaging
NCT04275453
Recruiting
The purpose of this study is to test different methods of preparation that can be used prior to a test called an FDG PET/CT scan. FDG PET/CT scans are routinely done for evaluation of heart inflammation. Standard preparation for the scan includes a ketogenic (high fat and low carbohydrate) diet for 24 hours and overnight fasting to help suppress the amount of sugar taken up in the heart muscle. However, Investigator still do not know if this preparation is the most effective method. So the Inves... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
07/15/2020
Locations: University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Healthy
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VENOUS: A Translational Study of Enterococcal Bacteremia
NCT04410276
Recruiting
The purpose of this study is to assemble a multicenter prospective cohort of patients with enterococcal bloodstream infections (BSIs) to provide data on outcomes of patients with enterococcal BSIs for sample size calculations for future trials, as well as to characterize enterococcal isolates causing BSIs in order to comprehensively dissect the molecular epidemiology of infecting organisms for future studies.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/26/2020
Locations: University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Conditions: Enterococcal Bacteremia
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Cerclage for Twins With Short Cervical Length ≤ 15mm
NCT03340688
Recruiting
This is a multicenter randomized study designed to determine if ultrasound indicated cerclage reduces the incidence of spontaneous preterm birth <34 weeks in asymptomatic women with twin gestations and cervical length ≤15mm, diagnosed by transvaginal ultrasound between 16 to 23 6/7 weeks of gestation.
Gender:
Female
Ages:
Between 18 years and 60 years
Trial Updated:
04/23/2020
Locations: Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
Conditions: Twin Pregnancy With Antenatal Problem, Preterm Birth, Short Cervix
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Randomized Trial of the Neochord DS1000 System Versus Open Surgical Repair
NCT02803957
Recruiting
The objective of this trial is to assess the safety and effectiveness of the study device in subjects with degenerative mitral valve disease receiving a mitral valve repair without cardiopulmonary bypass (treatment group) when compared to subjects receiving mitral valve repair using standard surgical techniques with cardiopulmonary bypass (control group).
Gender:
All
Ages:
21 years and above
Trial Updated:
12/04/2019
Locations: Pinnacle Health, Harrisburg, Pennsylvania
Conditions: Mitral Valve Insufficiency
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Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates
NCT03495024
Recruiting
To test the feasibility of studying effects of smoking cessation with varenicline on antipsychotic drug-induced neurological side effects, we propose a 12 week pilot study of smoking cessation treatment with varenicline in 10 schizophrenia or schizoaffective disorder patients who are actively smoking and have pre-existing TD while receiving stable doses of antipsychotics. Subjects will be followed after a 2 week baseline period to assess changes in smoking status and neurological symptoms using... Read More
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
03/20/2019
Locations: Corporal Michael J Crescenz VA Medical Center, Philadelphia, Pennsylvania
Conditions: Schizophrenia, Schizoaffective Disorder, Tobacco Smoking, Tardive Dyskinesia, Parkinsonism
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DS vs SIPS-Bariatric Surgery Comparasion
NCT03236142
Recruiting
The aim of this study is to answer the question of whether the single anastomosis, 300 cm loop, duodenal switch (SIPS) is an equally effective, safe, simpler operation with less nutritional and surgical risks than the standard duodenal switch (DS) operation. Please note, this study does not provide a stipend or coverage for surgery.
Gender:
All
Ages:
Between 20 years and 65 years
Trial Updated:
08/31/2018
Locations: Reading Health Physician Network Weight Management Center, West Reading, Pennsylvania
Conditions: Bariatric Surgery Candidate
Register for Updates