Virginia is currently home to 1860 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Richmond, Charlottesville, Norfolk and Fairfax. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Surviving PEA in Roanoke (SPEAR) Study
NCT05283850
Recruiting
The Carilion Clinic and Virginia Tech Carilion School of Medicine, in conjunction with Roanoke Fire-EMS, Botetourt County Department of Fire & EMS and Salem Fire-EMS, are studying the outcomes of patients experiencing Pulseless Electrical Activity (PEA). PEA refers to a type of cardiac arrest in which there is normal electrical activity in the heart however the heart still fails to contract to generate a pulse. Without heart contractions, which normally generates a pulse, the brain and other imp... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
03/08/2022
Locations: Carilion Clinic, Roanoke, Virginia
Conditions: Cardiac Arrest, Pulseless Electrical Activity
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Home OCT Fluid Visualization Agreement Study
NCT04907409
Recruiting
This is a single arm study of home monitoring with the NVHO for 5 weeks with office visits at enrollment, Week 1 and Week 5 (Exit Visit) and, when applicable, Interim Visit(s) triggered by ongoing review by the Reading Center. The study will enroll subjects diagnosed with NV-AMD in at least one eye with attention to the proportion of eyes with IRF and/or SRF. The enrolled eligible subjects will be instructed to self-image the study eye(s) once daily for 5 weeks using a NVHO device at home with s... Read More
Gender:
All
Ages:
55 years and above
Trial Updated:
03/08/2022
Locations: Wagner Macula & Retina Center, Norfolk, Virginia
Conditions: Neovascular Age-related Macular Degeneration
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NOVOCART®3D for Treatment of Articular Cartilage of the Knee
NCT01957722
Recruiting
This study is to compare NOVOCART 3D relative to Microfracture for the treatment of knee cartilage defects. Efficacy will be evaluated by both pain and function. Safety will also be evaluated.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
03/01/2022
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Articular Cartilage of the Femoral Condyle Between 2-6cm2
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PEN-866 in Patients With Advanced Solid Malignancies
NCT03221400
Recruiting
Protocol PEN-866-001 is an open-label, multi-center, first-in-human Phase 1/2a study evaluating PEN-866 in patients with advanced solid malignancies whose disease has progressed after treatment with previous anticancer therapies.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/16/2022
Locations: Virginia Cancer Specialists, Fairfax, Virginia
Conditions: Carcinoma, Endometrial Adenocarcinoma, Neoplasms, Squamous Cell Carcinoma of the Anus, Adenocarcinoma of the Pancreas, Advanced Cancer, Solid Tumor, Solid Carcinoma, Squamous Cell Carcinoma of the Cervix, Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Vulva, Squamous Cell Carcinoma of the Penis, Gastric Cancer, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Small-cell Lung Cancer, Small Cell Lung Carcinoma, Pancreatic Ductal Adenocarcinoma, Pancreatic Adenocarcinoma
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Effects of Empagliflozin on Cardiac Microvasculature and Insulin Sensitivity in Subjects With Type 2 Diabetes
NCT04203927
Recruiting
The aim is to test in T2DM patients, whether, compared to placebo, 12 weeks of SGLT-2 inhibitor improves post-absorptive, post-insulin infusion or postprandial insulin action to enhance Cardiac Muscle vascular function and whether changes correlate with improved GV or postprandial hyperglycemia
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
02/09/2022
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Type2 Diabetes, Insulin Sensitivity
Register for Updates
Utility of Ultrasound-Guided Site Marking in Pediatric Lumbar Punctures
NCT04828746
Recruiting
The standard way to identify landmarks in the spine before inserting a needle for a lumbar puncture is to feel by touch. The purpose of this research is to determine if doing an ultrasound to identify landmarks before performing a lumbar puncture will improve the first-time success rate of the needle insertion in pediatric patients.
Gender:
All
Ages:
17 years and below
Trial Updated:
01/24/2022
Locations: Carilion Roanoke Memorial Hospital, Roanoke, Virginia
Conditions: Ultrasound Therapy; Complications
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SP16 as a Therapeutic for COVID-19 Induced ARDS
NCT05135624
Recruiting
This randomized, double-blind, placebo-controlled, Phase 1b study evaluates the safety and tolerability, and effects on cytokine and acute phase reactants of SP16, an anti-inflammatory drug, in patients with pneumonia due to SARS-CoV-2 infection. The study will enroll up to 20 patients and each eligible patient will be randomized to receive either one of two doses of SP16 (6 mg or 12 mg) or placebo by subcutaneous injection.
Gender:
All
Ages:
18 years and above
Trial Updated:
12/10/2021
Locations: UVA Health Center, Charlottesville, Virginia
Conditions: SARS CoV 2 Infection, Pneumonia
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COVID-19 Administration of Single-Dose Subcutaneous Anti- Spike(s) SARS-CoV-2 Monoclonal Antibodies Casirivimab and Imdevimab in High-Risk Pediatric Participants Under 12 Years of Age
NCT05149300
Recruiting
The primary objective of the study is to characterize the concentrations of casirivimab+imdevimab in serum over time after a single subcutaneous (SC) administration The secondary objectives of the study are: To assess the safety and tolerability of SC or single administration of casirivimab+imdevimab To assess the occurrence of grade ≥3 injection site reactions and grade ≥3 hypersensitivity reactions, in participants treated with SC doses of casirivimab+imdevimab To assess the immunogenicity o... Read More
Gender:
All
Ages:
12 years and below
Trial Updated:
12/06/2021
Locations: Regeneron Research Site, Richmond, Virginia
Conditions: COVID-19
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RCT: Early Feeding After PEG Placement
NCT04110613
Recruiting
Randomized controlled trial to establish evidence on which to base timing of enteral feeding after bedside PEG placement in ventilated Trauma and Surgical ICU patients.
Gender:
All
Ages:
Between 18 years and 100 years
Trial Updated:
10/18/2021
Locations: Carilion Roanoke Memorial Hospital, Roanoke, Virginia
Conditions: Critical Illness, Malnutrition, Gastrostomy, Procedural Sequelae, Trauma, Surgery, Mechanical Ventilation
Register for Updates
Myeloma-Developing Regimens Using Genomics (MyDRUG)
NCT03732703
Recruiting
The MyDRUG study is a type of Precision Medicine trial to treat patients with drugs targeted to affect specific genes that are mutated as part of the disease. Mutations in genes can lead to uncontrolled cell growth and cancer. Patients with a greater than 25% mutation to any of the following genes; CDKN2C, FGFR3, KRAS, NRAS, BRAF V600E, IDH2 or T(11;14) can be enrolled to one of the treatment arms. These arms have treatments specifically directed to the mutated genes. Patients that do not have a... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
09/09/2021
Locations: Virginia Cancer Specialists, Fairfax, Virginia
Conditions: Relapsed Refractory Multiple Myeloma
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Fetal Cardiac Function Parameters and HbA1c as Screening for Gestational Diabetes Mellitus
NCT05019508
Recruiting
This is a prospective cohort study to assess the predictive value of fetal cardiac parameters, the change in fetal cardiac parameters (CFP), HbA1c, and/or the change in HbA1c (ΔHbA1c) for gestational diabetes.
Gender:
Female
Ages:
Between 18 years and 50 years
Trial Updated:
08/18/2021
Locations: University of Virginia, Charlottesville, Virginia
Conditions: Gestational Diabetes
Register for Updates
Prospective US Radiofrequency SUI Trial
NCT04720352
Recruiting
PURSUIT: Prospective US Radiofrequency SUI Trial (VI-17-06) is a prospective, randomized, sham controlled, double blind study in premenopausal women with stress urinary incontinence. The study will be conducted in 390 subjects, randomized 2:1 with active or sham treatment. Study duration is 12 months post treatment. The primary objective is to evaluate the efficacy of the Viveve treatment, SUI protocol, in improving mild to moderate stress urinary incontinence (SUI), assessed using the 1-hour Pa... Read More
Gender:
Female
Ages:
18 years and above
Trial Updated:
07/19/2021
Locations: Health Research of Hampton Roads, Inc, Newport News, Virginia
Conditions: Urinary Incontinence, Stress
Register for Updates