There are currently 126 active clinical trials seeking participants for Dementia research studies. The states with the highest number of trials for Dementia participants are Florida, California, New York and Pennsylvania.
Life's End Benefits of Cannabidiol and Tetrahydrocannabinol
NCT05644262
Recruiting
This is a multicenter randomized double-blind placebo-controlled Phase 2 study of an oral combination of tetrahydrocannabinol (THC) and cannabidiol (CBD) compared to placebo over 12 weeks. This study is designed to test the hypothesis that treatment with an oral combination of THC/CBD will reduce agitation hospice care-eligible patients with agitation and dementia as measured by the Cohen Mansfield Agitation Inventory (CMAI) when compared to placebo at 2 weeks. This study will enroll approximat... Read More
Gender:
All
Ages:
40 years and above
Trial Updated:
05/16/2024
Locations: Sun Valley Research Center, Imperial, California +10 locations
Conditions: Agitation, Dementia
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New IDEAS: Imaging Dementia-Evidence for Amyloid Scanning Study
NCT04426539
Recruiting
New IDEAS is an observational, open-label, longitudinal cohort study designed to address the requirements of the CED provisions of the NCD on beta-amyloid PET. Building on the initial Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) study, New IDEAS will evaluate the association between amyloid PET and patient-centered outcomes in an expanded and more ethnoracially and clinically diverse group of Medicare participants presenting with cognitive impairment.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/15/2024
Locations: Full list of Active Sites and Imaging Facilities, Philadelphia, Pennsylvania
Conditions: Alzheimer's Disease, Dementia, Mild Cognitive Impairment
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5-Cog 2.0: A Pragmatic Clinical Trial
NCT05515224
Recruiting
Cognitive impairment related to dementia is frequently under-diagnosed in primary care settings. This problem is more prevalent in health disparities populations. The investigators developed the 5-Cog brief cognitive assessment that is simple to use, standardized, takes <5 minutes, does not require informants, and accounts for major technical, cultural, and logistical barriers of current assessments. The investigators propose a hybrid Type 1 effectiveness-implementation design in real-world sett... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
05/13/2024
Locations: Indiana University, Bloomington, Indiana +1 locations
Conditions: Dementia, Cognitive Impairment
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Promoting Goals-of-Care Discussions for Patients With Memory Problems and Their Caregivers
NCT05596760
Recruiting
The goal of this clinical trial is to improve communication among clinicians, patients with memory problems, and their family members. We are testing a way to help clinicians have better conversations to address patients' goals for their healthcare. To do this, we created a simple, short guide called the "Jumpstart Guide." The goal of this research study is to show that using this kind of guide is possible and can be helpful for patients and their families. Patients' clinicians may receive a Jum... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/10/2024
Locations: Harborview Medical Center, Seattle, Washington +2 locations
Conditions: Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive, Heart Failure，Congestive, Liver Cirrhosis, Kidney Failure, Chronic, Lung Diseases, Interstitial, Peripheral Vascular Diseases, Diabetes With End Organ Damage, Palliative Care, Patient Care, Health Care Quality, Access, and Evaluation, Patient Care, Health Communication, Patient Care Planning, Quality of Life
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Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001
NCT01760005
Recruiting
The purpose of this study is to assess the safety, tolerability, biomarker, cognitive and clinical efficacy of investigational products in participants with an Alzheimer's disease-causing mutation by determining if treatment with the study drug slows the rate of progression of cognitive/clinical impairment or improves disease-related biomarkers.
Gender:
All
Ages:
Between 18 years and 80 years
Trial Updated:
05/10/2024
Locations: University of Alabama in Birmingham, Birmingham, Alabama +38 locations
Conditions: Alzheimers Disease, Dementia, Alzheimers Disease, Familial
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The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
NCT04171323
Recruiting
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulation (which will serve as a stringent, active control) to modify the functional trajectories of older adults' with MCI, who are at high risk for dementia. The primary objective of the U01 phase was to d... Read More
Gender:
All
Ages:
Between 55 years and 89 years
Trial Updated:
05/09/2024
Locations: University of California San Francisco, San Francisco, California +4 locations
Conditions: Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
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Self-Care for Dementia Caregivers
NCT05309577
Recruiting
The Self-care for Dementia Caregivers Study is a behavioral health intervention that uses digital monitoring tools and motivational health coaching to help caregivers of persons with dementia engage in a regular routine of self-care. Participants wear an apple watch for the objective collection of sleep-wake rhythms. They receive personalized feedback on their sleep-wake rhythms via a new app. Health coaches call participants weekly, for 6 weeks to help participants meet their health/sleep goals... Read More
Gender:
All
Ages:
Between 50 years and 99 years
Trial Updated:
05/09/2024
Locations: University of Pittsburgh, Pittsburgh, Pennsylvania
Conditions: Aging, Mental Disorder, Eating, Healthy, Physical Inactivity, Prodromal Symptoms, Sleep, Alzheimer Disease, Dementia, Circadian Rhythm Disorders
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HEARS-SLP: Providing SLP-Delivered Hearing Health Care to Individuals With Cognitive Impairment
NCT06008782
Recruiting
Building upon the HEARS audiologist-community health worker (CHW) model, this study intervention will be delivered by a speech-language pathologist (SLP). The primary objective of the study is to develop and test an affordable and accessible hearing rehabilitative intervention that will be delivered by a SLP to individuals with cognitive impairment.
Gender:
All
Ages:
Between 60 years and 100 years
Trial Updated:
05/08/2024
Locations: Johns Hopkins Medicine, Baltimore, Maryland
Conditions: Hearing Loss, Dementia, Cognitive Impairment
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Palliative Care for Patients With Dementia
NCT05749146
Recruiting
A multi-site, single-blinded, parallel, randomized-controlled trial to evaluate the effectiveness of a novel model of in-home palliative care for dementia patients and their family caregivers. From inpatient and outpatient settings associated with four hospitals across New York City, patients with advanced dementia and their family caregivers will be randomized to intervention or augmented control.
Gender:
All
Ages:
65 years and above
Trial Updated:
05/08/2024
Locations: Ichan School of Medicine at Mount Sinai, New York, New York
Conditions: Dementia
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Enhancing Triadic Communication About Cognition for Older Adults With Alzheimer's Disease or Related Dementias Facing a Cancer Management Decision
NCT06313853
Recruiting
Building upon prior work, the investigator team developed a communication intervention for older adults with ADRD who are considering a decision about cancer management (adapted intervention: COACH-Cog). The investigators hypothesize that for patients with dual diagnoses of ADRD and cancer, COACH-Cog will increase autonomy support of care partners and patients in the decision-making process, leading to greater acknowledgement and support of cognitive concerns and cognitive-related goals, thereby... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
05/02/2024
Locations: University of Rochester Wilmot Cancer Institute, Rochester, New York
Conditions: Cancer, Dementia
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Enhancing Health and Quality of Life for Individuals With Dementia Through Transitional-State Snacks
NCT05007730
Recruiting
Malnutrition significantly contributes to the disability and mortality associated with Alzheimer's disease and Alzheimer's disease-related dementias. Thus, nutritional status is one important, modifiable clinical factor for maintaining physical and cognitive health among persons with dementia (PWD). This project will pilot an innovative approach to enhancing nutrition through the use of transitional-state snack supplements, or foods that start as one texture and change to another. Specifically,... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
05/01/2024
Locations: University of Oregon, Eugene, Oregon +1 locations
Conditions: Dementia, Nutrition Poor
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Early Cognitive Intervention in Delirium
NCT04740567
Recruiting
This is a randomized control trial to determine if early cognitive training and rehabilitation improve 4-month cognition in hospitalized older (>=65 years old) delirious patients with and without Alzheimer's disease and related dementias. Enrolled patients will be randomized to receive cognitive intervention versus usual care at a 1:2 allocation ratio. Patients assigned to the cognitive intervention group will receive cognitive training daily during hospitalization and cognitive rehabilitation w... Read More
Gender:
All
Ages:
65 years and above
Trial Updated:
04/27/2024
Locations: Tennessee Valley Healthcare System - Nashville Veteran Affairs Hospital, Nashville, Tennessee +1 locations
Conditions: Delirium, Cognitive Decline, Dementia
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