There are currently 106 active clinical trials seeking participants for Dementia research studies. The states with the highest number of trials for Dementia participants are Florida, California, New York and Ontario.
Deprescribing Potentially Inappropriate Medications in the Emergency Department for Persons Living with Dementia
NCT06273917
Recruiting
Aim 1: To demonstrate the feasibility by determining proportion of completed medication reconciliation, Central Nervous System active Potentially Inappropriate Medication (CNS PIM) use among patients with Alzheimer's Disease and Related Dementias (ADRD) and Mild Cognitive Impairment (MCI) in the emergency department (ED), and communication between ED clinical pharmacists and outpatient prescribers. Aim 2: To demonstrate the feasibility of collecting the primary and secondary outcomes for a subs... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
01/23/2025
Locations: Northwestern Memorial Hospital, Chicago, Illinois +2 locations
Conditions: Dementia
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Caregiver as Navigator: Develop Skills Online (CAN-DO)
NCT06177990
Recruiting
This study is designed to learn more about ways to promote caregiver mastery online. 270 dementia family caregivers will be enrolled and randomized to take the CAN-DO online course immediately or after a waiting period. They will participate in interviews before and after the course; total time of study participation is 6 months.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/06/2025
Locations: Emory Roybal Center for Dementia Caregiving Mastery, Atlanta, Georgia
Conditions: Dementia
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The Active Mind Trial: An Adaptive Randomized Trial to Improve Function and Delay Dementia
NCT04171323
Recruiting
Older adults at risk for dementia show a variety of cognitive deficits, which can be ameliorated by different cognitive training (CT) exercises. The best combination of CT exercises is unknown. The aim is to discover the most efficacious combination of CT exercises as compared to cognitive stimulation (which will serve as a stringent, active control) to modify the functional trajectories of older adults' with MCI, who are at high risk for dementia. The primary objective of the U01 phase was to d... Read More
Gender:
ALL
Ages:
Between 55 years and 89 years
Trial Updated:
12/05/2024
Locations: University of California San Francisco, San Francisco, California +3 locations
Conditions: Age-related Cognitive Decline, Mild Cognitive Impairment, Dementia
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ADRC Clinical Cohort (Alzheimer's Disease)
NCT06703541
Recruiting
The purpose of the study is to establish a clinical cohort for the Duke/UNC Alzheimer's Disease Research Center (ADRC). The cohort will be composed of subjects ages 25 to 44 at enrollment with normal cognition and subjects ages 45 to 80 at enrollment with normal cognition, mild cognitive impairment, or a dementia diagnosis. Initial data including demographics, medical and family history, physical exam, and neuropsychological testing will be obtained. Participants will be asked to contribute a bl... Read More
Gender:
ALL
Ages:
Between 25 years and 80 years
Trial Updated:
11/21/2024
Locations: Duke University, Durham, North Carolina
Conditions: Alzheimer Disease, Mild Cognitive Impairment, Dementia
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Evaluating the Efficacy of the Pain Identification and Communication Toolkit
NCT06168604
Recruiting
This study will evaluate the Pain Identification and Communication Toolkit (PICT), a multicomponent intervention for caregivers of people with Alzheimer's disease and related dementias (ADRD). PICT provides training in observational pain assessment and coaching in effective pain communication techniques. It will recruit participants from programs of all-inclusive care for the elderly (PACE) and partnering health care clinics. The investigators hypothesize that PICT will help caregivers to recogn... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/18/2024
Locations: Weill Cornell Medicine, New York, New York
Conditions: Caregiver Burden, Cognitive Impairment, Dementia, Alzheimer Disease, Pain, Chronic
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Dementia and Diabetes Prevention Program
NCT04141878
Recruiting
This is a multicenter, randomized 2-arm clinical trial of two lifestyle interventions varying in intensity and format, in 400 older African American and non-Hispanic whites at increased risk of cognitive decline and dementia in the East San Francisco Bay Area. The trial will include two lifestyle interventions that differ in intensity and format: 1. Aerobic Exercise (AEx) Intervention that involves aerobic activities with in-class walking workouts and tutorials and carried out at the East Oakla... Read More
Gender:
ALL
Ages:
60 years and above
Trial Updated:
11/05/2024
Locations: University of California, Davis Alzheimer's Disease Center, Walnut Creek, California
Conditions: Diabetes, Dementia
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Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium
NCT06052397
Recruiting
The goal of this prospective cohort study is to assess potential differences in sleep biomarkers in older adult patients undergoing major orthopedic surgery. The main questions it aims to answer are: 1. To define sleep/circadian biomarkers of delirium (sleep duration, regularity, stability and timing of rhythm) in a prospective observational study. 2. To determine if plasma Alzheimer's disease (AD) pathology/inflammatory burden interacts with or moderates the relationship between a sleep/circad... Read More
Gender:
ALL
Ages:
70 years and above
Trial Updated:
11/04/2024
Locations: Massachusetts General Hospital, Boston, Massachusetts
Conditions: Delirium, Postoperative, Cognitive Decline, Dementia
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Paradoxical Lucidity in Severe End-Stage Dementia
NCT05234866
Recruiting
Cognitive decline in dementia is considered irreversible, however episodes of paradoxical lucidity (PL) in severe dementia suggest other mechanisms may be in play. Beyond anecdotal reports of transient PL events occurring in patients predominantly in late-stage dementia and typically lasting anywhere from a few minutes to several hours, little is known about PL. The study team proposes to develop and conduct a mixed methods prospective study of PL during end stage advanced dementia, creating a d... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/30/2024
Locations: NYU Langone Health, New York, New York
Conditions: Dementia
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Dementia Care Partner Hospital Assessment Tool
NCT05592366
Recruiting
The purpose of this study is to see whether an adapted questionnaire called the Care Partner Hospital Assessment Tool (CHAT) for care partners of hospitalized patients living with Alzheimer's disease and related dementias (ADRD) (CHAT-AD) can help people with dementia receive better care after they go home from the hospital. Participants will be a care partner ('family member or friend') who provides unpaid care to a hospitalized adult relative or partner to help them take care of themselves bec... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
09/18/2024
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Alzheimer Disease, Dementia
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Palliative Care for Patients with Dementia
NCT05749146
Recruiting
A multi-site, single-blinded, parallel, randomized-controlled trial to evaluate the effectiveness of a novel model of in-home palliative care for dementia patients and their family caregivers. From inpatient and outpatient settings associated with four hospitals across New York City, patients with advanced dementia and their family caregivers will be randomized to intervention or augmented control.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
09/04/2024
Locations: Ichan School of Medicine at Mount Sinai, New York, New York
Conditions: Dementia
Register for Updates
Sleep Enhancement for Older Adults Living With Memory Loss And Their Care Partners
NCT06250725
Recruiting
The purpose of this study is to determine if a 6-week videoconference intervention to teach skills to improve sleep is practical, acceptable, and helpful to persons living with memory loss, cognitive impairment, and/or dementia and care partners, individually or together.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Emory Healthcare System, Atlanta, Georgia
Conditions: Sleep Disturbance, Dementia
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Cognitive Outcomes of Brain Stimulation As a Later-in-Life Treatment
NCT05564715
Recruiting
This is a pilot study being done to attempt to improve episodic memory problems in persons with mild cognitive impairment (MCI) or dementia. The pre-supplemental motor area (preSMA) and dorsal anterior cingulate cortex (dACC) have been shown to play a role in episodic memory and language retrieval. Prior studies have suggested that neurostimulation targeting this region can improve episodic memory and word recall. The purpose of this study is to examine the efficacy of high-definition transcrani... Read More
Gender:
ALL
Ages:
55 years and above
Trial Updated:
08/08/2024
Locations: University of Texas Southwestern Medical Center, Dallas, Texas
Conditions: Mild Cognitive Impairment, Dementia, Amnestic Mild Cognitive Impairment - aMCI
Register for Updates