Maryland is currently home to 2667 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Clinical Trial of Approaches to Prostate Cancer Surgery
Recruiting
This is a prospective, randomized controlled trial to compare cancer control and health-related quality of life following pelvic fascia-sparing radical prostatectomy versus standard radical prostatectomy. The investigators hypothesize that pelvic fascia-sparing radical prostatectomy will have similar cancer control (primary outcome) and sexual function outcomes; and significantly better urinary function, penile shortening/deformity and inguinal hernia risks as compared to radical prostatectomy.
Gender:
MALE
Ages:
Between 40 years and 80 years
Trial Updated:
05/14/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Prostate Cancer
A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM
Recruiting
An observational study to assess real-world patient characteristics and clinical course of disease in participants with PKP2-ACM.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/13/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
Behavioral Pharmacology of Orally Administered THC and D-limonene
Recruiting
The current clinical trial will investigate the effects of orally administered d-limonene (limonene), delta-9-tetrahydrocannabinol (THC) and the combination in healthy adult volunteers.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
05/13/2025
Locations: Johns Hopkins Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Subjective Drug Effects, THC, D-limonene
CAPABLE Transplant
Recruiting
The purpose of this mixed methods study is to adapt CAPABLE as CAPABLE Transplant to accomplish two things: 1) To resolve barriers to being classified as active on the Kidney Transplant (KT) waitlist, 2) as a surgical prehabilitation intervention targeting the pre-frail/ frail KT waitlist population. It consists of two phases- an open label pilot and a randomized waitlist control trial, and 3) pilot test the feasibility and acceptability for CAPABLE Transplant in symptom and waitlist specific me... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Johns Hopkins School of Nursing, Baltimore, Maryland
Conditions: Quality of Life, Depression, End Stage Renal Disease, Disability Physical
Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)
Recruiting
This is a research study to test the safety and effectiveness of using the drug alpelisib together with chemotherapy (nab-paclitaxel) and a drug called L-NMMA in patients with HER2 negative metastatic or locally advanced metaplastic breast cancer, who have not responded to previous treatments. Participants in this study in addition to the standard care chemotherapy will also receive the drug alpelisib and L-NMMA. The therapies will be administered every 3 weeks (1 cycle) until disease progressi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: National Institute of Health Clinical Center, Bethesda, Maryland
Conditions: HER2-negative Breast Cancer, Metastatic Breast Cancer, Metaplastic Breast Carcinoma, TNBC - Triple-Negative Breast Cancer
Systems Biology of Early Atopy
Recruiting
The goal of this study is to establish a birth cohort that collects prenatal and early life biosamples and environmental samples and rigorously phenotypes young children for food allergy and Atopic Dermatitis (AD) to identify prenatal and early life markers of high risk for food allergy and AD, as well as biological pathways (endotypes) that result in these conditions. Primary Objectives: * To study the role and interrelationships of established and novel clinical, environmental, biological, a... Read More
Gender:
ALL
Ages:
0 years and above
Trial Updated:
05/13/2025
Locations: Johns Hopkins Children's Center, Department of Allergy & Immunology, Baltimore, Maryland
Conditions: Allergic Diseases, Food Allergy, Atopic Dermatitis
The HOPE Study: Characterizing Patients With Hepatitis B and C
Recruiting
This is an observational, longitudinal, prospective study for sample collection and evaluation for future therapy or disease progression of chronic hepatitis B and C. Participants will be seen on an annual basis with optional additional visits for up to 10 years and provide samples for research and evaluation of disease progression. In addition, there is a longitudinal sub-study for treatment of hepatitis B that will involve 2 years of treatment with tenofovir alafenamide and blood collections w... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/13/2025
Locations: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Hepatitis B, Chronic, Hepatitis C
Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis
Recruiting
This study aims to study the feasibility of psilocybin therapy for patients with Amyotropic Lateral Sclerosis (ALS) with depressed mood. The secondary objective is to assess its impact on depression, quality of life, hopelessness, and functional status in this patient population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Conditions: Amyotrophic Lateral Sclerosis
Prescreening Study to Identify Potential Stargardt Participants for ACDN-01 Clinical Trials
Recruiting
This is an observational prescreening study. Individuals who are eligible for prescreening will undergo testing procedures that may be used to determine eligibility in ACDN-01 clinical trials.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
05/12/2025
Locations: Wilmer Eye Institute at John Hopkins, Baltimore, Maryland
Conditions: Stargardt Disease, Stargardt Disease 1, Cone Rod Dystrophy, Juvenile Macular Degeneration
A Pilot Study of a Commercially-available Oil Rinse Product (PerioPull™) on Markers of Dental Health
Recruiting
The primary purpose of this study is to evaluate the impact of a commercially-available oil rinse product (PerioPull™) on parameters of dental health among a sample of adults. PerioPull™ is commercially available and sold primarily from clinicians' offices. A 12-week pilot study will be conducted to achieve the purpose of this study. The research team hypothesizes that PerioPull™ will improve a variety of validated markers of dental health that are commonly used in clinical practice.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Julian Center for Comprehensive Dentistry, Ellicott City, Maryland
Conditions: Oral Health
Cerebellar Involvement in Alcohol Use Disorder (AUD)
Recruiting
The goal of this observational and interventional study is to better understand the involvement of the cerebellum in the brain reward system in persons with alcohol use disorder (AUD). The main questions it aims to answer are: 1. What is the nature of cerebellar input to the ventral tegmental area (VTA) in the brain reward system, and how is it perturbed in AUD? 2. What is the relationship between measures of cerebellar integrity and magnitude of reward activation to alcohol-related cues in cer... Read More
Gender:
ALL
Ages:
Between 25 years and 55 years
Trial Updated:
05/12/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Alcohol Use Disorder
Effects of Psilocybin in Obsessive Compulsive Disorder
Recruiting
This study will test the feasibility, safety, and evidence for efficacy of psilocybin administration in participants with obsessive compulsive disorder (OCD). This will serve as a preliminary proof of concept study for future larger studies aimed to investigate the utility, cognitive mechanisms, and neural correlates of this intervention.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
05/12/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Obsessive-Compulsive Disorder