Maryland is currently home to 2668 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
A Study to Assess Real-world Patient Characteristics and Clinical Course for Symptomatic Patients With PKP2-ACM
NCT06976606
Recruiting
An observational study to assess real-world patient characteristics and clinical course of disease in participants with PKP2-ACM.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
05/13/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
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Behavioral Pharmacology of Orally Administered THC and D-limonene
NCT06378957
Recruiting
The current clinical trial will investigate the effects of orally administered d-limonene (limonene), delta-9-tetrahydrocannabinol (THC) and the combination in healthy adult volunteers.
Gender:
ALL
Ages:
Between 21 years and 55 years
Trial Updated:
05/13/2025
Locations: Johns Hopkins Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Subjective Drug Effects, THC, D-limonene
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CAPABLE Transplant
NCT06326905
Recruiting
The purpose of this mixed methods study is to adapt CAPABLE as CAPABLE Transplant to accomplish two things: 1) To resolve barriers to being classified as active on the Kidney Transplant (KT) waitlist, 2) as a surgical prehabilitation intervention targeting the pre-frail/ frail KT waitlist population. It consists of two phases- an open label pilot and a randomized waitlist control trial, and 3) pilot test the feasibility and acceptability for CAPABLE Transplant in symptom and waitlist specific me... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: Johns Hopkins School of Nursing, Baltimore, Maryland
Conditions: Quality of Life, Depression, End Stage Renal Disease, Disability Physical
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Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)
NCT05660083
Recruiting
This is a research study to test the safety and effectiveness of using the drug alpelisib together with chemotherapy (nab-paclitaxel) and a drug called L-NMMA in patients with HER2 negative metastatic or locally advanced metaplastic breast cancer, who have not responded to previous treatments. Participants in this study in addition to the standard care chemotherapy will also receive the drug alpelisib and L-NMMA. The therapies will be administered every 3 weeks (1 cycle) until disease progressi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/13/2025
Locations: National Institute of Health Clinical Center, Bethesda, Maryland
Conditions: HER2-negative Breast Cancer, Metastatic Breast Cancer, Metaplastic Breast Carcinoma, TNBC - Triple-Negative Breast Cancer
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Systems Biology of Early Atopy
NCT04798079
Recruiting
The goal of this study is to establish a birth cohort that collects prenatal and early life biosamples and environmental samples and rigorously phenotypes young children for food allergy and Atopic Dermatitis (AD) to identify prenatal and early life markers of high risk for food allergy and AD, as well as biological pathways (endotypes) that result in these conditions. Primary Objectives: * To study the role and interrelationships of established and novel clinical, environmental, biological, a... Read More
Gender:
ALL
Ages:
0 years and above
Trial Updated:
05/13/2025
Locations: Johns Hopkins Children's Center, Department of Allergy & Immunology, Baltimore, Maryland
Conditions: Allergic Diseases, Food Allergy, Atopic Dermatitis
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The HOPE Study: Characterizing Patients With Hepatitis B and C
NCT02995252
Recruiting
This is an observational, longitudinal, prospective study for sample collection and evaluation for future therapy or disease progression of chronic hepatitis B and C. Participants will be seen on an annual basis with optional additional visits for up to 10 years and provide samples for research and evaluation of disease progression. In addition, there is a longitudinal sub-study for treatment of hepatitis B that will involve 2 years of treatment with tenofovir alafenamide and blood collections w... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
05/13/2025
Locations: Institute of Human Virology, University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Hepatitis B， Chronic, Hepatitis C
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Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosis
NCT06656702
Recruiting
This study aims to study the feasibility of psilocybin therapy for patients with Amyotropic Lateral Sclerosis (ALS) with depressed mood. The secondary objective is to assess its impact on depression, quality of life, hopelessness, and functional status in this patient population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Conditions: Amyotrophic Lateral Sclerosis
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Prescreening Study to Identify Potential Stargardt Participants for ACDN-01 Clinical Trials
NCT06445322
Recruiting
This is an observational prescreening study. Individuals who are eligible for prescreening will undergo testing procedures that may be used to determine eligibility in ACDN-01 clinical trials.
Gender:
ALL
Ages:
5 years and above
Trial Updated:
05/12/2025
Locations: Wilmer Eye Institute at John Hopkins, Baltimore, Maryland
Conditions: Stargardt Disease, Stargardt Disease 1, Cone Rod Dystrophy, Juvenile Macular Degeneration
Register for Updates
A Pilot Study of a Commercially-available Oil Rinse Product (PerioPull™) on Markers of Dental Health
NCT06363721
Recruiting
The primary purpose of this study is to evaluate the impact of a commercially-available oil rinse product (PerioPull™) on parameters of dental health among a sample of adults. PerioPull™ is commercially available and sold primarily from clinicians' offices. A 12-week pilot study will be conducted to achieve the purpose of this study. The research team hypothesizes that PerioPull™ will improve a variety of validated markers of dental health that are commonly used in clinical practice.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/12/2025
Locations: Julian Center for Comprehensive Dentistry, Ellicott City, Maryland
Conditions: Oral Health
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Cerebellar Involvement in Alcohol Use Disorder (AUD)
NCT05732207
Recruiting
The goal of this observational and interventional study is to better understand the involvement of the cerebellum in the brain reward system in persons with alcohol use disorder (AUD). The main questions it aims to answer are: 1. What is the nature of cerebellar input to the ventral tegmental area (VTA) in the brain reward system, and how is it perturbed in AUD? 2. What is the relationship between measures of cerebellar integrity and magnitude of reward activation to alcohol-related cues in cer... Read More
Gender:
ALL
Ages:
Between 25 years and 55 years
Trial Updated:
05/12/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Alcohol Use Disorder
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Effects of Psilocybin in Obsessive Compulsive Disorder
NCT05546658
Recruiting
This study will test the feasibility, safety, and evidence for efficacy of psilocybin administration in participants with obsessive compulsive disorder (OCD). This will serve as a preliminary proof of concept study for future larger studies aimed to investigate the utility, cognitive mechanisms, and neural correlates of this intervention.
Gender:
ALL
Ages:
Between 21 years and 70 years
Trial Updated:
05/12/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Obsessive-Compulsive Disorder
Register for Updates
Innovations in Genicular Outcomes Registry
NCT05495334
Recruiting
The registry will capture prospective data on patients receiving pain management for chronic pain due to knee osteoarthritis (OA) or pain optimization for knee arthroplasty due to knee OA. The OA pain therapies may include cryo nerve block, radiofrequency ablation (RFA), intra-articular (IA) corticosteroids, viscosupplementation, opioids, and others (e.g., non-steroidal anti-inflammatory drugs \[NSAIDs\]).
Gender:
ALL
Ages:
All
Trial Updated:
05/12/2025
Locations: Sinai Hospital of Baltimore, Baltimore, Maryland
Conditions: Knee Osteoarthritis
Register for Updates