Maryland is currently home to 2677 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Dupilumab De-escalation in Pediatric Atopic Dermatitis
NCT06116526
Recruiting
This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD) control on dupilumab.
Gender:
ALL
Ages:
Between 1 year and 17 years
Trial Updated:
01/13/2025
Locations: Johns Hopkins Univerisity, Baltimore, Maryland
Conditions: Atopic Dermatitis
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Developmental Impacts of Microplastics Exposure in Early Life
NCT06107933
Recruiting
The goal of this observational study is to characterize and evaluate micro- and nano-plastic (MNP) exposures among mothers and infants in mother-infant dyads 1 or 3 months postpartum living in Baltimore, Maryland. The main questions it aims to answer are: * What MNPs are present in breastmilk and maternal blood samples and in their infants stool sample? * Are there associations between amount of maternal MNPs in breast milk and mass of MNP particles in infant stool? * Which environmental and li... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: East Baltimore Pediatric Inpatient and Outpatient Clinical Research Unit, Baltimore, Maryland
Conditions: Infant Development, Breast Feeding, Environmental Exposure
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A Phase 2b, Randomized, Double-blind Study of Redasemtide (S-005151) in Adult Participants With Acute Ischemic Stroke
NCT05953480
Recruiting
The purpose of this study is to evaluate the efficacy and safety of redasemtide in adult participants with acute ischemic stroke (AIS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: Sinai Hospital of Baltimore, Baltimore, Maryland
Conditions: Acute Ischemic Stroke
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Improving Pediatrician Counseling About Infant Safe Sleep Using the Electronic Medical Record
NCT05503771
Recruiting
The study team will evaluate the impact of an Infant Sleep Assessment (ISA) tool with motivational interviewing (MI) communication training on clinician-parent communication during 2-month Well Baby Visits (WBV) and parent reported and observed infant sleep practices. The study team's hypotheses are that 1) clinicians who utilize the ISA with MI training will more effectively communicate safe sleep information to their patients' parents, and 2) these parents will have safer infant sleep practice... Read More
Gender:
ALL
Ages:
Between 3 days and 75 years
Trial Updated:
01/13/2025
Locations: Harriet Lane Clinic, Baltimore, Maryland
Conditions: Sudden Infant Death, Sudden Unexplained Infant Death
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A Comparison of Two Brief Suicide Prevention Interventions Tailored for Youth on the Autism Spectrum
NCT05398250
Recruiting
Rates of suicide have increased significantly over the past two decades, particularly among youth. Compared to the general population, autistic people are significantly more likely to think about suicide, attempt suicide, and die by suicide. Autistic individuals have identified suicide prevention as a top research priority; however, little is known about how to best help autistic youth at risk for suicide. The purpose of this study is to compare the effectiveness, feasibility, and acceptability... Read More
Gender:
ALL
Ages:
Between 12 years and 99 years
Trial Updated:
01/13/2025
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Suicidal Ideation, Suicidal and Self-injurious Behavior, Suicide, Autism Spectrum Disorder
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ProAgio in Previously Treated Advanced Pancreatic Cancer and Other Solid Tumor Malignancies
NCT05085548
Recruiting
The study is a first-in-human, Phase I study to assess the safety of ProAgio in participants with advanced solid tumor malignancies including pancreatic cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: National Cancer Institute, Bethesda, Maryland
Conditions: Advanced Pancreatic Cancer, Solid Tumor Malignancies
Register for Updates
Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients
NCT04217551
Recruiting
A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
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NBTXR3 Activated by Radiotherapy for Patients with Advanced Cancers Treated with an Anti-PD-1 Therapy
NCT03589339
Recruiting
The 1100 study is an open-label, Phase I, dose escalation and expansion prospective clinical study to assess the safety of intratumoral injection of NBTXR3 activated by radiotherapy in combination with anti-PD-1 therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/13/2025
Locations: Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Conditions: Radiotherapy, Immunotherapy, Microsatellite Instability-High Solid Malignant Tumour, Squamous Cell Carcinoma of Head and Neck, Metastasis From Malignant Tumor of Cervix, Metastasis From Malignant Melanoma of Skin (Disorder), Metastasis From Malignant Tumor of Bladder (Disorder), Metastasis From Malignant Tumor of Liver, Metastatic Renal Cell Carcinoma, Metastatic Triple-Negative Breast Carcinoma, Metastatic NSCLC
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Study of Vorasidenib and Pembrolizumab Combination in Recurrent or Progressive IDH-1 Mutant Glioma
NCT05484622
Recruiting
Vorasidenib in combination with pembrolizumab in participants with recurrent or progressive isocitrate dehydrogenase-1 (IDH-1) mutant Glioma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/12/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Astrocytoma, Oligodendroglioma
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Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM
NCT06081894
Recruiting
This clinical trial will study the effects of aficamten (versus placebo) on the quality of life, exercise capacity, and clinical outcomes of patients with non-obstructive hypertrophic cardiomyopathy.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
01/11/2025
Locations: MedStar Union Memorial Hospital, Baltimore, Maryland
Conditions: Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy
Register for Updates
Continuous Glucose Monitoring Devices in Hospitalized Veterans With Diabetes
NCT03508934
Recruiting
More than 25% of the patients admitted in the general wards have a history of Diabetes Mellitus (DM). Up to 30% of the hospitalized diabetics develop hypoglycemia (low glucose values); a condition that is associated with seizures, cardiac arrhythmias, and even death. In Veterans, the prevalence is disproportionally higher. It is estimated that 40-50% of hospitalized Veterans are diabetics. In this clinical trial the investigators describe the development of a novel system, the Glucose Telemetry... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
01/10/2025
Locations: Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore, Maryland
Conditions: Diabetes Mellitus, Type 2, Hypoglycemia
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Left Ventricular Structural Predictors of Sudden Cardiac Death
NCT01076660
Recruiting
Sudden cardiac death (SCD) poses a significant health care challenge with high annual incidence and low survival rates. Implantable cardioverter defibrillators (ICDs) prevent SCD in patients with poor heart function. However, the critical survival benefit afforded by the devices is accompanied by short and long-term complications and a high economic burden. Moreover, in using current practice guidelines of reduced heart function, specifically left ventricular ejection fraction (LVEF)≤35%, as the... Read More
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
01/10/2025
Locations: Johns Hopkins Medical Institutions, Baltimore, Maryland
Conditions: Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy
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