Maryland is currently home to 2681 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Brain Volume and Cardiac Function in Heart Failure
NCT06623344
Recruiting
Patients with heart failure (HF) exhibit greater structural brain alterations and higher dementia risks than the general population. Neural atrophy in nearly every region of medical limbic circuit has been observed in HF patients. Reduction of cerebral blood flow has been suggested as the pathophysiological pathway linking HF and structural brain changes. Indeed, lower cardiac index levels were related to lower cerebral blood flow in older adults without stroke, dementia, or heart failure. A few... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
12/10/2024
Locations: Johns Hopkins Center for Advanced Imaging and Research Science, Johns Hopkins Science + Technology Park at 1812 Ashland Avenue, Baltimore, MD, Baltimore, Maryland
Conditions: Heart Failure
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Parenting for Tomorrow: A New Model for Supporting Preschool Children's Mental Health in Head Start
NCT06145477
Recruiting
Purpose of this study is to test the preliminary efficacy, acceptability, accessibility, cost, and sustainability of an innovative mental health treatment model for young children from low-income, under-resourced communities through a partnership with Head Start programs in urban and rural communities in Maryland.
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
12/10/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Parenting, Parenting Intervention
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Sickle Cell Children's Exercise Study (SuCCESs)
NCT06074198
Recruiting
The Sickle Cell Children's Exercise Study (SuCCESs) will explore the feasibility and effects of a moderate intensity strengthening, balance, speed, and agility intervention program in children with sickle cell disease.
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
12/10/2024
Locations: University of Maryland School of Medicine Dept. of Physical Therapy & Rehabilitation Science, Baltimore, Maryland
Conditions: Sickle Cell Disease
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Natural History of Inflammatory Muscle Diseases
NCT05738824
Recruiting
Objective: To collect information and biospecimens (such as blood, muscle, and skin samples) that will be used to research causes and treatments of inflammatory muscle diseases. Eligibility: People aged 12 years and older with suspected or confirmed inflammatory muscle disease. Healthy volunteers aged 18 years and older are also needed. Design: Participants will have at least 1 clinic visit. Each visit will last 4 to 8 hours. Some may return for additional visits. All participants will und... Read More
Gender:
ALL
Ages:
Between 12 years and 120 years
Trial Updated:
12/10/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Inflammation In Skeletal Muscle
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Renal Retention in High Grade Upper Tract Urothelial Cancer
NCT05656235
Recruiting
This trial will evaluate the use of combination pembrolizumab and enfortumab vedotin for patients with high grade non-metastatic (cN0/NxMx, no measurable regional lymph nodes, no metastases) upper tract urothelial cancer (UTUC), preferring to forego standard of care radical nephroureterectomy (RNU) surgery. Currently these patients would not be suitable candidates for neoadjuvant trials, as the patients intention is to forego surgery. The patients are also not candidates for metastatic trials, a... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2024
Locations: Johns Hopkins University: Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Conditions: High Grade Urothelial Carcinoma, Bladder Cancer, Urothelial Carcinoma Bladder
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Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy
NCT05615844
Recruiting
The Beads vs Vac trial is a multi-centre randomized controlled trial of 312 participants with a severe open tibia fracture requiring multiple irrigation and debridement surgeries. Eligible participants will be randomized to receive either an antibiotic bead pouch or negative pressure wound therapy (NPWT) for their temporary open fracture wound management. Outcomes will be assessed at 6 weeks, 3 months, and 6 months post-surgery. The primary outcome will be a composite outcome to evaluate clinica... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/10/2024
Locations: University of Maryland, R Adams Cowley Shock Trauma Center, Baltimore, Maryland
Conditions: Open tíbia Fracture
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Screening for Atrial Fibrillation in Elderly Women Older Than 70 Years
NCT05444335
Recruiting
Screening for Atrial Fibrillation in Elderly Women (SAFE-W) is a pilot study evaluating the prevalence of atrial fibrillation (Afib) in a rapidly aging segment of the population. Studies have shown that women with Afib are more likely to be symptomatic, have increased mortality from stroke resulting from Afib, and are less likely to receive treatment for Afib. University of Maryland Department of Neurology and Vascular Neurology are recruiting women older than 70 years of age to participate in t... Read More
Gender:
FEMALE
Ages:
Between 70 years and 100 years
Trial Updated:
12/10/2024
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Atrial Fibrillation New Onset
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Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects with GlioBlastoma Brain Tumors
NCT05383872
Recruiting
The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type 2.0/2.1 for liquid biopsy in subjects with suspected Glioblastoma brain tumors
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
12/10/2024
Locations: University of Maryland, Baltimore & The University of Maryland Medical System, Baltimore, Maryland
Conditions: Glioblastoma, Glioma, Liquid Biopsy
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A Single-Arm Pilot Trial for Mitigating Relapse of Severe Problem Behavior
NCT06732219
Recruiting
The goal of this study is to improve how we teach self-control and communication skills to children and adolescents with challenging behaviors. Researchers aim to find ways to make behavior-change treatments more effective and long-lasting, even when the environment or reinforcement schedules change. The main questions this study will answer are: Can innovative techniques help children maintain learned skills, such as asking for attention or waiting for rewards, when faced with new people, pla... Read More
Gender:
ALL
Ages:
Between 6 years and 17 years
Trial Updated:
12/09/2024
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Challenging Behavior
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CORE-COMPARE Pilot Study
NCT06170541
Recruiting
The utility of Ultra High-Resolution Computed Tomography (UHR-CT) compared to conventional CT in all-comers (i.e., a generally lower-risk population) remains uncertain but is an important area of study in order to justify wider spread implementation and use of this technology, particularly in light of reports of significantly higher radiation exposure with UHR-CT, as well as longer scan times. The availability of technology to reconstruct conventional resolution (CR) simulation images from the r... Read More
Gender:
ALL
Ages:
Between 21 years and 85 years
Trial Updated:
12/09/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Coronary Heart Disease (CHD)
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A Phase 2b, Study Evaluating Miricorilant in Adult Patients With Nonalcoholic Steatohepatitis/Metabolic Dysfunction-Associated Steatohepatitis (MONARCH)
NCT06108219
Recruiting
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of Miricorilant in Adult Patients with Nonalcoholic Steatohepatitis (MONARCH)
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/09/2024
Locations: Site #440, Rockville, Maryland
Conditions: Nonalcoholic Steatohepatitis (NASH), Metabolic Dysfunction-associated Steatohepatitis (MASH)
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Developing a Support Application for Food Pantries (SAFPAS) to Improve Client Access to Healthy Foods & Enhance Emergency Preparedness
NCT05880004
Recruiting
Food pantries face many challenges, including recruitment and training of staff/volunteers, communications with staff/volunteers and clients, providing client choice, and emergency preparedness. The investigators will develop, implement, and evaluate the Support Application for Food Pantries (SAFPAS), a mobile application to address these concerns under normal and emergency operations, and assess its impact on 20 Baltimore food pantries, and on the healthiness of foods received by 360 food pantr... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/09/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Improving Healthy Food Access in Food Insecurity Populations in Normal and Emergency Situations
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