Maryland is currently home to 2668 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Uncovering Genes Behind Cartilage Tumors and Vascular Anomalies Using Genomic Sequencing
NCT06749366
Recruiting
Background: Ollier disease (OD) and Maffucci syndrome (MS) are rare disorders that increase the risk of cancers in cartilage tissue. These tumors can lead to severe skeletal deformities beginning in childhood. People with OD or MS are also at an increased risk of blood vessel disorders and specific cancers. Researchers want to learn more about what causes these disorders. Objective: To understand the genetic causes of OD and MS. Eligibility: People aged 2 years and older who have OD or MS w... Read More
Gender:
ALL
Ages:
Between 2 years and 100 years
Trial Updated:
04/09/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Enchondromatosis
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A Dose Escalation and Expansion Study of GIGA-564 in Participants With Locally Advanced or Metastatic Solid Tumor Malignancies
NCT06258304
Recruiting
The purpose of this study is to assess the safety and tolerability of GIGA-564 and identify the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) level(s) of GIGA-564 in participants with metastatic or locally advanced solid tumor malignancies.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: National Cancer Institute, Bethesda, Maryland
Conditions: Advanced or Metastatic Solid Tumor Malignancies
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A Phase 2 Study of EIK1001 in Combo With Pembrolizumab and Chemotherapy in Patients With Stage 4 NSCLC
NCT06246110
Recruiting
This study is for patients with advanced/metastatic non-small cells lung cancer (NSCLC) who have not received any treatment through the vein for the advanced disease.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Medstar Franklin Square Cancer Center at Loch Raven Campus, Baltimore, Maryland
Conditions: NSCLC
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mPATH for Low-income Older Adults
NCT05935241
Recruiting
Although empirical research suggests that physical activity interventions benefit cognition and sleep in older adults in general, the possible benefit of physical activity is understudied in low-income older adults. The study aims to test the immediate and sustaining efficacy of an mHealth-facilitated Physical Activity Toward Health (mPATH) intervention on cognitive function and sleep in low-income older adults.
Gender:
ALL
Ages:
65 years and above
Trial Updated:
04/09/2025
Locations: The Johns Hopkins University, School of Nursing, Baltimore, Maryland
Conditions: Sedentary Time, Insomnia, Cognitive Decline
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Dinner Time for Obesity and Prediabetes
NCT05745441
Recruiting
Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity. Specifically, late eating is associated with greater weight gain and metabolic syndrome. However, the mechanism by which late eating harms metabolism is not fully understood but may be related to mis-timing of food intake in relation to the body's endogenous circadian rhythm. Conversely, harmonization of eating timing... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
04/09/2025
Locations: Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Conditions: PreDiabetes, Obesity, Healthy
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FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study
NCT05639543
Recruiting
The purpose of this trial is to assess dose related safety, efficacy, and pharmacokinetics (PK) of INT-787 in participants with severe alcohol-associated hepatitis (sAH).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
04/09/2025
Locations: Mercy Medical Center, Baltimore, Maryland
Conditions: Alcohol Associated Hepatitis
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1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV
NCT05608421
Recruiting
This study tests a 5-session cognitive behavioral approach program (herein referred to as the 1MoreStep intervention) to train Black women living with HIV (BWLWHI) and exposed to intimate partner violence (IPV) in the past 2 years (hereafter, BWLWHI) in: 1) cognitive and behavioral skills to access internal and external sources of strength (e.g. self-reliance, safety net); safety strategies, knowledge about Undetectable = Untransmissible (U=U) and HIV care; and reduce internalized and anticipate... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
04/09/2025
Locations: Johns Hopkins School of Nursing, Baltimore, Maryland
Conditions: Violence, Domestic, HIV, Stigma, Social, Engagement, Patient, Medication Adherence
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Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors
NCT00785525
Recruiting
The purpose of the study is to: * Establish and evaluate a system for collection of filgrastim-mobilized peripheral blood stem cells from National Marrow Donor Program donors (NMDP) donors * Assess the safety among NMDP donors of filgrastim administration and PBSC leukapheresis * Assess the safety and efficacy of filgrastim-mobilized PBSC in unrelated donor hematopoietic stem cell transplant recipients * Determine the acceptability of stem cell donation by filgrastim stimulated apheresis in nor... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
04/09/2025
Locations: C.W. Bill Young Marrow Donor Center, Rockville, Maryland
Conditions: Healthy
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Predictors of Pregnancy Outcome in Systemic Lupus Erythematosus (SLE) and Antiphospholipid Syndrome (APS)
NCT00198068
Recruiting
The PROMISSE Study is an observational study of 700 pregnant patients, enrolled at nine major clinical centers. The purpose of the study is 1) to determine whether certain proteins (called complement split products) that can injure healthy organs can be used to predict poor pregnancy outcome in patients with systemic lupus erythematosus (SLE) and anti-phospholipid syndrome (APS), and/or 2) to determine whether elevated levels of circulating antiangiogenic factors predict pregnancy complications... Read More
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
04/09/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Systemic Lupus Erythematosus, Antiphospholipid Syndrome
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Telerehabilitation for Patients With Chronic Low Back Pain (TeleBACK Clinical Trial)
NCT06821607
Recruiting
The investigators will conduct a prospective, randomized, clinical trial addressing key questions to understanding the effectiveness of telerehabilitation (physical therapy delivered via video-visits) and in-clinic physical therapy for patients with chronic low back pain (LBP). The investigators also seek to understand how patients engage with both care options and how these treatment options influence other LBP-related healthcare utilization. The investigators will explore implementation outco... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
04/08/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Chronic Low Back Pain
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Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment
NCT05948930
Recruiting
The prevalence of dementia will double in the next three decades in the U.S.; effective treatment or prevention for dementia is urgently needed. The current exploratory project aims to evaluate and understand how the brain and cognition may improve after a 12-week intervention that combines brain training and aerobic exercise training to improve brain function, both in those with mild cognitive impairment (some with possible prodromal Alzheimer's disease) and with healthy aging. Findings from th... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
04/08/2025
Locations: University of Maryland Baltimore, Baltimore, Maryland
Conditions: Mild Cognitive Impairment
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A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome
NCT05804669
Recruiting
A Phase 1b/2a, first-in-disease, open-label, multiple-ascending dose exploratory study to evaluate safety, tolerability, pharmacokinetics (PK), and pharmacodynamic biomarker responses associated with CRN04894 (an adrenocorticotropic hormone \[ACTH\] receptor antagonist) in participants with ACTH-dependent Cushing's syndrome (Cushing's disease or Ectopic ACTH Syndrome \[EAS\])
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/08/2025
Locations: National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Bethesda, Maryland
Conditions: Cushing Syndrome, Cushing Disease, Ectopic ACTH Syndrome
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