Maryland is currently home to 2686 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Pharmacologic Induction of Tolerance for Hypoxia & Hypothermia
NCT06129825
Recruiting
Warfighter Performance Optimization in Extreme Environments remains an area of important and intense investigation, with the following goals: (1) Optimize, sustain and augment medical readiness and physiological/ psychological performance in extreme and hazardous military operational environments and (2) develop joint DoD countermeasures and guidance to sustain performance, assess physiological status, and reduce injury risk in extreme and hazardous operational environments. Successful and safe... Read More
Gender:
ALL
Ages:
Between 18 years and 88 years
Trial Updated:
01/23/2025
Locations: University of Maryland Baltimore, Baltimore, Maryland
Conditions: Hypothermia, Hypoxia, Mountain Sickness
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Optilume PoST AppRoval Clinical Evaluation of Andrology ParaMeters
NCT05383274
Recruiting
Single-arm, prospective study assessing semen quality after treatment with the Optilume Urethral DCB in men between 22 and 65 years of age.
Gender:
MALE
Ages:
Between 22 years and 65 years
Trial Updated:
01/23/2025
Locations: Chesapeake, Hanover, Maryland
Conditions: Urethral Stricture
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ZEN003694 and Enzalutamide Versus Enzalutamide Monotherapy in Metastatic Castration-Resistant Prostate Cancer
NCT04986423
Recruiting
This is an open-label, randomized, Phase 2b study of ZEN003694 in combination with enzalutamide vs. enzalutamide monotherapy in patients with mCRPC who have progressed on prior abiraterone by PCWG3 criteria. Disease must have progressed on only abiraterone by PCWG3 criteria prior to study entry. The patient population will be separated into two cohorts: Cohort A: Patients with poor response to prior abiraterone defined as: * Abiraterone started in hormone-sensitive prostate cancer (HSPC) dise... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
01/23/2025
Locations: Maryland Oncology Hematology, P.A., Columbia, Maryland
Conditions: Metastatic Castration-Resistant Prostate Cancer
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Gene Therapy for ACM Due to a PKP2 Pathogenic Variant
NCT06109181
Recruiting
This is a Phase 1/2, first-in-human, open-label, intravenous, dose-escalating, multicenter trial that is designed to assess the safety and tolerability of LX2020 in adult patients with PKP2-ACM
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
01/22/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
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Feasibility and Effectiveness of a Remote Monitoring Program for the Treatment of Diabetic Foot Ulcers
NCT05579743
Recruiting
This research is being done to compare two different methods of wound monitoring for chronic wounds: remote wound monitoring using a smartphone app and in-person wound monitoring in a clinic setting. This will be a pilot non-blinded randomized controlled feasibility trial. The investigators will enroll 120 patients with an active diabetic foot ulcer (DFU) who present to the multidisciplinary diabetic foot clinic in Baltimore, Maryland. Patients will be computer randomized 1:1 to receive wound ca... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Diabetic Foot, Diabetic Foot Ulcer, Wound; Foot, Wound Leg, Wound Heal, Diabetes Complications
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Artemis Proximal Femoral Nail for Internal Fixation of Intertrochanteric Femur Fractures
NCT05559736
Recruiting
In February 2021, Altior Trauma Innovations™ announced that it had received 501(k) FDA approval for the Artemis Proximal Femoral Nail (PFN) System for internal fixation of intertrochanteric femur fractures. The objective of this pilot study is to evaluate safety, efficacy and feasibility of the Artemis PFN implant for operative fixation of intertrochanteric femoral fractures, compared to matched historical control patients who received other implants.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: Johns Hopkins Bayview Medical Center, Baltimore, Maryland
Conditions: Intertrochanteric Fractures, Femoral Fracture, Femoral Neck Fractures
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An Evaluation of Two PTSD Assessments in an Active Duty and Military Veteran Sample
NCT04180930
Recruiting
Given the high prevalence of post-traumatic stress disorder (PTSD) in veterans and active duty military, the focus of this research study is to test the reliability of two new PTSD assessments, the Clinician Administered PTSD Scale for DSM-5 (CAPS-5) and the PTSD Symptom Scale Interview for DSM-5 (PSSI-5) and compare the results between the two new assessments and the previous "gold standard", the Clinician Administered PTSD Scale for DSM-IV (CAPS-IV). Biomarkers believed to be related to PTSD (... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/22/2025
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Stress Disorders, Post-Traumatic
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The CREST-2 Registry
NCT02240862
Recruiting
The objective of C2R is to promote the rapid initiation and completion of enrollment in the CREST-2 randomized clinical trial (clinicaltrials.gov ID NCT02089217). Patients with severe symptomatic and asymptomatic carotid artery occlusive disease will be treated with carotid artery stenting (CAS) performed by experienced and skilled interventionists. Interventionists' eligibility will be determined by a multi-specialty Interventional Management Committee (IMC). Patient eligibility will include pa... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
01/22/2025
Locations: University of Maryland - Administrative Center, Baltimore, Maryland
Conditions: Carotid Artery Diseases
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Rapid Drug Desensitization Study in Adults Experiencing Hypersensitivity Reactions to Palynziq
NCT06780332
Recruiting
The purpose of this study is to determine if rapid drug desensitization (RDD) to Palynziq will improve drug tolerability and treatment persistence in adult patients on commercial Palynziq experiencing hypersensitivity reactions (HSRs) leading to treatment interruption or reduction of dose or dosing frequency. See Section 10.8 for full list of HSR preferred terms. Study details include: * Study duration: Up to 30 weeks (up to 6 weeks for Screening, then RDD, and 24 weeks of follow-up) * RDD dura... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/21/2025
Locations: Uncommon Cures, Chevy Chase, Maryland
Conditions: Phenylketonuria, PKU
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A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)
NCT06548100
Recruiting
This study is researching an experimental drug called mibavademab. The study is focused on participants with GLD who have been on metreleptin treatment for at least 6 months with no change in dose for the last 3 months. The aim of the study is to see how safe and tolerable mibavademab is when switching from treatment with metreleptin. The study is looking at several other research questions, including: * What side effects may happen from taking mibavademab * How much mibavademab is in the blo... Read More
Gender:
ALL
Ages:
2 years and above
Trial Updated:
01/21/2025
Locations: National Institutes of Health, Bethesda, Maryland
Conditions: Generalized Lipodystrophy
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Vallomix Socket Preservation Study
NCT06472453
Recruiting
This research aims to compare the effectiveness of two bone grafting materials on preserving jawbone integrity after tooth extraction. Following extraction, the jawbone surrounding the removed tooth can shrink, affecting future implant placement. By placing a bone graft material in the extraction socket, we aim to maintain adequate jawbone space for future implants. This study compares how well the mixture of vallos®f (human source bone) and Bio-Oss (animal source bone) \[test\], and vallos® onl... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/21/2025
Locations: University of Maryland School of Dentistry, Baltimore, Maryland
Conditions: Alveolar Ridge Augmentation
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Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
NCT06299436
Recruiting
Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this propo... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
01/21/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Heart Failure With Reduced Ejection Fraction, Pulmonary Hypertension, Right Heart Failure Due to Left Heart Failure
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