Maryland is currently home to 2693 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Vascular Disease Discovery Protocol
NCT03538639
Recruiting
Background: Some genetic diseases put increase the risk of heart and blood diseases, which are the number one cause of death and disability in the U.S. Researchers want to study diseases of the heart and/or blood vessels. They want to collect data and specimens from affected people, their family members, and healthy people. Objective: To study diseases of the heart and/or blood vessels. Eligibility: People age 2 and older who may have genetic disease affecting the heart and/or blood vessels... Read More
Gender:
ALL
Ages:
Between 2 years and 100 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Vascular Dysfunction, Genetic Mutations, Genetic Predisposition
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Characterization and Treatment of Adolescent Depression
NCT03388606
Recruiting
This research study seeks to find causes and treatments of depression in teenagers. The study goals are to increase our knowledge of treatments for depression and understand how the brain changes when teenagers have depression. The study will also compare teenagers with depression to those without mental health diagnoses. This outpatient study is recruiting participants ages 11-17 who are depressed. They must have a pediatrician or other medical provider, be medically healthy, and able to perfo... Read More
Gender:
ALL
Ages:
Between 11 years and 25 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
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Taste Bud-Derived Stem Cells in Humans
NCT03366168
Recruiting
Background: Stem cells are found in body tissues. They can regenerate into more of the same cells or become other types of cell. Researchers want to use stem cells from taste buds to try to make cells that secrete insulin. Taste buds are found mostly on the tip and sides of the tongue. Researchers also want to study if the number of taste buds and stem cells decrease as people age. They will remove small pieces of tongue tissue (about the size of a pen tip). The taste buds will grow back. It is... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
06/14/2025
Locations: National Institute of Aging, Clinical Research Unit, Baltimore, Maryland
Conditions: Diabetes
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Nicotinic Receptor Genetic Variation and Alcohol Reward
NCT03294460
Recruiting
Background: People with the brain disease AUD (alcohol use disorder) have a serious problem with drinking. Researchers want to study how different people react to alcohol, and how genes affect this. They will focus on a nicotine receptor gene that may increase a person s AUD risk. Objectives: To see if people with variations of a nicotine receptor gene take alcohol differently and have different brain responses to alcohol cues. Eligibility: Healthy adults ages 21 - 60. This study includes s... Read More
Gender:
ALL
Ages:
Between 21 years and 60 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Alcohol Drinking
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Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (ViPOR) in Relapsed/Refractory B-cell Lymphoma
NCT03223610
Recruiting
Background: B-cell lymphoma is a cancer of white blood cells found in the lymph nodes. It affects the system that fights infections and disease. Researchers want to learn how certain drugs work together to treat B-cell lymphomas. The drugs are venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide (ViPOR). Objective: To study the safety of ViPOR for people with B-cell lymphoma. Eligibility: People ages 18 and older with B-cell lymphoma whose cancer has returned or not improved af... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Lymphoma, Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma, Burkitt Lymphoma
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Administering Peripheral Blood Lymphocytes Transduced With a CD70-Binding Chimeric Antigen Receptor to People With CD70 Expressing Cancers
NCT02830724
Recruiting
Background: In a new cancer therapy, researchers take a person s blood, select a certain white blood cell to grow in the lab, and then change the genes of these cells using a virus. The cells are then given back to the person. This is called gene transfer. For this study, researchers will modify the person s white blood cells with anti-CD70. Objectives: To see if a gene transfer with anti-CD70 cells can safely shrink tumors and to be certain the treatment is safe. Eligibility: Adults age 18... Read More
Gender:
ALL
Ages:
Between 18 years and 72 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Pancreatic Cancer, Renal Cell Cancer, Breast Cancer, Melanoma, Ovarian Cancer
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Pediatric Patients With Metabolic or Other Genetic Disorders
NCT02769949
Recruiting
Background: Some patients with unusual genetic conditions are referred to the National Institutes of Health (NIH). They may not be eligible to join current research studies. Testing such patients is a good way to improve the skills of research staff. The findings could lead to new processes and research. Objectives: To recruit a diverse group of pediatric subjects with genetic disorders. To give clinic staff hands-on experience working with these patients. Eligibility: Children any age with... Read More
Gender:
ALL
Ages:
Between 1 year and 99 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Genetic Disorder, Asperger Disorder, Autism Spectrum Disorder, Fragile X Syndrome, Developmental Delay
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Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge
NCT02639299
Recruiting
Background: Malaria is a serious infection caused by a parasite. People get malaria when an infected mosquito bites them. Malaria can cause major health and social problems in places were malaria is common, such as Africa but can also affect travelers who have never been exposed to malaria. Researchers at the NIH want to find a safe and effective malaria vaccine, antimalarial drugs, or prevention regimen. To do this, healthy volunteers are recruited under a general screening study in order to s... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Malaria
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Rod and Cone Mediated Function in Retinal Disease
NCT02617966
Recruiting
Background: Retinal diseases cause the loss of rod and cone photoreceptors. Symptoms include vision loss and night blindness. Researchers want to learn about rod and cone function in healthy people and people with retinal disease. They want to know if how well a person sees in the dark can test the severity of retinal disease. Objectives: To find out if how well a person sees in the dark can test the severity of retinal disease. To find out if this can help detect retinal disease and track it... Read More
Gender:
ALL
Ages:
Between 5 years and 100 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Retinal Degeneration, Retinitis Pigmentosa, Stargardt's Disease
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Genomic Services Research Program
NCT02595957
Recruiting
Background: Genes are the instructions a person s body uses to function. Genome sequencing is a new way to look at genes that your main research team is using to learn the causes of the condition they are studying. When a new cause is found this way, it is called a primary variant. Each person has many variants. Most do not cause disease. Sequencing can also find secondary variants. These are not related to the condition your main research team is studying, but may show a person to be at high r... Read More
Gender:
ALL
Ages:
Between 1 month and 105 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Colon Cancer, Breast Cancer
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Psychological Treatments for Youth With Severe Irritability.
NCT02531893
Recruiting
Background: When children have severe irritability and temper outbursts, they can be so cranky or angry that it leads to problems at home, in school, and with friends. This is called Disruptive Mood Dysregulation Disorder (DMDD) and there have been no psychological treatments developed specifically for children with this problem. Researchers think two forms of therapy, Cognitive Behavioral Therapy (CBT) and Interpretation Bias Training (IBT), might help children with DMDD. Objective: To test... Read More
Gender:
ALL
Ages:
Between 8 years and 17 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Irritability
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Natural History and Genetics of Food Allergy and Related Conditions
NCT02504853
Recruiting
Background: - About 15 million Americans have a food allergy. Because there are no cures or effective prevention or treatment for food allergies, researchers want to learn more about them. Objective: - To learn more about the causes and effects of food allergy and related conditions. Eligibility: * People ages 2 99 who have food allergy and/or a related genetic or other condition * Their relatives * Healthy relatives and volunteers Design: * Participants will have at least 3 visits over 1... Read More
Gender:
ALL
Ages:
Between 1 day and 99 years
Trial Updated:
06/14/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Food Allergy, Loeys-Dietz Syndrome, Atopic Dermatitis, Eosinophilic Esophagitis
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