Maryland is currently home to 2668 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Study of CTDNA Response Adaptive Immuno-Chemotherapy in NSCLC
NCT04093167
Recruiting
BR36 will evaluate the potential clinical benefit of tailoring immunotherapy treatment based on ctDNA molecular response in non-small cell lung cancer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/14/2025
Locations: The Sidney Kimmel Comprehensive Cancer Centre, Baltimore, Maryland
Conditions: Non-Small Cell Lung Cancer
Register for Updates
The LD Lync Study - Natural History Study of Lipodystrophy Syndromes
NCT03087253
Recruiting
Genetic lipodystrophy syndromes are extremely rare, orphan diseases with overall estimated prevalence of less than 2,000 in the United States. These rare disorders characterized by selective loss of adipose tissue and predisposition to insulin resistance and its metabolic complications diabetes, dyslipidemia and hepatic steatosis. Due to these metabolic problems, atherosclerotic vascular disease, recurrent episodes of acute pancreatitis, cirrhosis and other morbidities complicate the lives of th... Read More
Gender:
ALL
Ages:
All
Trial Updated:
02/14/2025
Locations: National Institutes of Health, Bethesda, Maryland
Conditions: Lipodystrophy (Genetic or Acquired, Non HIV)
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Transnasal Induction of Normothermia for Neurogenic Fever
NCT06038513
Recruiting
The objective of this study is to evaluate the efficacy of the COOLSTAT® Transnasal Thermal Regulating Device in reducing temperature in a population of febrile subjects who meet the inclusion/exclusion criteria.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
02/12/2025
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Stroke, Ischemic, Stroke Hemorrhagic, Seizures, Metabolic Encephalopathy
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Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy
NCT05949593
Recruiting
This Phase 3, multicenter, double-masked, parallel-group, placebo-controlled, randomized, fixed-dose clinical study is designed to evaluate the efficacy and safety of tinlarebant (LBS-008) in subjects diagnosed with GA.
Gender:
ALL
Ages:
Between 60 years and 85 years
Trial Updated:
02/12/2025
Locations: Belite Study Site, Hagerstown, Maryland
Conditions: Geographic Atrophy
Register for Updates
MRgFUS Pallidotomy for the Treatment of Task Specific Focal Hand Dystonia (TSFD)
NCT06367608
Recruiting
The purpose of this study is to assess the safety and effectiveness of MRI-guided focused ultrasound (MRgFUS) for treating task specific focal hand dystonias (TSFD). TSFD is a type of dystonia that affects hand movements during specific tasks such as writing, playing instruments or typing, often causing involuntarily movements or cramping.
Gender:
ALL
Ages:
Between 21 years and 75 years
Trial Updated:
02/11/2025
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Task-Specific Focal Dystonia
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Transcutaneous Spinal Cord Stimulation in Children with Incomplete Spinal Cord Injury
NCT06242873
Recruiting
Aim 1: Determine the safety and feasibility of administration of TSCS to children in a clinical setting. Participants will be randomly assigned to experimental (TSCS) or control (sham stimulation) groups. Both groups will receive eight-weeks of individualized gait training. We will measure adverse events, including pain and skin irritation, to determine safety as the primary outcome. Hypothesis 1: Administration of TSCS to children in a clinical setting will be safe based on similar safety outco... Read More
Gender:
ALL
Ages:
Between 3 years and 16 years
Trial Updated:
02/11/2025
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Spinal Cord Injuries
Register for Updates
Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care
NCT04601064
Recruiting
This is a research study to assess the effectiveness of a peer-led collaborative care model for integrating treatment for substance use and or mental health disorders into HIV care settings. Depending on whether or not participants enroll in this study, participants will be assigned randomly (by chance, like drawing a number from a hat) to one of two groups. In group 1, participants would receive usual clinical care. In group 2, participants would work with a peer-case manager who would help su... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
02/11/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: HIV Infections, Substance Use Disorders, Mental Health Disorder, Addiction, Opioid Use, Drug Use
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Padeliporfin VTP Using Robotic Assisted Bronchoscopy in Peripheral Lung Cancer
NCT05918783
Recruiting
Phase 1/1b, safety, feasibility, and light dose titration study followed by further study of therapeutic ablation effects. Patients with high risk of peripheral primary lung cancer, stage 1A1/1A2, for whom surgical treatment is planned, will be recruited. Surgery will be performed at 5-21 days following the VTP procedure. Study intervention: robotic assisted bronchoscopic Padeliporfin VTP lung ablation: vascular targeted photodynamic therapy using Padeliporfin photosensitizer.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2025
Locations: Johns Hopkins University School of Medicine, Baltimore, Maryland
Conditions: Peripheral Lung Tumor
Register for Updates
Study of Healthy Cohort for Early Detection of Cancer
NCT05193305
Recruiting
Cancer produces a significant burden on society with a majority diagnosed at late stages when the chance of cure is low. Early diagnosis improves patient outcomes. Data consisting of lifestyle factors, medications, physical activity, years before conventional cancer diagnosis is also worthwhile for to determine early detection. This is only achievable with longitudinal tracking of a large number of healthy individuals and identifying those who do develop cancer over time.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Healthy
Register for Updates
Diagnostic Strategies, Risk Assessment and Progression of Pancreatic Cysts
NCT04473794
Recruiting
The aims of this study are to determine the natural history of pancreatic cysts and to propose and prospectively validate a diagnostic approach and model for prediction of mucinous versus non-mucinous, and malignant versus non-malignant, pancreatic cysts using a combination of clinical, radiologic, and biomarker characteristics.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/10/2025
Locations: The Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Pancreatic Neoplasms, Pancreas Cancer
Register for Updates
A Study of AK117 in Combination With Azacitidine in Patients With Myelodysplastic Syndromes
NCT06196203
Recruiting
This is a Phase 2 randomized, double-blind, placebo-controlled, multicenter study evaluating the efficacy and safety of AK117 or placebo, combined with azacitidine in patients with newly diagnosed higher-risk myelodysplastic syndromes (HR-MDS).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/09/2025
Locations: American Oncology Partners, PA (The Center for Cancer and Blood Disorders-Bethesda), Bethesda, Maryland
Conditions: Higher-risk Myelodysplastic Syndromes
Register for Updates
Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma
NCT01042015
Recruiting
The goal of this study is to rapidly cool trauma victims who have suffered cardiac arrest from bleeding with a flush of ice-cold sodium chloride to preserve the patient to enable surgical control of bleeding, followed by delayed resuscitation with cardiopulmonary bypass.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
02/09/2025
Locations: University of Maryland, Baltimore, Maryland
Conditions: Cardiac Arrest From Trauma
Register for Updates