Maryland is currently home to 2668 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
NCT05301608
Recruiting
This research study will use computerized tasks, electroencephalography (EEG), and magnetic resonance imaging (MRI) to look at how the drug psilocybin, a naturally occurring compound contained in hundreds of species of psychoactive mushrooms, changes thoughts and brain activity.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/16/2024
Locations: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Conditions: Healthy
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Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia
NCT05184335
Recruiting
This study is to evaluate the effect and safety of Brilaroxazine in patients with acute schizophrenia compared to the placebo short and long-term. Brilaroxazine will be given at fixed doses of 15 mg or 50 mg once daily over 4 weeks, then in the long-term flexible doses 15-50mg daily over a period of 52 weeks.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/16/2024
Locations: Reviva site, Gaithersburg, Maryland
Conditions: Schizophrenia
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A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer
NCT05154487
Recruiting
This is a 2 stage multi-center study designed to evaluate the efficacy of the combination of alpelisib and fulvestrant in patients with PIK3CA-mutated ER-positive endometrioid endometrial cancers by estimating the objective response rate (ORR). Treatment will continue until either unacceptable toxicity, progression of disease, or investigator/patient request for withdrawal.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
12/16/2024
Locations: Johns Hopkins Medicine, Baltimore, Maryland
Conditions: Endometroid Endometrial Cancer
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Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
NCT04620759
Recruiting
The purpose of this study is to determine whether psilocybin, a hallucinogenic drug, is effective in reducing depressive symptoms and amount of drinking in patients with co-occurring Major Depressive Disorder (MDD) and Alcohol Use Disorder (AUD).
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
12/16/2024
Locations: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Conditions: Major Depressive Disorder, Alcohol Use Disorder
Register for Updates
Paradoxical Tuberculosis Reactions in Patients Without HIV Infection
NCT04052022
Recruiting
Background: Most people with tuberculosis (TB) feel better after starting treatment. But for some people, the opposite happens. They may feel better at first, but then suddenly get worse. This is a paradoxical reaction. Researchers want to better understand what causes this reaction and what happens after someone has it. Objective: To learn about paradoxical reactions to TB treatment. Eligibility: Adults 18 and older diagnosed with confirmed or suspected TB and currently on treatment for at... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/14/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Tuberculosis
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Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis
NCT05252754
Recruiting
This research is being done to see if using oral tacrolimus before endoscopy, can prevent pancreatitis that may occur after ERCP (a type of gastrointestinal endoscopy).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/13/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Post-ERCP Acute Pancreatitis
Register for Updates
HCRN Core Data Project: Characterizing Patient Populations in the Hydrocephalus Clinical Research Network (HCRN)
NCT00670735
Recruiting
The Hydrocephalus Clinical Research Network (HCRN) has been established by philanthropic funding to conduct multi-institutional research (clinical trials and observational studies) on pediatric hydrocephalus. In addition to philanthropic funding, the HCRN has also received an NIH NINDS Challenge Grant to support the network infrastructure which allows for the conduct of this and other network studies. The HCRN consists of multiple Clinical Centers and the Data Coordinating Center (DCC). The HCRN... Read More
Gender:
ALL
Ages:
18 years and below
Trial Updated:
12/13/2024
Locations: Johns Hopkins Children's Center, Baltimore, Maryland
Conditions: Pediatric Hydrocephalus
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A Study of Cebranopadol for the Treatment of Acute Pain After Bunionectomy
NCT06423703
Recruiting
The purpose of this study is to evaluate the efficacy and safety of Cebranopadol for acute pain after a bunionectomy.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
12/12/2024
Locations: ALLEVIATE 2 Site 001105, Pasadena, Maryland
Conditions: Acute Pain
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Measuring Acute Drug Demand in Humans
NCT05829655
Recruiting
This research is being done to evaluate whether suvorexant may reduce the use of, subjective liking, and demand for various drugs.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/12/2024
Locations: Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Opioid Use Disorder, Opioid Dependence
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A Patient-centered Trial of a Process-of-care Intervention in Hospitalized AKI Patients: the COPE-AKI Trial
NCT05805709
Recruiting
The COPE-AKI study is a randomized, pragmatic, parallel-arm trial comparing a multimodal intervention to usual care on hospital-free days through 90 days of study follow up. The primary study hypothesis is that patients randomized to the intervention will have increased odds of more hospital-free days through 90 days (primary clinical) compared to those randomized to usual care. Key secondary hypotheses will investigate the impact of the intervention on rates of major adverse kidney events, rate... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Acute Kidney Injury
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Trial of Cemiplimab, or Cemip-Chemo Followed by Biomarker-guided Treatment for Pts w/HPV H&N Ca
NCT04988074
Recruiting
To determine if it is feasible to use neoadjuvant immunotherapy (or immunotherapy plus chemotherapy) to reduce treatment intensity and improve long-term quality of life while maintaining very high cure rates.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: HPV-Related Squamous Cell Carcinoma
Register for Updates
International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry
NCT04496687
Recruiting
The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD. The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its re... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/12/2024
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Spontaneous Coronary Artery Dissection
Register for Updates