Maryland is currently home to 2678 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Chemoimmunotherapy Combined with Hyperthermia and Spatially-Fractionated Radiotherapy in Advanced Biliary Tract Cancer
NCT06546969
Recruiting
This study is being done to see if the investigators can improve the outcome of patients with biliary tract cancer that do not qualify for surgery. This study will compare the effects, good and/or bad, of using a combination of standard of care chemoimmunotherapy, with the addition of radiation and deep hyperthermia. In this study, participants will be receiving standard of care chemoimmunotherapy (gemcitabine, cisplatin, and durvalumab), radiation (spatially fractionated radiation therapy), and... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
11/25/2024
Locations: Maryland Proton Treatment Center, Baltimore, Maryland
Conditions: Biliary Tract Cancer, Cholangiocarcinoma
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Partners in Children's Health (CSN): a Randomized Trial of an Attachment Based Intervention
NCT06002685
Recruiting
The goal of this randomized controlled trial is to evaluate the impacts of an attachment-based intervention (Attachment Biobehavioral Catch-Up (ABC) and Home Book-of-the-Week (HBOW) program on emerging health outcomes (i.e., common childhood illnesses, body mass index, and sleep) in low-income Latino children (N=260; 9 months at enrollment). It is hypothesized that children randomized to ABC will have better health outcomes in comparison to the HBOW control group.
Gender:
ALL
Ages:
Between 8 months and 12 months
Trial Updated:
11/25/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Respiratory Disease, Inflammation, Insufficient Sleep, Digestive Disease, Skin Conditions, Body Mass Index, Infections, Allergies, Congestion, Antibiotic Use, Overweight and Obesity
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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY
NCT04916210
Recruiting
The overall goal of the DISCOVERY study is to better understand what factors contribute to changes in cognitive (i.e., thinking and memory) abilities in patients who experienced a stroke. The purpose of the study is to help doctors identify patients at risk for dementia (decline in memory, thinking and other mental abilities that significantly affects daily functioning) after their stroke so that future treatments may be developed to improve outcomes in stroke patients. For this study, a "stroke... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Dementia, Vascular, Mild Cognitive Impairment, Vascular Cognitive Impairment
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GammaPod Dose Escalation Radiation for Early Stage Breast Cancer
NCT04234386
Recruiting
The GammaPod machine was made by Xcision Medical Systems and is already FDA cleared to deliver focused radiation within the breast. Unlike current radiation machines, the GammaPod was designed specifically for treating breast cancer. The GammaPod can pinpoint radiation to the tumor bed in the breast which lowers the amount of radiation to nearby tissues. The machine uses a breast cup system to hold the breast in place for the treatment. This breast cup system was tested at MSGCCC (Marlene Stewar... Read More
Gender:
FEMALE
Ages:
45 years and above
Trial Updated:
11/25/2024
Locations: UMMC, Baltimore, Maryland
Conditions: Breast Cancer
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Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma
NCT03860883
Recruiting
Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: MedStar Franklin Square Medical Center, Baltimore, Maryland
Conditions: Cutaneous Melanoma, Stage II
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GammaPod Registry and Quality of Life Nomogram
NCT03562273
Recruiting
This study is a prospective, single arm study (registry) summarizing patient-level adverse-event and tumor outcomes as well as a number of feasibility and dosimetric characteristics of delivering a single-fraction boost with the GammaPod.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/25/2024
Locations: Upper Chesapeake Health, Bel Air, Maryland
Conditions: Breast Cancer Female
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Covid-19 Long Haul Preventative and Health Promotion Care Clinical Trial Acceleration Program.
NCT06441955
Recruiting
Investigators are conducting a study on alternative treatments for patients who have received an current or previous positive COVID-19 diagnosis with mild-serve symptoms or undiagnosable condition after testing positive for severe acute COVID-19 infection and are experiencing long-haul symptoms. The symptoms of long COVID can include extreme tiredness (fatigue), shortness of breath, memory and concentration issues (brain fog), heart palpitations, dizziness, joint pain, muscle aches, cough, heada... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
11/24/2024
Locations: NIH Clinical Center, Bethesda, Maryland
Conditions: COVID-19, Long Haul
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Is Physical Therapy Clearance Before Arthroplasty Home Discharge Necessary?
NCT05858086
Recruiting
Conventionally, physical therapy (PT) clearance is sought before total joint arthroplasty (TJA) discharge. However, PT staffing limitations may preclude same-day discharge in patients having surgery late in the day. Failed same-day discharge in eligible TJA patients results in unnecessary hospital bed occupancy, which increases costs, limits operating room throughput for patients requiring inpatient admission, and introduces risks associated with longer length-of-stay. In collaboration with an... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
11/23/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Physical Therapy, Total Joint Arthroplasty, Same-day Discharge
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Proper Duration of Suppressive Antibiotic Therapy After Debridement, Antibiotics, and Implant Retention
NCT05495815
Recruiting
Multiple studies have demonstrated oral suppressive antibiotic therapy (SAT), after intravenous antibiotics, maximizes reoperation-free survival of total joint arthroplasty (TJA) debridement, antibiotics, and implant retention (DAIR) for acute periprosthetic joint infection (PJI). However, little is known regarding sequelae of SAT after DAIR for PJI. Prior studies have small or heterogeneous patient cohorts, variable antibiotic regimens, arrive at disparate conclusions, and do not establish anti... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/23/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Periprosthetic Joint Infection, Antibiotic Suppression
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Enhancing Care & Outcomes for Patients During the First Postpartum Year
NCT06615076
Recruiting
The United States is in the midst of a maternal mortality and morbidity crisis, with more than half of maternal deaths occurring within the first postpartum year. Patients with hypertensive disorders of pregnancy (HDP) and diabetes have been found to be particularly high-risk, as they have a significantly increased risk for the development of cardiovascular disease in the long-term postpartum period. Traditionally, postpartum care has consisted of a single office visit at six weeks postpartum. R... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Postpartum Period, Pregnancy, Hypertension, Pregnancy Induced
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Development and Evaluation of a PrEP Decision Aid for Women Seeking Domestic Violence Services in Baltimore
NCT05614492
Recruiting
This study is designed to develop and test an individual decision aid for pre-exposure prophylaxis (PrEP) tailored to Black women who have been exposed to intimate partner violence and are working with a domestic violence service provider. three different ways of delivering the tailored decision aid are being tested: 1) as an individual tool; or 2) as a shared decision-making tool with a domestic violence advocate; as compared to generalized information. The goal of decision aid will be to addre... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: Springboard Community Services - Baltimore City Office, Baltimore, Maryland
Conditions: HIV, Violence, Gender-Based, Pre-Exposure Prophylaxis
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Pilot Study to Investigate Magnetic Resonance (MR) Image Guided Focal Therapy in Prostate Cancer
NCT04808427
Recruiting
Background: The ability to treat early prostate cancer is still limited. Thermal ablation methods are being tested for focal prostate cancer therapy. Researchers want to improve on these methods. Objective: To understand if Transurethral UltraSound Ablation (TULSA) in combination with MRI guidance is useful to treat localized prostate cancer. Eligibility: English-speaking adults ages 18 and older with localized prostate cancer that can be seen on MRI and can be treated by thermal ablation.... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
11/22/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Prostate Cancer
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