Maryland is currently home to 2680 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
The APS Phenotyping Study
NCT06521502
Recruiting
The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis. This study will also generate a biobank of specimens collected from these patients that will be available to investigators for future studies of ARDS, sepsis, and/or pneumonia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Johns Hopkins Univeristy, Baltimore, Maryland
Conditions: ARDS, Sepsis, Pneumonia
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Artificial Intelligence-based Video Analysis to Detect Infantile Spasms
NCT06315829
Recruiting
Infantile spasms are a type of seizure linked to developmental issues. Unfortunately, they are often misdiagnosed, causing delays in treatment. The purpose of this study is to develop a computer program that can reliably differentiate infantile spasms from similar, yet benign movements in videos. This computer program will learn from videos taken by parents of study participants. Quickly recognizing and treating infantile spasms is crucial for ensuring the best developmental outcomes.
Gender:
ALL
Ages:
2 years and below
Trial Updated:
08/26/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Infantile Spasms
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Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies
NCT05995821
Recruiting
This research is being done to collect and store biological specimens (biospecimens) from people with cancer, regardless of tumor type, who are receiving treatments known or thought to have an effect on the immune system. The goal of this discovery and exploratory study is to: * Understand changes in the immune system associated with various cancer treatments, in order to better design new therapies or tests to predict how these treatments might work. * Identify risk factors for those who go o... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/26/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Head and Neck Cancer, Lung Cancer, Gastrointestinal Cancer
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Examining the Role of the Orexin System in Sleep and Stress in Persons With Opioid Use Disorder
NCT04287062
Recruiting
This study is designed to elucidate the role of the orexin neurotransmitter system in sleep disturbance and circadian rhythms of stress that might in turn influence relapse behaviors in persons on medication-assisted treatments (MAT) who are in early recovery from opioid use disorder (OUD). Briefly, the study will enroll recently abstinent OUD patients (N=200) maintained on either extended-release naltrexone (XR-NTX), buprenorphine, or methadone. Within each MAT group, participants will be rando... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
08/26/2024
Locations: Man Alive Inc., Lane Treatment Center, Baltimore, Maryland
Conditions: Sleep Disturbance, Opioid-use Disorder
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Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
NCT05548283
Recruiting
The purpose of this study is to look at pulmonary exacerbations in people with cystic fibrosis (CF) that need to be treated with antibiotics given through a tube inserted into a vein (intravenous or IV). A pulmonary exacerbation is a worsening of respiratory symptoms in people with CF that needs medical intervention. Both doctors and CF patients are trying to understand the best way to treat pulmonary exacerbations. This study is trying to answer the following questions about treating a pulmonar... Read More
Gender:
ALL
Ages:
6 years and above
Trial Updated:
08/23/2024
Locations: John Hopkins Hospital, Baltimore, Maryland
Conditions: Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
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HPV in Sinonasal Ca: Retrospective Analysis Association of Human Papilloma Virus (HPV) Serology and Behavioral Risk Factors
NCT04979000
Recruiting
This is a case-control study designed to evaluate the role of anatomic site, gender and race in human papillomavirus-associated head and neck squamous cell cancers (HNSCC). We will explore the role of HPV, tobacco, alcohol and drug use, in HNSCC by tumor site with particular emphasis on the sinonasal cavity as well as differences in risk factors for HPV-positive HNSCC by gender and race.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/23/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Sinonasal Carcinoma, HPV-Related Squamous Cell Carcinoma
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S1803, Lenalidomide +/- Daratumumab/rHuPh20 as Post-ASCT Maintenance for MM w/MRD to Direct Therapy Duration
NCT04071457
Recruiting
Patients are enrolled to screening (Reg Step 1) prior to or after ASCT but prior to Reg Step 2. Patients are followed until they will begin Maintenance and then registered to Reg Step 2 (first randomization). Patients are randomized between Lenalidomide for 2 years and Lenalidomide + Daratumumab/rHuPH20. After 2 years of Maintenance, MRD is assessed to guide further therapy. MRD-positive patients will continue with the assigned treatment. MRD-negative patients will be further randomized (Reg Ste... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
08/21/2024
Locations: Greater Baltimore Medical Center, Baltimore, Maryland
Conditions: Multiple Myeloma
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PKD Clinical and Translational Core Study
NCT01873235
Recruiting
Advances in our understanding of the pathogenesis of autosomal dominant polycystic kidney disease (ADPKD) have opened up possibilities of new therapies to prevent disease progression. High quality clinical investigations in patients with ADPKD, however, pose significant challenges to investigators including limited access to patients with ADPKD,insufficient guidance by experienced investigators and lack of resources to conduct these studies. The Polycystic Kidney Disease Research Clinical and T... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/21/2024
Locations: University of Maryland School of Medicine General Clinical Research Center, Baltimore, Maryland
Conditions: Polycystic Kidney Disease
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Implementation of Asthma Community Home and School Management Program (Asthma CHAMPS)
NCT05814510
Recruiting
The long-term goal is to implement an evidence-based asthma intervention based on the Center for Disease Control's recommended framework (EXHALE) within Baltimore City Public Schools (BCPS). As part of a stepped wedge pragmatic trial the investigators will: 1. Evaluate the effectiveness of a tailored implementation plan of Asthma CHAMPS in 32 Baltimore city elementary schools to reduce asthma disparities. 2. Conduct a pragmatic trail using a stepped wedge design to evaluate implementation of a... Read More
Gender:
ALL
Ages:
All
Trial Updated:
08/20/2024
Locations: Baltimore City Public Schools, Baltimore, Maryland
Conditions: Asthma in Children
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EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
NCT05476276
Recruiting
This is a Platform Protocol to perform Phase II clinical trials in The Early Phase Pain Investigation Clinical Network (EPPIC-Net), under The Helping to End Addiction Long-termSM Initiative, or NIH HEAL InitiativeSM, related to the treatment of Painful Diabetic Peripheral Neuropathy (PDPN) in a platform setting to test multiple assets under a single protocol.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
08/20/2024
Locations: University of Maryland - Baltimore, Baltimore, Maryland
Conditions: Painful Diabetic Neuropathy
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Blended Reality Immersion for Geriatric Head Trauma: The BRIGHT Study
NCT06074328
Recruiting
Traumatic brain injury (TBI) is a major public health concern, particularly among older adults (OAs) ≥ 65 years of age. Each year in the United States, TBI results in over 600,000 emergency department visits and hospitalizations among OAs. Mild TBI (mTBI) accounts for 80% of all TBI in OAs and is quite understudied in this rapidly growing population. mTBI, is mild in name only, as it can result in dysfunction in multiple cognitive domains, including attention, processing speed, executive functio... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
08/18/2024
Locations: R Adams Cowley Shock Trauma Center, Baltimore, Maryland
Conditions: Traumatic Brain Injury
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Vaginal Estradiol vs Oral Beta-3 Agonist for Overactive Bladder Syndrome
NCT05221021
Recruiting
A single site, double-blinded, randomized controlled trial for postmenopausal women with urinary frequency, urgency, nocturia with or without urgency urinary incontinence symptoms. Patient's will be randomized between 0.01% vaginal estradiol cream with placebo oral pill or daily 50 milligrams oral Mirabegron with a placebo vaginal cream for 12 weeks.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
08/15/2024
Locations: Walter Reed National Military Medical Center, Bethesda, Maryland
Conditions: Overactive Bladder Syndrome
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