Maryland is currently home to 2690 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases
NCT03223922
Recruiting
This is a trial that evaluates the preservation of cognition and neuropsychiatric function following genu-sparing whole brain radiation in patients with brain metastases.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/05/2024
Locations: The SKCCC at Johns Hopkins, Baltimore, Maryland
Conditions: Brain Metastases
Register for Updates
Image-Guided Gynecologic Brachytherapy
NCT02993900
Recruiting
This research is being done to evaluate multimodality imaging, including magnetic resonance imaging-guided therapy (MRT), as a possible treatment for gynecologic cancers. The therapy takes place in the Department of Radiation Oncology at the Johns Hopkins SKCCC. The purpose of this study is to investigate the ability of MRI to successfully guide the placement of the brachytherapy applicator necessary to treat participants' gynecologic cancer. The Investigators want to see if the use of MRI will... Read More
Gender:
FEMALE
Ages:
Between 18 years and 100 years
Trial Updated:
06/05/2024
Locations: The SKCCC at Johns Hopkins, Baltimore, Maryland
Conditions: Cervical Cancer, Uterine Cancer, Vaginal Cancer, Vulvar Cancer, Bladder Cancer
Register for Updates
Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension
NCT02682511
Recruiting
The purpose of this phase 2 multicenter, randomized, double-blind, placebo-controlled, study is to assess the safety and efficacy of ifetroban in patients with diffuse cutaneous systemic SSc (dcSSc) or SSc-associated pulmonary arterial hypertension (SSc-PAH).
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
06/05/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Scleroderma, Diffuse, Scleroderma, Systemic, Scleroderma, Limited, Sclerosis, Progressive Systemic, Skin Diseases, Connective Tissue Diseases, Pathologic Processes, Autoimmune Diseases
Register for Updates
Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme
NCT02177578
Recruiting
In this study patients will be treated with 6 weeks of radiation therapy plus temozolomide chemotherapy according to the standard of care. However, the radiation treatment plan will be modified to deliver an higher than routine radiation dose to the subventricular zone which is an area of the brain that contains stem cells that some scientists believe may contribute to glioblastoma recurrence. The purpose of the study is to see if the tumor is controlled for a longer period of time in patients t... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
06/05/2024
Locations: The SKCCC at Johns Hopkins, Baltimore, Maryland
Conditions: Glioblastoma Multiforme
Register for Updates
MRI for Assessing Prostate Cancer Response
NCT01607008
Recruiting
Prostate cancer is one of most common cancers in America, affecting 1 in 6 men. External beam radiation therapy is one of the common methods to treat prostate cancer. Although radiotherapy is effective, side effects to the adjacent normal organs limit the therapeutic ratio. Those side effects are usually associated with the radiation damage of the normal tissue surrounding prostate, e.g. bladder, urethra and rectum etc. Both effectiveness and the side effects of radiation treatment are often acc... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
06/05/2024
Locations: The Sidney Kimmel Comprehsensive Cancer Center at Johns Hopkins, Baltimore, Maryland
Conditions: Prostate Cancer
Register for Updates
T CELL THERAPY OPPOSING NOVEL COVID-19 INFECTION IN IMMUNOCOMPROMISED PATIENTS
NCT05141058
Recruiting
This is an open label, phase I dose-escalation study to evaluate the safety of coronavirus-specific T cell (CST) therapy for prevention of SARS-CoV-2 infection in immunocompromised patients following hematopoietic stem cell transplantation (HSCT). Participants will receive donor-derived CSTs for prevention of SARS-CoV-2 infection after HSCT (≥28 days and \<4 months after HSCT). In this dose escalation trial, three doses (1x107/m2, 2x107/m2, and 4x107/m2) will be tested for safety, with study a... Read More
Gender:
ALL
Ages:
Between 12 years and 80 years
Trial Updated:
06/04/2024
Locations: The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland
Conditions: SARS-CoV-2 Infection
Register for Updates
Gleolan for Visualization of Newly Diagnosed or Recurrent Ovarian Cancer (OVA-302)
NCT05804370
Recruiting
This Phase 3 study is designed to investigate the safety, diagnostic performance, and clinical usefulness of Gleolan for the real-time detection and visualization of epithelial ovarian cancer tumors during debulking surgery. The study is planned to run for about 18 months with individual study participation lasting about two (2) weeks.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
06/03/2024
Locations: Luminis Health Anne Arundel Medical Center, Annapolis, Maryland
Conditions: Ovarian Cancer
Register for Updates
Combination Radiotherapy and Radiopharmaceutical Therapy Treatment Planning for Thyroid Cancer
NCT04892303
Recruiting
The goal of this study is to evaluate combined radioactive iodine (RAI, 131-I) and external beam radiotherapy (XRT) to optimize the radiation dose delivered to treat well differentiated thyroid cancers (DTC) with iodine-avid metastases. The investigators hypothesize that precise dosimetric planning will permit this combined RAI-XRT radiotherapeutic approach to be safe and permit higher tumor radiation doses than could otherwise be delivered. Patients with metastatic well-differentiated DTC) that... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
06/03/2024
Locations: The Johns Hopkins SKCCC, Baltimore, Maryland
Conditions: Recurrent Thyroid Cancer
Register for Updates
Tendon Transfer Rotator Cuff Tear
NCT04588506
Recruiting
This is a prospective randomized study on using muscle tendons to repair tears of the muscles on the shoulder. There are 3 muscles covering the shoulder joint- supraspinatus, infraspinatus and subscapularis. Large tears involving these muscles can be treated by using some muscle from another location of the body known as Tendon transfer techniques. These muscle tendons may be from the lower back (Latissimus Dorsi), upper pack (lower trapezius) or chest (pectoralis). There are currently no studie... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
06/03/2024
Locations: U of Maryland Baltimore, Baltimore, Maryland
Conditions: Rotator Cuff Tears
Register for Updates
Biomarker Validation in Motor System Physiology in Attention Deficit Hyperactivity Disorder
NCT04421248
Recruiting
Attention-Deficit/Hyperactivity Disorder (ADHD) is the most commonly diagnosed neurobehavioral disorder in childhood. Children with ADHD struggle in school due to problems with attention and high levels of impulsivity and hyperactivity. They are at substantially increased risk for long-term difficulties into adulthood, including academic underachievement, substance abuse, and criminal behavior. The diagnosis of ADHD, which is based on subjective ratings by parents and teachers, likely results fr... Read More
Gender:
ALL
Ages:
Between 8 years and 12 years
Trial Updated:
05/31/2024
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Attention Deficit Hyperactivity Disorder Combined
Register for Updates
1911GCCC: Galeterone or Galeterone With Gemcitabine for Patients With Metastatic Pancreatic Adenocarcinoma
NCT04098081
Recruiting
Assess the effectiveness of galeterone in advanced pancreatic adenocarcinoma
Gender:
ALL
Ages:
18 years and above
Trial Updated:
05/31/2024
Locations: University of Maryland Medical Center, Baltimore, Maryland
Conditions: Advanced Pancreatic Cancer
Register for Updates
A Post-Approval Registry for Exablate 4000 Type 1.0 and Type 1.1 for Unilateral Pallidotomy for the Treatment of Advanced, Idiopathic Parkinson's Disease With Medication-refractory Moderate to Severe Motor Complications
NCT05539196
Recruiting
This registry is a prospective, multicenter, international, single arm, observational post-approval registry with follow-up at 3, 6, and 12 months, and annually for 5 years. The proposed registry will enroll 60 subjects and will be conducted at approximately 10 centers worldwide.
Gender:
ALL
Ages:
Between 30 years and 99 years
Trial Updated:
05/30/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Movement Disorders, Neurology, Parkinsons Disease
Register for Updates