Maryland is currently home to 2864 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention
NCT05973838
Recruiting
The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce polysubstance use among patients with OUD and polysubstance use in an underserved, rural area. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this hybrid, Type-1 effectiveness-implementation randomized co... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/24/2024
Locations: University of Maryland Baltimore (UMD Drug Treatment Center), Baltimore, Maryland
Conditions: Polysubstance Addiction, Opioid Medication Assisted Treatment, Treatment Adherence, Retention in Care, Substance-Related Disorders
Register for Updates
Pilot Prospective Study for PET-CT Imaging in Participants With Relapsed/Refractory Acute Leukemias
NCT05969002
Recruiting
Background Acute lymphoblastic leukemia (ALL) accounts for about 25% of childhood cancers and for about 20% of adult leukemias. The disease can be treated with CAR T-cell infusion but non-central nervous system (CNS) extramedullary disease (EMD) is associated with lower rates of complete remission. 18-fludeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) has been shown to be effective for detection of non-CNS EMD in ALL. Pre and post CAR T-cell infusion may help to... Read More
Gender:
All
Ages:
Between 5 years and 39 years
Trial Updated:
04/24/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: B Cell, Acute Lymphoblastic Leukemia, Relapsed/Refractory
Register for Updates
Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis (TETON-PPF)
NCT05943535
Recruiting
Study RIN-PF-305 is designed to evaluate the safety and efficacy of inhaled treprostinil in subjects with progressive pulmonary fibrosis (PPF) over a 52-week period.
Gender:
All
Ages:
18 years and above
Trial Updated:
04/24/2024
Locations: Adventist Healthcare White Oak Medical Center, Silver Spring, Maryland
Conditions: Progressive Pulmonary Fibrosis, Interstitial Lung Disease
Register for Updates
A Study to Evaluate Similarity of ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Resected Melanoma
NCT05907122
Recruiting
The purpose of this study is to investigate the pharmacokinetic (PK) similarity and efficacy, safety, and immunogenicity of ABP 206 compared with OPDIVO® (nivolumab) in subjects with resected advanced melanoma.
Gender:
All
Ages:
Between 18 years and 99 years
Trial Updated:
04/24/2024
Locations: University of Maryland Medical Center-Greenebaum Cancer Ctr, Baltimore, Maryland
Conditions: Melanoma
Register for Updates
BPL-003 Efficacy and Safety in Treatment Resistant Depression
NCT05870540
Recruiting
This is a Phase 2 study randomized, quadruple masked, multi-center study designed to investigate the efficacy and safety of a single dose of BPL-003 combined with psychological support in patients with treatment resistant depression (TRD).
Gender:
All
Ages:
Between 18 years and 75 years
Trial Updated:
04/24/2024
Locations: Sunstone Medical PC (Sunstone Therapies / Aquilino Cancer Center), Rockville, Maryland
Conditions: Treatment Resistant Depression
Register for Updates
A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib
NCT05734105
Recruiting
This is a Phase 3, 2-arm, randomized, open-label, global, multicenter study comparing the efficacy of ripretinib to sunitinib in participants with GIST who progressed on first-line treatment with imatinib, harbor co-occurring KIT exons 11+17/18 mutations, and are without KIT exon 9, 13, or 14 mutations. Upon disease progression as determined by an independent radiologic review, participants randomized to sunitinib will be given the option to either crossover to receive ripretinib 150 mg QD or di... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/24/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: GIST
Register for Updates
A Study to Evaluate Rocatinlimab (AMG 451) in Adolescent Subjects With Moderate-to-severe Atopic Dermatitis (AD)
NCT05704738
Recruiting
The purpose of this study is to evaluate the efficacy and safety of rocatinlimab in monotherapy and combination therapy treatment in adolescent subjects.
Gender:
All
Ages:
Between 12 years and 17 years
Trial Updated:
04/24/2024
Locations: Derm Associates, PC, Rockville, Maryland
Conditions: Atopic Dermatitis
Register for Updates
Resiliency in U.S. Air Force Personnel
NCT05700435
Recruiting
The goal of this clinical trial is to examine the effectiveness of the Stress Management and Resilience Training (SMART) in increasing resilience in a population of U.S. Air Force personnel at Joint Base Andrews, Joint Base San Antonio-Lackland, Nellis Air Force Base, and Wright-Patterson Air Force Base. The main questions it aims to answer are: When delivered in real-world conditions, to what extent does SMART increase levels of resiliency and decrease levels of stress in a sample of active c... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
04/24/2024
Locations: Johns Hopkins University, School of Nursing (Joint Base Andrews), Baltimore, Maryland
Conditions: Stress, Quality, Anxiety, Resilience
Register for Updates
Long-term Extension Study of Ligelizumab in Food Allergy
NCT05678959
Recruiting
This is an extension study to evaluate the long-term safety and efficacy of ligelizumab in particiants who have completed a ligelizumab Phase III study in food allergy.
Gender:
All
Ages:
Between 6 years and 57 years
Trial Updated:
04/24/2024
Locations: Johns Hopkins Childrens Center, Baltimore, Maryland
Conditions: Food Allergy
Register for Updates
A Phase 1/2 Study of VX-522 in Participants With Cystic Fibrosis (CF)
NCT05668741
Recruiting
The purpose of this study is to evaluate the safety, and tolerability and efficacy of VX-522 in participants 18 years of age and older with cystic fibrosis and a cystic fibrosis transmembrane conductance regulator (CFTR) genotype not responsive to CFTR modulator therapy.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
04/24/2024
Locations: Baltimore - Early Phase Clinical Unit, Baltimore, Maryland
Conditions: Cystic Fibrosis
Register for Updates
Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)
NCT05624749
Recruiting
The trial will evaluate efficacy, safety and tolerability of ianalumab compared to placebo, given as monthly subcutaneous (s.c.) injection on top of standard-of-care (SoC) treatment in participants with active systemic lupus erythematosus (SLE).
Gender:
All
Ages:
12 years and above
Trial Updated:
04/24/2024
Locations: University Of Maryland Rheumatology, Baltimore, Maryland
Conditions: Systemic Lupus Erythematosus
Register for Updates
Universal Rare Gene Study: A Registry and Natural History Study of Retinal Dystrophies Associated With Rare Disease-Causing Genetic Variants
NCT05589714
Recruiting
This is an international, multicenter study with two components: Registry A standardized genetic screening and a prospective, standardized, cross-sectional clinical data collection Enrollment is open to all genes on the RD Rare Gene List Natural History Study A prospective, standardized, longitudinal Natural History Study Enrollment opens gene-by-gene, based on funding and within-gene Registry enrollment The study objectives are as follows. Registry Objectives Genotype Characterization Cro... Read More
Gender:
All
Ages:
4 years and above
Trial Updated:
04/24/2024
Locations: Johns Hopkins University, Wilmer Eye Institute, Baltimore, Maryland
Conditions: Inherited Retinal Degeneration, Retinitis Pigmentosa
Register for Updates