Wisconsin is currently home to 1327 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Milwaukee, Madison, Green Bay and Marshfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer
Recruiting
This phase II Lung-MAP treatment trial tests whether carboplatin and pemetrexed with or without selpercatinib works to shrink tumors in patients with RET fusion-positive non-small cell lung cancer that is stage IV or has not responded to previous RET directed therapy. Chemotherapy drugs, such as carboplatin and pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Selpercatinib may st... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: Duluth Clinic Ashland, Ashland, Wisconsin
Conditions: Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8, Stage IVB Lung Cancer AJCC v8
Three Good Things (3GT) - Intervention for Transitional Care Patients
Recruiting
Researchers are doing this research study to learn how the Three Good Things (3GT) Positive Psychology journaling activity affects symptoms of stress, depression, resilience, and happiness.
Gender:
All
Ages:
18 years and above
Trial Updated:
02/28/2023
Locations: Mayo Clinic Health System Bloomer Hospital, Bloomer, Wisconsin
Conditions: Positive Thinking, Psychology, Positive, Resilience, Psychological
Assessing the Clinical Benefit of Molecular Profiling in Patients With Solid Tumors
Recruiting
Many patients are treated for advanced cancer without knowledge of underlying molecular features that might indicate FDA approved therapies or potential eligibility for biomarker-selected clinical trials. The Strata Trial (STR-001-001) has been initiated by Strata Oncology to evaluate the clinical benefit of systematic comprehensive genomic profiling for participants with advanced cancer using real-world data and endpoints, while assessing the proportion of participants available for clinical t... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
02/23/2023
Locations: Gundersen Health System, La Crosse, Wisconsin
Conditions: Cancer, Adult Solid Tumor, Lymphoma, Multiple Myeloma
Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome
Recruiting
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by hyperextensible skin, joint hypermobility and additional connective tissue manifestations. For unclear reasons, hEDS is associated with many gastrointestinal (GI) and autonomic nervous system (ANS) complaints such as postural orthostatic tachycardia syndrome (POTS). This study will address the clinical relationship between hEDS/Hypermobile Spectrum Disorders and autonomic regulation and see if there is a b... Read More
Gender:
All
Ages:
Between 10 years and 18 years
Trial Updated:
02/22/2023
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome, Autonomic Nervous System Disease, Autonomic Nervous System Imbalance
Randomized Therapy In Status Epilepticus
Recruiting
This study will evaluate the effectiveness and safety of an investigational product (IP), intravenous (IV) ganaxolone, to treat participants with status epilepticus (SE).
Gender:
All
Ages:
12 years and above
Trial Updated:
02/22/2023
Locations: Marinus Research Site, Madison, Wisconsin
Conditions: Status Epilepticus
Human Cerebral Blood Flow Regulation
Recruiting
This study tests basic differences in how men and women control brain (cerebral) blood flow (CBF), at rest and under stress. The stress is low oxygen or high carbon dioxide. The investigators hypothesize that sex differences per se, plus sex hormone differences, drive different signals in blood vessels that change the way CBF is regulated. The investigators will test these mechanisms with medicine infusions during stress, and measure CBF using state-of-the-art MRI approaches. Research confoundin... Read More
Gender:
All
Ages:
Between 18 years and 40 years
Trial Updated:
02/21/2023
Locations: University of Wisconsin, Madison, Madison, Wisconsin
Conditions: Cerebral Arterial Diseases
SEAM Trial: Sutureless End to End Anastomosis by Magnetic Compression
Recruiting
The objectives of this study are to determine the safety and effectiveness of the SFM Anastomosis Device when used to create a small bowel anastomosis for patients undergoing ileostomy reversal as compared with a propensity-matched historic control group of patients who underwent ileostomy reversal using a conventional closure technique (sutures or stapler).
Gender:
All
Ages:
18 years and above
Trial Updated:
02/19/2023
Locations: The Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Retraction of Ileostomy
Impella Supported OPCABG
Recruiting
The present study introduces a novel approach to coronary revascularization through the use of a short term minimally-invasive left ventricular assist device (LVAD) to minimize myocardial injury and eliminate low output state during the perioperative period
Gender:
All
Ages:
18 years and above
Trial Updated:
02/17/2023
Locations: The Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: Ischemic Cardiomyopathy
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of Oral ARN-75039 in Healthy Adult Subjects
Recruiting
This is a randomized, double-blind, placebo-controlled study to assess the safety, tolerability, and pharmacokinetics (PK) of escalating single ascending dose (SAD) and multiple ascending doses (MAD) of ARN-75039 when administered by the oral route in healthy adult subjects. The SAD portion of the study will enroll approximately 40 subjects for a total duration of 6 weeks. A cohort of 8 subjects in the SAD portion of the study will be selected to assess food effect (including relative bioavailab... Read More
Gender:
All
Ages:
Between 18 years and 55 years
Trial Updated:
02/16/2023
Locations: Spaulding Clinical, LLC, West Bend, Wisconsin
Conditions: Lassa Virus Infection
A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects
Recruiting
The purpose of this study is to evaluate the efficacy and safety of 131I-MIBG in combination with Vorinostat in patients with Recurrent or Progressive neuroblastoma
Gender:
All
Ages:
1 year and above
Trial Updated:
02/15/2023
Locations: University of Wisconsin, American Family Children's Hospital and Clinical Science Center, Madison, Wisconsin
Conditions: Neuroblastoma, Neuroectodermal Tumors, Neoplasms
High-Intensity, Dynamic-stability Gait Training in People With Multiple Sclerosis
Recruiting
The goal of this clinical trial is to improve walking speed, balance, and walking in the community for people with multiple sclerosis. This trial involves intense exercise combined with walking on a shaky treadmill. Walking on a shaky treadmill helps to practice balance and intense exercise promotes the ability to walk faster and farther. In this study, participants will train with a combination of high or low intensity, and with a stable or shaky treadmill. Walking speed and endurance, balance... Read More
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
02/09/2023
Locations: Marquette University, Milwaukee, Wisconsin
Conditions: Multiple Sclerosis
A Study to Evaluate the Safety and Efficacy of JCAR017 in Pediatric Subjects With Relapsed/Refractory (r/r) B-cell Acute Lymphoblastic Leukemia (B-ALL) and B-cell Non-Hodgkin Lymphoma (B-NHL)
Recruiting
This is a Phase 1/2, open-label, single arm, multicohort study to evaluate the safety and efficacy of JCAR017 in pediatric subjects aged ≤ 25 years with CD19+ r/r B-ALL and B-NHL. Phase 1 will identify a recommended Phase 2 dose (RP2D). Phase 2 will evaluate the efficacy of JCAR017 RP2D in the following three disease cohorts: Cohort 1 (r/r B-ALL), Cohort 2 (MRD+ B-ALL) and Cohort 3 (r/r B-NHL, [DLBCL, BL, or PMBCL]). A Simon's Optimal two-stage study design will be applied to Cohort 1 and 2 in... Read More
Gender:
All
Ages:
25 years and below
Trial Updated:
02/08/2023
Locations: Local Institution - 168, Wauwatosa, Wisconsin
Conditions: Precursor Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Non-Hodgkin