Wisconsin is currently home to 1287 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Milwaukee, Madison, Green Bay and Marshfield. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Diagnostic Tests in Supra-Esophageal Gastroesophageal Reflux Disease (SE-GERD)
NCT05695846
Recruiting
After defining the manometric characteristics of UES incompetence associated with documented pharyngeal reflux, we will determine the reproducibility of manometric criteria for UES incompetence in prevention of pharyngeal reflux. We hypothesize that these criteria are comprised of either a single or constellation of manometric abnormalities. After determining the ability of externally applied cricoid cartilage pressure in preventing pharyngeal reflux, we further hypothesize that this approach wi... Read More
Gender:
ALL
Ages:
Between 20 years and 85 years
Trial Updated:
12/06/2024
Locations: Reza Shaker, Milwaukee, Wisconsin
Conditions: Gastroesophageal Reflux
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A Pilot Study of Local Anesthesia for Inguinal Hernia Surgery in Older Adults
NCT04706026
Recruiting
Inguinal hernia repair-the most common general surgery operation in the U.S.-provides a unique opportunity to improve outcomes for older patients by changing surgical practice. Nearly 80% of inguinal hernia operations are performed under general anesthesia versus 15-20% using local anesthesia, despite the absence of evidence for superiority. The choice of anesthesia has particular implications for older adults because they face substantial short- and long-term risk of cognitive and physical decl... Read More
Gender:
ALL
Ages:
65 years and above
Trial Updated:
12/06/2024
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Inguinal Hernia, Anesthesia, Local
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Brain Oxygen Optimization in Severe TBI, Phase 3
NCT03754114
Recruiting
BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure (ICP) and brain tissue oxygen (PbtO2) as compared to a strategy guided by treatment goals based on ICP monitoring alone. Both of these alternative strategies are used in s... Read More
Gender:
ALL
Ages:
14 years and above
Trial Updated:
12/06/2024
Locations: Froedtert Hospital, Milwaukee, Wisconsin
Conditions: Brain Injuries, Traumatic
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Screening in Trauma for Opioid Misuse Prevention - an Adaptive Intervention
NCT06527599
Recruiting
The primary objective of the present pilot, sequential, multiple-assignment randomized trial (Pilot SMART) is to determine feasibility and acceptability of delivering (from the perspective of the treatment/intervention staff) and receiving (from the perspective of the patient) an adaptive intervention for reducing rates of opioid misuse and preventing development of opioid use disorder in individuals hospitalized for traumatic injury. A complimentary secondary objective is to ensure the feasibil... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2024
Locations: UW Health, Madison, Wisconsin
Conditions: Opioid Misuse, Trauma Injury
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The TELENEO Trial: a Multicenter Trial of Telemedicine for Advanced Neonatal Resuscitations in Community Hospitals
NCT06087224
Recruiting
The purpose of this study is to evaluate the impact of real-time audio-video telemedicine consults with a neonatologist (termed teleneonatology) on the early health outcomes of at-risk neonates delivered in community hospitals.
Gender:
ALL
Ages:
0 days and above
Trial Updated:
12/05/2024
Locations: Prairie Ridge Health, Columbus, Wisconsin
Conditions: Death; Neonatal, Morbidity;Newborn
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Observational Study for Patients at Risk for Chronic Graft-Versus-Host Disease
NCT05919511
Recruiting
The purpose of this prospective observational study is to collect data from participants who have recently had an allogenic Stem Cell Transplant(alloSCT) and are at risk of Chronic Graft Versus Host Disease(cGVHD)
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Medical College of Wisconsin, Milwaukee, Wisconsin
Conditions: cGVHD
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US National OCS Heart Perfusion (OHP) Registry
NCT05915299
Recruiting
This Registry is a sponsor initiated, multi-center, observational post-approval registry with independent academic oversight.
Gender:
ALL
Ages:
All
Trial Updated:
12/05/2024
Locations: Aurora St Luke's Medical Center, Milwaukee, Wisconsin
Conditions: Heart Transplant
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Assessment of Combined CCM and ICD Device in HFrEF
NCT05855135
Recruiting
The goal of this clinical trial is to demonstrate that the OPTIMIZER® Integra CCM-D System (the "CCM-D System") can safely and effective convert induced ventricular fibrillation (VF) and spontaneous ventricular tachycardia and/or ventricular fibrillation (VT/VF) episodes in subjects with Stage C or D heart failure who remain symptomatic despite being on guideline-directed medical therapy (GDMT), are not indicated for cardiac resynchronization therapy (CRT), and have heart failure with reduced le... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Aurora St. Luke's Medical Center, Milwaukee, Wisconsin
Conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation
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A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes
NCT05791201
Recruiting
The purpose of the study is to evaluate the safety, tolerability, and efficacy of VX-264 in participants with type 1 diabetes (T1D).
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/05/2024
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Type 1 Diabetes
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(Peak) a Phase 3 Randomized Trial of CGT9486+Sunitinib Vs. Sunitinib in Subjects with Gastrointestinal Stromal Tumors
NCT05208047
Recruiting
This is a Phase 3, open-label, international, multicenter study of CGT9486 in combination with sunitinib. This is a multi-part study that will enroll approximately 442 patients. Part 1 consists of two evaluations: 1) confirming the dose of an updated formulation of CGT9486 to be used in subsequent parts in approximately 20 patients who have received at least one prior line of therapy for GIST and 2) evaluating the potential for drug-drug interactions between CGT9486 and sunitinib in approximatel... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: University of Wisconsin - Carbone Cancer Center, Madison, Wisconsin
Conditions: Advanced Gastrointestinal Stromal Tumors, Metastatic Cancer
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realMIND: Observational Study on Safety and Effectiveness of Tafasitamab in Combination With Lenalidomide in Patients With Relapsed or Refractory DLBCL
NCT04981795
Recruiting
The realMIND study is a multicenter, observational study intended to further characterize the safety and effectiveness data of US patients (with a focus on racial and ethnic minority patients) with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), treated with tafasitamab in combination with lenalidomide.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: Froedtert & Medical College Clinics, Milwaukee, Wisconsin
Conditions: Diffuse Large B-cell Lymphoma
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A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
NCT03887715
Recruiting
Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/05/2024
Locations: University of Wisconsin, Madison, Wisconsin
Conditions: Treatment Resistant Depression
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