There are currently 162 active clinical trials seeking participants for Hypertension research studies. The states with the highest number of trials for Hypertension participants are California, Florida, Texas and Ontario.
Effect of Sublingually Generated S-nitroso-N-acetylcysteine on Systemic Blood Pressure.
NCT05798481
Recruiting
The purpose of the study is to increase the in vivo levels of nitric oxide by generating nitric oxide donor compound S-nitrosoacetylcysteine (SNOAC) using the mixture of sodium nitrite and N-acetylcysteine crystals in the sublingual space. The generated SNOAC rapidly diffuses into blood circulation thereby decrease the systemic blood pressure. This compound can be an alternative to organic nitrate NO donor drugs without developing tolerance in patients.
Gender:
ALL
Ages:
Between 21 years and 80 years
Trial Updated:
04/29/2025
Locations: Anesthesiology and Perioperative Medicine, Birmingham, Alabama
Conditions: Hypertension, Cardiovascular Diseases
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Global Paradise System US Post Approval Study
NCT06297291
Recruiting
The objective of the Global Paradise® System US Post Approval Study (US GPS) is to evaluate the real-world use of the Paradise Ultrasound Renal Denervation System indicated for patients who are unable to lower their blood pressure with lifestyle changes and medication. This system is comprised of a catheter, cable, balloon, and generator and has received FDA approval in the United States. Information collected in this study will be analyzed to better understand the long-term safety and effective... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/29/2025
Locations: Sutter Institute for Medical Research, Sacramento, California +24 locations
Conditions: Hypertension, Cardiovascular Diseases, Vascular Diseases
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Examining Digital Health Care Delivery Models Through Medicaid Collaborative
NCT05555095
Recruiting
The purpose of this study is to examine the intervention effectiveness and dissemination of digital health care delivery models for improving selected health outcomes in the Medicaid population.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/25/2025
Locations: OSF HealthCare System, Peoria, Illinois
Conditions: Hypertension, Diabetes Mellitus, Maternal Health
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Positron Emission Tomography (PET) Imaging of Cholesterol Trafficking: Clinical Evaluation of [18F]FNP-59 in Normal Human Subjects (Groups 2, 3 & 4)
NCT04546126
Recruiting
This study will evaluate the feasibility of using a sub-therapeutic dose of a fluorine-18 analogue of NP-59 (\[18F\]FNP-59) to image the adrenal gland. Some participants are healthy normal subjects but have undergone interventions to manipulate hormones while other participants have known adrenal pathology.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of Michigan, Ann Arbor, Michigan +1 locations
Conditions: Radiotracer, Hypertension, Cholesterol
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Jackson Heart Study Women's Hypertension Study
NCT06511479
Recruiting
High blood pressure is a powerful risk factor for heart disease. Black women are more likely to have high blood pressure than white women or Hispanic women. Even when they are aware they have high blood pressure, many people struggle to keep their blood pressure controlled. Research shows a connection between life stress and high blood pressure and heart disease outcomes. Mindfulness training programs can help people regulate their emotions and cope with stress. Research shows that mindfulness p... Read More
Gender:
FEMALE
Ages:
Between 18 years and 99 years
Trial Updated:
04/23/2025
Locations: University of Mississippi Medical Center, Jackson, Mississippi
Conditions: Hypertension
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Weight Inclusive and Adaptive Strategies to Enhance Cardiometabolic Health in Black Adults
NCT06284681
Recruiting
The proposed 6-month pilot Sequential Multiple Assignment Randomize Trial (SMART) has two aims. The first and primary aim is to determine the feasibility of conducting a full-scale SMART to compare weight-focused (i.e., weight loss) and weight-neutral (i.e., weight loss is not an explicit goal) adaptive biobehavioral interventions for improving cardiometabolic health in Black adults with overweight or obesity (BMI ≥27 kg/m2) plus at least one weight-related cardiometabolic condition (high blood... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/23/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Obesity, Prehypertension, Hypertension, PreDiabetes, Type 2 Diabetes, Dyslipidemia
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How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes
NCT06817252
Recruiting
The goal of this clinical trial is to is to determine the effects of baked potato with the skin (BP) + nutrition education focused on adherence for a Mediterranean Dietary Pattern (MEDNE) on glycemic control, cardiometabolic health, and dietary quality in individuals with pre-diabetes from different demographic backgrounds. The main questions it aims to answer are: * Does BP+MEDNE contribute to improvements in indices of glycemic control, vascular function, blood lipids, inflammation/oxidative... Read More
Gender:
ALL
Ages:
Between 45 years and 80 years
Trial Updated:
04/23/2025
Locations: Department of Kinesiology and Nutrition Sciences, Las Vegas, Nevada +1 locations
Conditions: Prediabetes, Lipid Profile, Hypertension, Glycemic Control, Arterial Stiffness, Blood Pressure, Inflammation Biomarkers, Dietary Quality, Body Composition Measurement, Waist Circumference, Anthropometrics: Height and Weight
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PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
NCT04971720
Recruiting
Obese individuals have a higher prevalence of nocturnal hypertension and non-dipping blood pressure (BP). These conditions are associated with an increased risk of cardiovascular (CV) events and death. Natriuretic Peptides (NPs) are hormones produced by the heart which directly regulate BP by causing dilation of blood vessels and by removing sodium and water from the body. NPs have a 24-hour day-night rhythm and this controls the day-night rhythm of BP as well. The NP-BP rhythm relationship is b... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/21/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama
Conditions: Obesity, Cardiovascular Diseases, Hypertension, Nocturnal Blood Pressure, Natriuretic Peptides, Renin-Angiotensin-Aldosterone System
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Penn Medicine Healthy Heart
NCT06062394
Recruiting
To leverage access to patients across the primary care network, EPIC tools for identifying eligible patients, and the Way to Health platform to launch and enroll a program that will be evaluated in a clinical trial that is focused on changing patient behavior and powered to detect differences in improving blood pressure and cholesterol over 6 months for Penn Medicine patients in West/Southwest Philadelphia and Lancaster.
Gender:
ALL
Ages:
Between 35 years and 80 years
Trial Updated:
04/17/2025
Locations: Penn Medicine, Philadelphia, Pennsylvania
Conditions: Hypertension, Hyperlipidemias
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A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients
NCT03626688
Recruiting
Study ROR-PH-301, ADVANCE OUTCOMES, is designed to assess the efficacy and safety of ralinepag when added to pulmonary arterial hypertension (PAH) standard of care or PAH-specific background therapy in subjects with World Health Organization (WHO) Group 1 PAH.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/17/2025
Locations: University of Alabama at Birmingham, Birmingham, Alabama +213 locations
Conditions: PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension, Connective Tissue Diseases, Familial Primary Pulmonary Hypertension, Vascular Diseases, Cardiovascular Diseases, Hypertension, Pulmonary, Lung Diseases, Respiratory Tract Disease
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Effect of Electro-Acupuncture on Blood Pressure
NCT00932139
Recruiting
Based on previous published research in animals and human, the investigators hypothesize that electroacupuncture (EA) will have a positive effect on hypertension.
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
04/10/2025
Locations: Susan Samueli Integrative Health Institute, Irvine, California +1 locations
Conditions: Hypertension
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Virtual Diabetes Group Visits Across Health Systems
NCT06094491
Recruiting
The purpose of this project is to evaluate the effectiveness of a virtual diabetes group visits on patients with type 2 diabetes mellitus (T2DM).
Gender:
ALL
Ages:
18 years and above
Trial Updated:
04/03/2025
Locations: Access Community Health Network, Chicago, Illinois +1 locations
Conditions: T2DM (Type 2 Diabetes Mellitus), Hypertension, Heart Disease Chronic, Stroke, Hyperlipidemias, Peripheral Vascular Diseases, Obesity
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