Hypertension Clinical Trials

A listing of 160 Hypertension clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas.

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There are currently 160 active clinical trials seeking participants for Hypertension research studies. The states with the highest number of trials for Hypertension participants are California, Florida, Texas and Ontario.

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Recruiting

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Conditions:

Overweight

Overweight and Obesity

Obesity

Weight Loss

Morbid Obesity

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Featured Trial

Paid Clinical Studies Nationwide

Recruiting

Nationwide clinical trials offered in your area. Some trials offering up to several thousand dollars in compensation for participation.

Conditions:

Healthy

Healthy Volunteer Study

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* Compensation for time may be available

Featured Trial

Heart Failure Clinical Trial

Recruiting

You or someone you love may be eligible for a heart failure clinical study. Eligible participants will receive study-related assessments, care, and treatment at no cost. You may be reimbursed for travel while participating. See if you are eligible.

Conditions:

Heart Failure

Congestive Heart Failure

Chronic Heart Failure

Heart Failure

Congestive

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Featured Trial

Obese or Overweight Volunteers Needed for a Research Study

Recruiting

Enroll now in a research study for obese or overweight volunteers with heart disease, hypertension, T2DM, or high cholesterol. All study related assessments are provided at no cost. Compensation up to $125 per visit for qualified participants.

Conditions:

Obesity

Overweight

Overweight and Obesity

Diabetes Mellitus

Type 2

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CARBON: UAB Cardiovascular Research Biobank

NCT05067231

Recruiting

The UAB Cardiovascular Research Biobank (CARBON) will be a resource that contains biological materials, such as DNA samples, in addition to health and personal information on a large number of people over time. It will be set up so that it can be used in the future as a resource for researchers undertaking a wide range of medical research.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

07/01/2025

Locations: University of Alabama at Birmingham, Birmingham, Alabama

Conditions: Natriuretic Peptides, Cardiovascular Diseases, Hypertension, Diabetes, Obesity

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Community Intervention to Reduce CardiovascuLar Disease in Chicago

NCT04755153

Recruiting

Hypertension affects 1 in every 3 adults in the US and contributes to 410,000 deaths annually. Hypertension and its associated complications disproportionately affect minority populations living in urban areas. In Chicago, health status indicators show worsening disparities between black and white residents, with the highest rates of hypertension, heart disease, and stroke clustering in the predominantly black South and West Sides. Kaiser Permanente demonstrated that a bundle of evidence-based interventions implemented within a large, integrated health system in Northern California significantly increased blood pressure control rates. However, it is unclear whether a health system centered intervention can be adapted to other settings, particularly under-resourced urban communities. Therefore, the overall goal is to support a community-centered design and adaptation of the Kaiser bundle. The investigative team will adapt the delivery model of the Kaiser bundle to be centered within churches within the South Side of Chicago, one of the most medically underserved communities in the United States. The proposed interventions are the same as in the Kaiser bundle (e.g., registry/audit and feedback, simplified treatment regimens, accurate Blood Pressure measurement) but implementation of the components of the bundle will be adapted for delivery in the community. The intervention will be carried out by local community health workers and ministry facilitators, with health clinics and hospitals in the community as support, all connected through a common data platform. Thus, the proposed project will identify the best strategies to support adoption, implementation with fidelity, and sustainability of the Kaiser bundle in the community setting. The proposed study will follow the Exploration, Preparation, Implementation and Sustainment (EPIS) process model and implementation is rigorously evaluated using a multimethod approach to the Reach, Effectiveness, Adoption, Implementation, and Maintenance (REAIM) evaluation framework. The specific aims are: Aim 1: Convene community stakeholders in order to adapt implementation strategies using the Dynamic Adaptation Process model. Aim 2: Design, implement, and evaluate pilot projects in order to optimize implementation strategies within the target community. Aim 3: Implement, test and evaluate an adapted implementation strategy to control hypertension through faith-based organizations in the South Side of Chicago. The study uses a hybrid Type 2 effectiveness-implementation design based within one primary community area (South Side Chicago) and in two settings (church and clinic). The overall study outcome is the Public Health Impact metric (reach \* effect size of the intervention). Aim 4: Disseminate findings internally to community stakeholders and externally through creation of community implementation toolkits. Read Less

Gender:

ALL

Ages:

Between 18 years and 89 years

Trial Updated:

07/01/2025

Locations: Pastors4PCOR, Chicago, Illinois +2 locations

Conditions: Hypertension

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A Study to Investigate Tonlamarsen for the Treatment of Adults With Uncontrolled Hypertension

NCT06864104

Recruiting

The purpose of this study is to evaluate the blood pressure-lowering effect of tonlamarsen in adult participants who, despite taking 2 or more antihypertensive medications, have not achieved their target blood pressure (BP).

Gender:

ALL

Ages:

Between 18 years and 80 years

Trial Updated:

06/30/2025

Locations: Pinnacle Research Group, Anniston, Alabama +35 locations

Pinnacle Research Group, Anniston, Alabama

Achieve Clinical Research, LLC, Birmingham, Alabama

Elite Clinical Studies, Phoenix, Arizona

Del Sol Research Management, LLC, Tucson, Arizona

Cardiology and Medicine Clinic, Little Rock, Arkansas

North Coast Cardiology, Encinitas, California

Orange County Research Center, Lake Forest, California

Clinical Trials Research, Lincoln, California

American Institute of Research, Los Angeles, California

Jacksonville Center for Clinical Research, Jacksonville, Florida

Suncoast Clinical Research, Inc., New Port Richey, Florida

Progressive Medical Research, Port Orange, Florida

Agile Clinical Research Trials, LLC, Atlanta, Georgia

Eagle Clinical Research, Chicago, Illinois

Clinical Investigation Specialists, Inc., Gurnee, Illinois

Koch Family Medicine Clinical Research, Morton, Illinois

Tandem Clinical Research GI, LLC, Marrero, Louisiana

IMA Clinical Research, Monroe, Louisiana

DelRicht Clinical Research - New Orleans, New Orleans, Louisiana

ActivMed Practices & Research, LLC, Methuen, Massachusetts

Oakland Medical Research Center, Troy, Michigan

Olive Branch Family Medical Center, Olive Branch, Mississippi

CHEAR Center LLC, Bronx, New York

IMA Clinical Research, Lenoir, North Carolina

Clinical Trials of South Carolina, Moncks Corner, South Carolina

Health Concepts, Rapid City, South Dakota

Holston Medical Group, Kingsport, Tennessee

Central Texas Clinical Research, Austin, Texas

Advanced Medical Trials, LLC, Georgetown, Texas

Juno Research, LLC, Houston, Texas

Radiance Clinical Research, Lampasas, Texas

Synergy Groups Medical, LLC, Missouri City, Texas

North Hills Medical Research, North Richland Hills, Texas

Sun Research Institute, San Antonio, Texas

Manassas Clinical Research Center, Manassas, Virginia

York Clinical Research LLC, Norfolk, Virginia

Conditions: Hypertension

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Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks

NCT03374215

Recruiting

Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium. The cause of these tumors is unknown, but sometimes they are inherited. Objective: To study the genes that may cause primary aldosteronism in Black individuals. Eligibility: People ages 18-70 who: Are Black, African American, or of Caribbean descent And have difficult to control blood pressure or primary aldosteronism Relatives of people with primary aldosteronism Design: Participants who are relatives of people with primary aldosteronism will have only 1 visit, with medical history and blood tests. Participants with primary aldosteronism or difficult to control blood pressure (suspected to possibly have primary aldosteronism) will be screened with a 1-2 hour visit. If they qualify, they will return for a hospital stay for 7-10 days. Tests may include: Medical history Physical exam Blood tests: Participants will have a small tube (IV catheter) inserted in a vein in the arm. They may drink a glucose-containing liquid or get a salt solution. If medically indicated, they may have invasive blood tests with a separate consent. Urine tests: Some require a high-salt diet for 3 days. Heart tests Scans: Participants lie in a machine that takes pictures of the body. A dye may be injected through a vein. Small hair sample taken from near the scalp. Kidney ultrasound Bone density scan: Participants lie on a table while a camera passes over the body. If the doctors feel it is medically necessary, they will offer participants treatment depending on their results. These treatments may cure the patient of their disease and may include: 1. Having one adrenal gland removed by the Endocrine surgeon under anesthesia. Patients will have follow-up visits 2-4 weeks after surgery. 2. Taking drugs to block the effects of aldosterone Participants may return about 1 year later to repeat testing.... Read Less

Gender:

ALL

Ages:

Between 7 years and 70 years

Trial Updated:

06/28/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Adrenal Gland Neoplasm, Hypertension, Bone Diseases, Metabolic, Cardiovascular Disease, Hyperinsulinemia

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BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

NCT06059638

Recruiting

A prospective, multinational, randomized, double-blind, clinical trial evaluating the safety and effectiveness of a novel atrioventricular interval modulation (AVIM) algorithm downloaded into a dual-chamber Medtronic Astra/Azure pacemaker.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/27/2025

Locations: HonorHealth, Scottsdale, Arizona +71 locations

HonorHealth, Scottsdale, Arizona

Stanford, Redwood City, California

Sutter Valley Hospitals, Sacramento, California

Scripps Clinic, San Diego, California

MedStar Washington Hospital Center, Washington, District of Columbia

Clearwater Cardiovascular Consultants, Clearwater, Florida

Citrus Cardiology Consultants, Crystal River, Florida

Memorial Healthcare System, Hollywood, Florida

Baptist Health Jacksonville, Jacksonville, Florida

Mount Sinai Medical Center of Florida, Miami Beach, Florida

Baptist Health South Florida, Miami, Florida

Sarasota Memorial Hospital, Sarasota, Florida

Piedmont Healthcare, Inc., Atlanta, Georgia

University of Chicago, Chicago, Illinois

University of Kansas Medical Center, Kansas City, Kansas

West Houston Area Clinical Trial Consultants (Wichita, KS), Wichita, Kansas

Baptist Health Lexington, Lexington, Kentucky

Ochsner Medical Center, New Orleans, Louisiana

The Johns Hopkins University, Baltimore, Maryland

The Brigham and Women's Hospital, Boston, Massachusetts

St. Elizabeth's Medical Center, Boston, Massachusetts

Michigan Heart, Ypsilanti, Michigan

Mayo Clinic, Rochester, Minnesota

Washington University St. Louis, St. Louis, Missouri

The Cooper Health System, Camden, New Jersey

Hackensack University Medical Center, Hackensack, New Jersey

Virtua Medical Group, P.A., Marlton, New Jersey

The Valley Hospital, Ridgewood, New Jersey

Northwell Health, Inc., New Hyde Park, New York

WakeMed, Raleigh, North Carolina

The Lindner Research Center, Cincinnati, Ohio

The Ohio State University, Columbus, Ohio

OhioHealth Corporation, Columbus, Ohio

South Oklahoma Heart Research, Oklahoma City, Oklahoma

University of Oklahoma, Oklahoma, Oklahoma

Penn Medicine Lancaster General Health, Lancaster, Pennsylvania

Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania

Penn Presbyterian Medical Center, Philadelphia, Pennsylvania

Medical University of South Carolina, Charleston, South Carolina

Stern Cardiovascular Foundation, Inc., Germantown, Tennessee

Ascension St. Thomas Hospital, Nashville, Tennessee

Ascension Seton, Austin, Texas

Baylor Scott & White Research Institute, Dallas, Texas

Advocate Aurora Research Institute, LLC, Milwaukee, Wisconsin

OLV Ziekenhuis, Aalst, Not set

Middelheim Ziekenhuis, Antwerp, Not set

Universite Libre de Bruxelles-Erasme Hospital, Brussels, Not set

UZ Brussel, Brussel, Not set

UZ Leuven, Leuven, Not set

Institute for Clinical and Experimental Medicine (IKEM), Prague, Not set

Na Homolce Hospital, Prague, Not set

Cardioangiologisches Centrum Bethanien (CCB) am AGAPLESION Markus Krankenhaus, Frankfurt, Not set

University Medical Centre Mannheim, Mannheim, Not set

Saarland University Hospital, Saarbrücken, Not set

Krankenhaus der Barmherzigen Brüder Trier, Trier, Not set

Semmelweis University, Budapest, Not set

University of Debrecen, Debrecen, Not set

Amsterdam University Medical Centre, Amsterdam, Not set

Maastricht UMC+, Maastricht, Not set

Jagiellonian University Hospital, Kraków, Not set

Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan, Not set

Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego, Warsaw, Not set

Silesian Center for Heart Diseases, Zabrze, Not set

Hospital Germans Trias i Pujol, Badalona, Not set

Hospital Clínico de Barcelona, Barcelona, Not set

La Paz University Hospital, Madrid, Not set

Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz De Tenerife, Not set

Royal Brompton, London, Not set

St. Bartholomew's Hospital, London, Not set

St. Thomas Hospital, London, Not set

John Radcliffe Hospital, Oxford, Not set

Southampton General Hospital, Southhampton, Not set

Conditions: Hypertension, Hypertension, Systolic, Hypertension, Essential

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Diabetes and Heart Disease Risk in Blacks

NCT00001853

Recruiting

It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to associate obesity with the presence of heart disease risk factors. Risk factors that will be studied include; total body fat, body fat distribution, fat content of the blood (triglyceride concentration, low density lipoproteins \[LDL\], and high density lipoproteins \[HDL\]), how fast fat is removed from the blood, and how well insulin works in the body. Scientific studies have shown that obesity and increased levels of fat content in the blood are important risk factors for heart disease in Caucasian women. However, similar studies in African American women have failed to show the same correlation. In fact, it appears that African American women in all three body weight groupings, nonobese, overweight, and obese experience high death rates due to heart disease. In addition, prior research has shown that obese African American men tend to have elevated levels of fat in the blood while African American women have normal blood fat levels. Therefore, if high levels of triglycerides (fat found in the blood) are not seen in non-diabetic obese African American women, it cannot be considered a risk factor in this population. This suggests that studies conducted on Caucasian women may not provide insight into heart disease risk factors in African American women. The study will take 2000 healthy non-diabetic African American men and women (ages 18-70) and body mass index 3 subgroups; nonobese, overweight and obese. Diabetes undeniably increases the risk of heart disease. Therefore patients suffering from diabetes will not be included in the study. Candidates for the study will undergo a series of tests and examinations over 2 outpatient visits. Subjects will have body fat analyses, resting energy expenditure measurements, an EKG (electrocardiogram), and specific blood tests. Researchers believe this study will provide significant insight into the causes of obesity and heart disease in African Americans. Read Less

Gender:

ALL

Ages:

Between 18 years and 70 years

Trial Updated:

06/27/2025

Locations: National Institutes of Health Clinical Center, Bethesda, Maryland

Conditions: Diabetes, Obesity, Hypertension, Cardiovascular Diseases

Learn More ›

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1

NCT06948435

Recruiting

GZL1 is an independent study conducted under the GZPL master protocol. GZL1 will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight.

Gender:

ALL

Ages:

18 years and above

Trial Updated:

06/26/2025

Locations: Elite Clinical Studies, LLC, Phoenix, Arizona +100 locations

Elite Clinical Studies, LLC, Phoenix, Arizona

Valley Clinical Trials, Inc., Covina, California

Valley Clinical Trials, Inc., Northridge, California

Chase Medical Research, LLC, Waterbury, Connecticut

Excel Medical Clinical Trials, Boca Raton, Florida

Care Access - Brandon, Brandon, Florida

Northeast Research Institute - Downtown Office, Jacksonville, Florida

Peace River Cardiovascular Center, Port Charlotte, Florida

Care Access - Sun City Center - Cypress Village Boulevard, Sun City Center, Florida

East-West Medical Research Institute, Honolulu, Hawaii

Sinai Hospital Of Baltimore, Baltimore, Maryland

Ascension Saint Agnes Heart Care, Baltimore, Maryland

Lucida Clinical Trials, New Bedford, Massachusetts

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division, Troy, Michigan

StudyMetrix Research, Saint Peters, Missouri

Excel Clinical Research, LLC, Las Vegas, Nevada

Palm Research Center Sunset, Las Vegas, Nevada

Rochester Clinical Research, LLC, Rochester, New York

Remington-Davis, Inc, Columbus, Ohio

PriMED Clinical Research, Dayton, Ohio

Advanced Research Institute - Tigard, Tigard, Oregon

Care Access - Mauldin, Mauldin, South Carolina

Dallas Heart and Vascular Consultants, PA, Duncanville, Texas

Texas Institute of Cardiology, PA, McKinney, Texas

North Hills Family Medicine/North Hills Medical Research, North Richland Hills, Texas

Advanced Research Institute, Ogden, Utah

Carient Heart & Vascular - Manassas, Manassas, Virginia

Health Research of Hampton Roads, Inc., Newport News, Virginia

National Clinical Research, Inc, Richmond, Virginia

Eastside Research Associates, Redmond, Washington

Santa Maria de la Salud Centro Medico, San Isidro, Buenos Aires

CIPREC, Buenos Aires, Ciudad Autónoma De Buenos Aires

Centro de Investigaciones Clínicas Baigorria, Granadero Baigorria, Santa Fe

INECO Neurociencias Oroño, Rosario, Santa Fe

Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica, Rosario, Santa Fe

Instituto Médico Especializado (IME), Buenos Aires, Not set

CIPREC, Buenos Aires, Not set

CEMEDIC, Buenos Aires, Not set

Instituto de Investigaciones Clínicas Córdoba, Córdoba, Not set

Beijing Pinggu District Hospital, Beijing, Beijing

The Second Affiliated Hospital of Chongqing Medical University - Yuzhong Campus, Chongqing, Chongqing

The First Affiliated Hospital of Henan University of Science &Technology, Luoyang Shi, Henan

Changde First People's Hospital, Changde, Hunan

Wuxi People's Hospital, Wuxi, Jiangsu

China-Japan Union Hospital, Changchun, Jilin

Siping Central People's Hospital, Siping, Jilin

Shaanxi provincial people's hospital, Xian, Shaanxi

Jinan Central Hospital, Jinan, Shandong

Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai

Sichuan Provincial People's Hospital, Chengdu, Sichuan

Lishui Central Hospital, Lishui City, Zhejiang

Top Moravia Health, Brno, Brno-město

Ordinace Rihackovi, s.r.o., Brno, Brno-město

CTC Hodonin s.r.o., Hodonin, Hodonín

CCR Ostrava s.r.o, Ostrava, Moravskoslezský Kraj

Diahelp s.r.o, Pardubice V, Pardubice

Angiocentrum Komorany, Prague, Praha 12

MUDr. Sarka Drinkova, Ledec nad Sazavou, Vysočina

Clinoxus, Praha 4, Not set

Praglandia s.r.o, Praha 5, Not set

Kardiologische Praxis Dr. med. univ. Wolfgang Jungmair, Bad Homburg, Hessen

Medizentrum Essen Borbeck, Essen, Nordrhein-Westfalen

Zentrum fur klinische Forschung - Köln, Köln, Nordrhein-Westfalen

Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien, Dresden, Sachsen

Universitaetsklinikum Carl Gustav Carus Dresden, Dresden, Sachsen

AmBeNet GmbH, Leipzig, Sachsen

Familienmedizinisches Zentrum Radowsky, Leipzig, Sachsen

RED-Institut GmbH, Oldenburg, Schleswig-Holstein

emovis GmbH, Berlin, Not set

Athens Medical Center - Psychikon branch, Athens, Attikí (Region)

General Hospital of Athens "G. Gennimatas", Athens, Attikí

University Hospital of Ioannina, Ioannina, Ioánnina

G. Gennimatas General Hospital of Thessaloniki, Thessaloniki, Thessaloníki

AHEPA University General Hospital of Thessaloniki, Thessaloniki, Thessaloníki

Papageorgiou General Hospital of Thessaloniki, Thessaloniki, Thessaloníki

G.B. Pant Institute of Postgraduate Medical Education & Research, New Delhi, Delhi

Life Care Hospital and Research Centre, Bangalore, Karnataka

Ashirwad Hospital and Research Centre, Ulhasnagar, Maharashtra

All India Institute of Medical Sciences, Bhubaneswar, Odisha

Mikannohana Clinic, Diabetes, Endocrinology and Metabolism, Matsuyama, Ehime

Takai Internal Medicine Clinic, Kamakura-shi, Kanagawa

Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic, Yamato-shi, Kanagawa

Tokyo-Eki Center-building Clinic, Chuo-ku, Tokyo

Fukuwa Clinic, Chuo-ku, Tokyo

NZOZ Regionalna Poradnia Diabetologiczna, Wroclaw, Dolnośląskie

Centrum Medyczne "Hipokrates" S.C. Elżbieta I Grzegorz Grześk, Bydgoszcz, Kujawsko-pomorskie

NZOZ Centrum Medyczne KERmed, Bydgoszcz, Kujawsko-pomorskie

Balsam Medica, Warsaw, Mazowieckie

Private Practice - Dr. Robert Witek, Tarnów, Małopolskie

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu, Przemysl, Podkarpackie

Uniwersytecki Szpital Kliniczny w Białymstoku, Białystok, Podlaskie

IRMED, Piotrkow Trybunalski, Łódzkie

Dorado Medical Complex, Dorado, Not set

Puerto Rico Medical Research, Ponce, Not set

CHUAC-Complejo Hospitalario Universitario A Coruña, A Coruña, A Coruña [La Coruña]

Hospital San Rafael - La Coruña, La Coruña, A Coruña [La Coruña]

Hospital Quiron Infanta Luisa, Sevilla, Andalucía

EAP Sardenya, Barcelona, Barcelona [Barcelona]

EAP Osona Sud - Alt Congost S.L.P, Centelles, Barcelona [Barcelona]

Complejo Asistencial Universitario de León - Hospital de León, León, Castilla Y León

Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE), Sevilla, Not set

Conditions: Hypertension, Overweight or Obesity

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A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2

NCT06952530

Recruiting

GZL2 is an independent study conducted under the GZPL master protocol. GZL2 study will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight.