There are currently 160 active clinical trials seeking participants for Hypertension research studies. The states with the highest number of trials for Hypertension participants are California, Florida, Texas and Ontario.
A Mobile Health (mHealth) Strategy for Improving Blood Pressure Control Among Adult Hypertensive African Americans
NCT06078540
Recruiting
The purpose of this study is to test the proof-of-concept for adding a novel mHealth application, USeeBP, to the established UChicago Medicine Ambulatory Medicine Remote-Patient Monitoring (UCM-RPM) Hypertension Management Program in a population of African American adults with poorly controlled hypertension.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/23/2025
Locations: University of Chicago, Chicago, Illinois
Conditions: Hypertension, Blood Pressure
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Addressing Barriers to Achieving Cardiometabolic Disorders Prevention and Treatment Goals for PLWH in the SE US
NCT05129345
Recruiting
This study has 3 aims. Aim 1: Identify social determinants of cardiometabolic health and determine facilitators and modifiable barriers in achieving treatment goals. Aim 2: Assess PLWH knowledge, skills, and confidence for self-management of cardiometabolic disorders. Aim 3: Tailor a self-management support and education intervention with stakeholder input to address barriers to achieving treatment goals for cardiometabolic disorders in PLWH at the study sites.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/23/2025
Locations: Duke University - Charlotte Study Sites, Charlotte, North Carolina +1 locations
Conditions: Hypertension, Dyslipidemias, Type 2 Diabetes, HIV-1-infection
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A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2
NCT06952530
Recruiting
GZL2 is an independent study conducted under the GZPL master protocol. GZL2 study will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: Elite Clinical Studies, LLC, Phoenix, Arizona +100 locations
Conditions: Hypertension
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Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women
NCT04439370
Recruiting
This is a cross-sectional study in which the investigators will determine the impact of premature/early menopause on MSNA, BP and baroreflex sensitivity in younger (≤49 yr old) and older (≥50 yr old) women. Specifically, aim one will determine mechanisms driving autonomic dysregulation of BP in premature and early menopausal women and aim two will determine mechanisms driving autonomic dysregulation of BP in older menopausal women. The study design outlined below will permit testing of aim one a... Read More
Gender:
FEMALE
Ages:
Between 35 years and 70 years
Trial Updated:
07/22/2025
Locations: University of Minnesota, Minneapolis, Minnesota
Conditions: Hypertension, Menopause, Premature, Menopause, Blood Pressure
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A Study of LY3971297 in Healthy Participants
NCT06148272
Recruiting
The purpose of this study is to measure side effects of LY3971297 injection administered under the skin in healthy participants and obese participants with high blood pressure (BP). Blood tests will be performed to check how much LY3971297 gets into the bloodstream and how long it takes the body to eliminate it. This is a 7-part study. The study duration will be approximately 60 days for Parts A and F, and approximately 90 days for Parts B, C, D, E, and G.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
07/22/2025
Locations: CenExel ACT, Anaheim, California +5 locations
Conditions: Healthy, Obesity, Hypertension
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A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1
NCT06948435
Recruiting
GZL1 is an independent study conducted under the GZPL master protocol. GZL1 will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: Elite Clinical Studies, LLC, Phoenix, Arizona +100 locations
Conditions: Hypertension, Overweight or Obesity
Register for Updates
A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)
NCT06948422
Recruiting
The GZPL master protocol will support 2 independent studies, J2A-MC-GZL1 (GZL1) and J2A-MC-GZL2 (GZL2). The purpose of this study is to create a framework to evaluate the safety and efficacy of orforglipron for the treatment of hypertension in participants with obesity or overweight.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/22/2025
Locations: Elite Clinical Studies, LLC, Phoenix, Arizona +100 locations
Conditions: Hypertension
Register for Updates
Reach Out 2: Emergency Department-Initiated Hypertension Mobile Health Intervention Connecting Multiple Health Systems
NCT06391073
Recruiting
Emergency department visits provide an opportunity to identify people with undiagnosed, untreated, or uncontrolled high blood pressure. In Reach Out, we will test whether a mobile health intervention yields a greater reduction in blood pressure than usual care among individuals identified with high blood pressure during a safety-net emergency department visit. Subsequently, we will estimate the reduction in heart attack, stroke, and dementia if Reach Out were implemented across all U.S. safety-n... Read More
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
07/21/2025
Locations: Hurley Medical Center, Flint, Michigan
Conditions: Hypertension
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Secondhand Tobacco Smoke and Cardiovascular Disease
NCT04715568
Recruiting
This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary Disease (COPD) due to prolonged exposure to secondhand tobacco smoke.
Gender:
ALL
Ages:
40 years and above
Trial Updated:
07/21/2025
Locations: San Francisco Veterans' Affairs Medical Center, San Francisco, California
Conditions: Cardiovascular Diseases, Hypertension
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Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
NCT06049420
Recruiting
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population. Rural populations are at a particular disadvantage, as they lack access to health clubs, wellness programs and similar resources that are more available in urban areas. Although pharmaceutical therapies have continued to show therapeutic advancements, the rates of disease onset and death from c... Read More
Gender:
ALL
Ages:
Between 18 years and 64 years
Trial Updated:
07/21/2025
Locations: West Virginia School of Osteopathic Medicine, Lewisburg, West Virginia
Conditions: Obesity, Hyperlipidemias, Polycystic Ovary Syndrome, Hypertension, Coronary Heart Disease, Heart Failure, Depression, Anxiety, Type II Diabetes, Metabolic Syndrome
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A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension
NCT06785454
Recruiting
The primary purpose of the study is to assess the effect of lorundrostat taken orally (po) once a day on the Apnea-Hypopnea Index (AHI) in participants with moderate to severe obstructive sleep apnea (OSA) and hypertension.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
07/18/2025
Locations: The University of Alabama, Tuscaloosa, Alabama +26 locations
Conditions: Obstructive Sleep Apnea, Hypertension
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Examining the Feasibility of Implementing a Hypertension Storytelling Intervention Among African Americans
NCT07071077
Recruiting
The purpose of this study is to assess if storytelling is an effective approach for promoting lifestyle and behavioral change among individuals managing hypertension and to determine if storytelling interventions can help to reduce blood pressure and improve medication adherence.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
07/16/2025
Locations: University of Delaware, Newark, Delaware
Conditions: Hypertension
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