Chronobiology of Meal Timing: Effects on Vascular and Renal Function
NCT05987566
Recruiting
The purpose of this study us to investigate the effects of mistimed eating on blood pressure, kidney function and vascular function.
Gender:
All
Ages:
Between 18 years and 45 years
Trial Updated:
09/27/2023
Locations: Virginia Commonwealth Univesity, Richmond, Virginia
Conditions: Hypertension
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Inspiratory Muscle Strength Training in Adults With Type 2 Diabetes
NCT05643768
Recruiting
This clinical research study will investigate the effects of 6 weeks of inspiratory muscle strength training on metabolic and cardiovascular outcomes in adults with recent-onset type 2 diabetes.
Gender:
All
Ages:
Between 18 years and 65 years
Trial Updated:
11/27/2023
Locations: Arizona Respiratory and Neurophysiology Laboratory, Tucson, Arizona
Conditions: Diabetes Mellitus, Type 2, Hypertension
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SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
NCT05198674
Recruiting
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be collected from eligible subjects previously treated in the SPYRAL PIVOTAL-SPYRAL HTN-OFF MED and SPYRAL HTN-ON MED studies.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/24/2023
Locations: University of Alabama at Birmingham (UAB) Hospital, Birmingham, Alabama +57 locations
Conditions: Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases, Diabetes Mellitus
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Diabetes and Heart Disease Risk in Blacks
NCT00001853
Recruiting
It is unknown if obesity contributes to the development of heart disease in African American men and women. This study was created to determine whether there is a relationship between sex and body size and the incidence of heart disease in African American men and women. Researchers will attempt to associate obesity with the presence of heart disease risk factors. Risk factors that will be studied include; total body fat, body fat distribution, fat content of the blood (triglyceride concentrati... Read More
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
11/23/2023
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Diabetes, Obesity, Hypertension, Cardiovascular Diseases
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A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen
NCT05769608
Recruiting
a Phase 2 trial to evaluate the blood pressure-lowering effect of lorundrostat (an aldosterone synthase inhibitor), administered on a background of a standardized anti-hypertensive (AHT) medication regimen, in subjects with uncontrolled and/or treatment-resistant hypertension.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/22/2023
Locations: Cardiology, P.C. - Birmingham, Birmingham, Alabama +67 locations
Conditions: Hypertension
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Open-Label Extension Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Uncontrolled Hypertension
NCT05968430
Recruiting
This study is to evaluate the long-term safety, efficacy and tolerability of lorundrostat (an aldosterone synthase inhibitor) in subjects with uncontrolled hypertension.
Gender:
All
Ages:
18 years and above
Trial Updated:
11/22/2023
Locations: Del Sol Research Management, LLC, Tucson, Arizona +15 locations
Conditions: Hypertension
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Hypertension Chronobiome
NCT03598894
Recruiting
Hypertension is a common condition with a concomitant burden of stroke, kidney disease and myocardial infarction. Its prevalence in developed societies is increasing as they age, and in less developed countries, as their populations assume aspects of the Western diet and lifestyle. Nocturnal non-dipping hypertension (NDHT) - the failure of blood pressure (BP) to dip at night - is estimated to complicate ~40% of hypertensives and is associated with poor outcomes. Randomized controlled trials have... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/21/2023
Locations: Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania, Philadelphia, Pennsylvania
Conditions: Hypertension
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Remote Patient Monitoring and Health Coaching vs. Usual Care for the Treatment of Hypertension
NCT05394766
Recruiting
High blood pressure, also known as hypertension, affects nearly half of all Americans and increases the risk for heart disease and stroke. Only about half of people with high blood pressure have it under control. New methods to control blood pressure are needed to reduce heart attack and stroke rates. The purpose of this study is to test whether a digital program that includes personalized health coaching and remote patient monitoring with a connected blood pressure cuff, all delivered on a smar... Read More
Gender:
All
Ages:
18 years and above
Trial Updated:
11/20/2023
Locations: Stanford University, Redwood City, California
Conditions: Hypertension
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Optimal Blood Pressure Treatment Thresholds Postpartum
NCT06069102
Recruiting
The objective of this research project is to conduct a single-site pilot trial within our institution's clinical remote blood pressures (BP) management program to assess the feasibility and effect of tight blood pressure control versus usual care in the immediate postpartum period after a hypertensive disorder of pregnancy (HDP). The investigators' central hypothesis is that tight blood pressure control will be feasible and acceptable to postpartum individuals and will result in lower BP at six... Read More
Gender:
Female
Ages:
Between 18 years and 55 years
Trial Updated:
11/20/2023
Locations: University of Pittsburgh Magee-Womens Hospital, Pittsburgh, Pennsylvania
Conditions: Hypertensive Disorder of Pregnancy, Pre-Eclampsia, Hypertension, Eclampsia, Gestational Hypertension, Cardiovascular Diseases, Toxemia, Pregnancy Complications, Vascular Diseases, Hypertension, Pregnancy Induced, Hypertension;Pre-Eclamptic
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Grocery Prescription Program for Medicaid Adults With Hypertension or Type 2 Diabetes
NCT06033664
Recruiting
The purpose of this study is to evaluate the effectiveness of a grocery prescription program in adults diagnosed with either Type 2 Diabetes Mellitus or Hypertension. Participants will enroll in Instacart Fresh Funds program. Once enrolled each week participants will select foods that are eligible in the Fresh Funds Program to be delivered to their home for 12 weeks. Participants will also participate in a survey at the beginning of the study and at the end of the study.
Gender:
All
Ages:
Between 18 years and 64 years
Trial Updated:
11/16/2023
Locations: University of Kentucky, Lexington, Kentucky
Conditions: Type 2 Diabetes Mellitus, Hypertension
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Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension
NCT05593055
Recruiting
The investigators' goal is to show that in hypertensive men and women with left ventricular hypertrophy (LVH) treatment with a mineralocorticoid receptor (MR) antagonist, versus a thiazide-like diuretic, will improve coronary microvascular function and cardiac efficiency, which will associate with improvements in LV structure and function. The investigators will achieve this through a randomized, controlled, basic experimental study involving humans (BESH).
Gender:
All
Ages:
Between 18 years and 70 years
Trial Updated:
11/15/2023
Locations: Brigham and Women's Hospital, Boston, Massachusetts
Conditions: Hypertension, Left Ventricular Hypertrophy
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Contributions to Hypertension With Androgen Deprivation Therapy
NCT05700903
Recruiting
This study plans to learn more about contributors to high blood pressure in men who undergo androgen deprivation therapy (ADT) to treat prostate cancer. Prostate cancer is the most common non-skin cancer in men, affecting approximately 1 in 8 American men and its primary treatment is through the use of ADT. However, ADT increases the likelihood of developing heart disease including high blood pressure. This study will determine if dysfunction of the nervous system and/or kidneys occurs in men un... Read More
Gender:
Male
Ages:
40 years and above
Trial Updated:
11/14/2023
Locations: UCHealth University of Colorado Hospital, Aurora, Colorado
Conditions: Androgen Deprivation Therapy, Prostate Cancer, Hypertension, Autonomic Dysfunction, Renal Disease
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