Florida is currently home to 3845 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Miami, Tampa, Jacksonville and Orlando. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis
Recruiting
Adverse outcomes in surgical sepsis patients are secondary to dysregulated emergency myelopoiesis, and expansion of myeloid-derived suppressor cells. Here we propose to determine the underlying mechanisms behind the increased expansion of these leukocyte populations and the underlying mechanisms that drive inflammation and immune suppression.
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/10/2025
Locations: UF Health at Shands hospital, Gainesville, Florida
Conditions: Sepsis, Trauma Injury
Targeted Immunotherapy After Myeloablative TBI-Based Conditioning & AlloHCT in CAYA with High Risk T-Cell ALL & Lymphoma
Recruiting
A Phase I trial to determine the safety of targeted immunotherapy with daratumumab (DARA) IV after total body irradiation (TBI)-based myeloablative conditioning and allogeneic hematopoietic cell transplantation (HCT) for children, adolescents, and young adults (CAYA) with high risk T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LLy). Pre- and post-HCT NGS-MRD studies will be correlated with outcomes in children, adolescents, and young adults with T-ALL undergoin... Read More
Gender:
ALL
Ages:
39 years and below
Trial Updated:
03/10/2025
Locations: University of Florida, Gainsville, Florida
Conditions: T-cell Acute Lymphoblastic Leukemia, T-Cell Acute Lymphoblastic Lymphoma
Computerized Registry of Patients With Venous Thromboembolism (RIETE)
Recruiting
The Computerized Registry of Patients with Venous Thromboembolism (RIETE) is a multidisciplinary Project initiated in march 2001 and consisting in obtaining an extensive data registry of consecutive patients with venous thromboembolism. The main objective is to provide information on the Internet to help physicians to improve their knowledge on the natural history of thromboembolic disease, particularly in those subgroups of patients who are usually not recruited in randomized clinical trials (... Read More
Gender:
ALL
Ages:
All
Trial Updated:
03/10/2025
Locations: College of Medicine - Jacksonville University of Florida, Jacksonville, Florida
Conditions: Venous Thromboembolism
Pediatric Pulmonary Hypertension Network (PPHNet) Informatics Registry
Recruiting
Patients are being asked to be in this research study because medical researchers hope that by gathering information about a large number of children with pulmonary hypertension over time, their understanding of the disease process will increase and lead to better treatment. Investigators believe that pulmonary hypertension in children is different than pulmonary hypertension in adults and this study will help us understand those differences.
Gender:
ALL
Ages:
Between 1 day and 21 years
Trial Updated:
03/10/2025
Locations: Johns Hopkins All Children's Heart Institute, Saint Petersburg, Florida
Conditions: Pulmonary Vascular Disease, Pulmonary Arterial Hypertension
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK202 in Participants with Advanced Solid Tumors
Recruiting
TThis is a first-in-human (FIH), open-label, multicenter dose escalation and expansion study of ALK202. The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and antitumor activity of ALK202 as a monotherapy in adult participants with Advanced Solid Tumors. The study will also identify recommended dose(s) for subsequent clinical studies of ALK202.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/09/2025
Locations: D&H Cancer Research Center Llc, Margate, Florida
Conditions: Advanced Cancer, Advanced Solid Tumor
A Study of LM-24C5 For Advanced Solid Tumors
Recruiting
To assess the safety and tolerability, obtain the recommended phase 2 dose (RP2D)/optimal biologic dose (OBD) and/or Maximum Tolerated Dose (MTD) for LM-24C5 in subjects with advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/08/2025
Locations: Ocala Oncology, Ocala, Florida
Conditions: Advanced Solid Tumor
A Phase 2 Randomized Double-Blind, Parallel, Adaptive-Design, Clinical Trial to Evaluate the Safety and Efficacy of NRCT-101SR with NRCT-202XR Compared to NRCT-202XR Alone in Subjects with Attention-Deficit/Hyperactivity Disorder
Recruiting
A combination therapy of NRCT-101 with NRCT-202 is being developed for patients with ADHD.
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
03/07/2025
Locations: Accel Research Site-Maitland Clinical Research Unit, Maitland, Florida
Conditions: ADHD
OPtilume™ BPH Catheter SystEm for Treatment of Men eXperiencing Symptomatic BPH
Recruiting
APEX is a prospective multi-site registry of real-world experience with the Optilume™ BPH Catheter System for treatment of men experiencing symptomatic BPH.
Gender:
MALE
Ages:
All
Trial Updated:
03/07/2025
Locations: Florida Urology Partners, Tampa, Florida
Conditions: Benign Prostatic Hyperplasia
PTT-936 Alone or in Combination in Patients With Locally Advanced or Metastatic Solid Tumors
Recruiting
This Phase 1/2a study will explore the safety and efficacy of PTT-936, an Alpha Kinase 1 (ALPK1) activator, used alone or in combination with anti-PD-1/L1 therapy in patients with locally advanced or metastatic solid tumors. The study is divided into two parts: Phase 1 (Part A) focuses on determining the pharmaceutically active dosage range and evaluating the safety profile of PTT-936 when administered as a monotherapy. Phase 2a (Part B) will assess the safety and efficacy of PTT-936 combined wi... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/07/2025
Locations: D&H Cancer Research Center, Margate, Florida
Conditions: Locally Advanced or Metastatic Solid Tumors
Study to Evaluate NRCT-101SR in Pediatric Subjects with ADHD
Recruiting
To evaluate the efficacy and safety of NRCT-101SR compared to placebo in subjects 13-17 years of age with ADHD
Gender:
ALL
Ages:
Between 13 years and 17 years
Trial Updated:
03/07/2025
Locations: Accel Research Sites - Lakeland Clinical Research Unit, Lakeland, Florida
Conditions: Attention-Deficit/Hyperactivity Disorder (ADHD)
LEVosimendan to Improve Exercise Limitation in Patients with PH-HFpEF
Recruiting
This study will evaluate the efficacy of TNX-103 (oral levosimendan) compared with placebo in subjects with PH-HFpEF as measured by the change in 6-Minute Walk Distance (6 MWD; Day 1 to Week 12).
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
03/07/2025
Locations: Tenax Investigational Site, Jacksonville, Florida
Conditions: Pulmonary Hypertension
Iberdomide, Daratumumab, Carfilzomib, and Dexamethasone (Iber-KDd) in Patients with Relapsed/Refractory Multiple Myeloma
Recruiting
The investigators want to find out whether or not giving patients who have relapsed or refractory multiple myeloma (MM) the experimental medication combination iberdomide, carfilzomib, daratumumab, and dexamethasone (Iber-KDd) may produce better results than the current (standard of care) treatments. This study will examine the tolerability and efficacy of this combination therapy for all participants and the ability of this combination therapy to shrink or prevent MM from returning.
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
03/07/2025
Locations: University of Miami, Miami, Florida
Conditions: Refractory Multiple Myeloma, Relapsed Multiple Myeloma