Maryland is currently home to 2680 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Efficacy and Safety of Subcutaneous Dupilumab for the Treatment of Adult Participants With Chronic Pruritus of Unknown Origin (CPUO) (LIBERTY-CPUO-CHIC)
NCT05263206
Recruiting
The main objective of the study is to assess efficacy and safety of dupilumab given up to 24 weeks in adults with CPUO. This is a master protocol which includes 2 parallel-treatment, double-blind, 2- arm Phase 3 staggered studies of similar design (Study A and Study B) in male and female participants aged 18 to 90 years with CPUO. Study B design may be adapted based on the results of Study A. For both Study A and B, after an up-to-4-week screening period, participants with severe pruritus (wor... Read More
Gender:
ALL
Ages:
Between 18 years and 90 years
Trial Updated:
03/06/2025
Locations: Johns Hopkins Hospital- Site Number : 8400020, Baltimore, Maryland
Conditions: Pruritus
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A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With Cemiplimab or REGN5678 for Adult Participants With Advanced Prostate Cancer
NCT05125016
Recruiting
This study is researching an investigational drug called REGN4336. Some participants may receive additional investigational drugs in combination with REGN4336. These additional drugs include REGN5678, cemiplimab and sarilumab. The main purpose of this study is to determine the safety, tolerability (how the body reacts to the drug) and effectiveness of REGN4336 alone, in combination with cemiplimab, or in combination with REGN5678. REGN4336, cemiplimab and REGN5678 are a type of treatment for ca... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: University of Maryland Greenebaum Cancer Center, Baltimore, Maryland
Conditions: Metastatic Castration-resistant Prostate Cancer
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An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
NCT05106387
Recruiting
The main purpose of this study is to continue to see how vonsetamig works in the body and to monitor the outcomes after kidney transplant for participants previously treated in the R5459-RT-1944 study (NCT05092347). No study drug will be given during this study.
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/06/2025
Locations: John Hopkins Hospital, Baltimore, Maryland
Conditions: Chronic Kidney Disease (CKD)
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Development of a Wearable Point of Care Monitoring Device for Pediatric Obstructive Sleep Apnea
NCT05052216
Recruiting
Background: Obstructive sleep apnea (OSA) occurs when the blockage of the airway causes a person to stop breathing involuntarily for 10 seconds or more throughout the night during sleep. Pediatric OSA can be especially concerning and can have long-term effects. Researchers want to see how a monitoring device called near-infrared spectroscopy (NIRS) compares with the traditional techniques used in children s sleep studies. Objective: To learn about oxygen levels in the brain and limbs in child... Read More
Gender:
ALL
Ages:
Between 3 years and 12 years
Trial Updated:
03/06/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Pediatric Obstructive Sleep Apnea
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Pragmatic Randomized Clinical Trial to Limit Weight Gain in Pregnancy and Prevent Obesity
NCT04724330
Recruiting
Healthy for Two, Healthy for You (H42/H4U) is an innovative evidence-based pregnancy/postpartum health coach intervention that is remotely-delivered (phone coaching using motivational interviewing, web-based platform, mobile phone behavioral tracking). The aim of this randomized controlled trial (RCT) is to embed H42/H4U into Johns Hopkins prenatal care clinics that serve a racially and economically diverse population, leveraging existing staff as trained health coaches to test its effectiveness... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: Johns Hopkins Health System and University, Baltimore, Maryland
Conditions: Pregnancy Weight Gain, Postpartum Weight Retention, Childhood Obesity, Gestational Diabetes, Overweight and Obesity
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BP1001-A in Patients With Advanced or Recurrent Solid Tumors
NCT04196257
Recruiting
This is a phase I, open-label, study of BP1001-A in participants with advanced or recurrent solid tumors. The dose escalation phase will determine the safety and the maximum tolerated dose (MTD) or maximum administered dose (MAD) of BP1001-A as a single agent. After the MTD or MAD of BP1001-A is established, the dose expansion phase will commence and determine the safety, toxicity and response of BP1001-A in combination with paclitaxel.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: Holy Cross Hospital, Silver Spring, Maryland
Conditions: Solid Tumor, Adult, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms, Endometrial Cancer, Peritoneal Cancer, Solid Tumor
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Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum
NCT04162938
Recruiting
The investigators will conduct a randomized controlled clinical trial study in an urban emergency department in Baltimore to determine the impact of an educational app which is based on Leventhal's Common-Sense Model of Illness Representations framework, on HCV-infected ED patient's hepatitis C virus (HCV) health belief and knowledge as well as the downstream outcomes of the HCV Continuum of Care (linkage to care rate, initiation of HCV antiviral treatment, and sustained virologic response). Fir... Read More
Gender:
ALL
Ages:
Between 18 years and 100 years
Trial Updated:
03/06/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Hepatitis C
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Dose-escalation, Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Patients with R/r NHL and R/r B-cell ALL
NCT03666000
Recruiting
This is a Phase 1/1b, nonrandomized, open-label, parallel assignment, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of azer-cel, an allogeneic anti-CD19 CAR T, in adults with r/r B ALL and r/r B-cell NHL.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/06/2025
Locations: University of Maryland, Baltimore, Maryland
Conditions: Non-Hodgkin Lymphoma, B-cell Acute Lymphoblastic Leukemia
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A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab
NCT02621021
Recruiting
Background: Cell therapy is an experimental cancer therapy. It takes young tumor infiltrating lymphocytes (Young TIL) cells from a person s tumors and grows them in a lab. Then they are returned to the person. Researchers think adding the drug pembrolizumab might make the therapy more effective. Objective: To test if adding pembrolizumab to cell therapy is safe and effective to shrink melanoma tumors. Eligibility: People ages 18-72 years with metastatic melanoma OF THE SKIN Design: Partic... Read More
Gender:
ALL
Ages:
Between 18 years and 72 years
Trial Updated:
03/06/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Melanoma
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Neural and Psychological Mechanisms of Pain Perception
NCT02446262
Recruiting
Background: - Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain. Researchers want to understand how different factors influence pain. They want to test what happens when people expect different levels of pain and receive treatments that can modify pain. They want to see if these factors influence decisions about pain and how the body responds to it. They also want to compare pain with resp... Read More
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
03/06/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Pain, Normal Physiology, Healthy Volunteers
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Reduced Intensity Haploidentical BMT for High Risk Solid Tumors
NCT01804634
Recruiting
The purpose of this study is to see if giving reduced intensity chemotherapy, haploidentical bone marrow, post-transplant cyclophosphamide and shortened duration tacrolimus is safe and feasible for patients with very high-risk solid tumors.
Gender:
ALL
Ages:
Between 1 year and 50 years
Trial Updated:
03/06/2025
Locations: The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland
Conditions: Refractory and/or Relapsed Metastatic Solid Tumors
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Brain and Behavior Influences on Obesity Development From Infancy Through Childhood
NCT06861868
Recruiting
The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity.
Gender:
ALL
Ages:
Between 7 years and 12 years
Trial Updated:
03/05/2025
Locations: Hugo W. Moser Research Institute at Kennedy Krieger, Inc., Baltimore, Maryland
Conditions: Obesity and Overweight
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