Maryland is currently home to 2680 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study)
NCT06847685
Recruiting
The researchers are evaluating mechanisms of uterine fluid absorption during early pregnancy
Gender:
FEMALE
Ages:
Between 18 years and 45 years
Trial Updated:
03/05/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Endometriosis, Endometrioma
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A Study to Evaluate the Efficacy and Safety of Orally Administered VX-01
NCT06770933
Recruiting
The goal of this clinical trial is to evaluate the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of VX-01 as stand-alone treatment for Diabetic Retinopathy of Non-Proliferative Type (NPDR). The primary objective of the study is to evaluate the efficacy of daily oral doses of VX-01 versus placebo following 52 weeks of treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Cumberland Valley Retina Consultants, Hagerstown, Maryland
Conditions: Diabetic Retinopathy, NPDR - Non Proliferative Diabetic Retinopathy
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CROSSOVER STUDY OF ON-DEMAND PREP FORMULATIONS COMPARING RECTAL AND ORAL TENOFOVIR
NCT06560684
Recruiting
This is a Phase 2, multi-site, two-period, open label randomized crossover (Period 1 and 2) study. Participants are randomized 1:1 to one of two 8-week on-demand product sequences - TFV douche then oral F/TDF or oral F/TDF then TFV douche - with a 2 to 4-week washout period in between. Domains of safety, acceptability, adherence, and PK/PD (sub-study only) are assessed for each product.
Gender:
MALE
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Johns Hopkins University CRS, Baltimore, Maryland
Conditions: Tenofovir
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The Protrieve PROTECTOR Study
NCT06495996
Recruiting
The Protrieve PROTECTOR Study is a prospective, single-arm, multicenter study of the Protrieve Sheath.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: MedStar Union Memorial Hospital, Baltimore, Maryland
Conditions: Venous Thromboembolism, Deep Venous Thrombosis
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Access MeMed BV Assay Clinical Study Collection Protocol - Infectious Adult and Pediatric Cohorts
NCT06379061
Recruiting
The purpose of the pivotal study is to collect blood specimens and clinical data from pediatric (\>90 days old) and adult (≥18 years old) patients presenting with signs and symptoms suggestive of acute bacterial or viral infection. These samples will be used to establish the diagnostic performance of MeMed BV™ for differentiating bacterial from viral infection using method comparison and/or method concordance.
Gender:
ALL
Ages:
Between 90 days and 89 years
Trial Updated:
03/05/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Infection, Bacterial, Infection Viral
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Cognitive Behavioral Therapy for Chronic Pain in Adults with Cerebral Palsy
NCT06269926
Recruiting
The purpose of this study is to understand if cognitive behavioral therapy can feasibly be provided to groups of adults with cerebral palsy and chronic pain via virtual group therapy sessions.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Cerebral Palsy, Pain, Chronic
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A Study of NPX887 for Participants With Solid Tumors Known to Express B7-H7/HHLA2
NCT06240728
Recruiting
NPX887 is a human, antagonistic immunoglobulin G1 (IgG1) monoclonal antibody targeting B7-H7 (HHLA2) that may potentiate an anti-tumor immune response. The goal of this first-in-human study is to learn whether NPX887 is safe and tolerable and shows a preliminary efficacy in participants with B7-H7 (HHLA2) expressing tumors at selected dose(s). The main questions it aims to answer are: * what is an appropriate dose to be given to participants? * are the side effects of treatment manageable? * wh... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Conditions: Metastatic Malignant Neoplasm
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Efficacy and Safety Studies of Frexalimab (SAR441344) in Adults With Relapsing Forms of Multiple Sclerosis
NCT06141473
Recruiting
The purpose of each study is to independently measure the annualized relapse rate (ARR) with administration of frexalimab compared to a daily oral dose of teriflunomide in male and female participants with relapsing forms of multiple sclerosis (aged 18 to 55 years at the time of enrollment). People diagnosed with relapsing forms of multiple sclerosis are eligible for enrollment as long as they meet all the inclusion criteria and none of the exclusion criteria. Study details include: * This eve... Read More
Gender:
ALL
Ages:
Between 18 years and 55 years
Trial Updated:
03/05/2025
Locations: International Neurorehabilitation Institute- Site Number : 8400089, Lutherville, Maryland
Conditions: Multiple Sclerosis
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A Study to Evaluate the Safety and Effectiveness Transdermal Compress Device in Participants with Transfemoral Amputations
NCT06134167
Recruiting
The purpose of this study is to evaluate the safety and effectiveness of the Transdermal Compress device in participants with Transfemoral Amputations.
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/05/2025
Locations: The Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Prosthesis and Implants
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DINO RCT - Treating Anxiety in Children with Autism
NCT06066983
Recruiting
Anxiety is prevalent in young children, under 7 years of age, with autism. Yet, few studies have examined anxiety interventions for this age range, and only one anxiety treatment study has included young children with cognitive and language delays. Anxiety treatment models utilizing cognitive-behavioral therapy (CBT), adapted for children with autism, are empirically supported in school-age autistic children. Further, preliminary evidence suggests CBT approaches may reduce intolerance of uncerta... Read More
Gender:
ALL
Ages:
Between 4 years and 6 years
Trial Updated:
03/05/2025
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Autism Spectrum Disorder, Anxiety Disorders
Register for Updates
A Study of NPX267 for Subjects With Solid Tumors Known to Express HHLA2/B7-H7
NCT05958199
Recruiting
NPX267 is an antibody drug targeting the inhibitory receptor for B7-H7 (HHLA2) which may control evasion of the immune response in tumors. The goal of this clinical trial is to learn whether NPX267 is safe and tolerable in patients whose cancers are known to express HHLA2 including epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer. The main questions it aims to answer are: * what is an appropriate dose to be given to patients? * are the side effects of treatment manageab... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/05/2025
Locations: Johns Hopkins University Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland
Conditions: Metastatic Malignant Neoplasm
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A Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis
NCT05890729
Recruiting
A phase 1b/2 study of XTMAB-16 in patients with pulmonary sarcoidosis
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
03/05/2025
Locations: Xentria Investigative Site, Baltimore, Maryland
Conditions: Pulmonary Sarcoidosis
Register for Updates