Maryland is currently home to 2674 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Lurbinectedin With or Without Avelumab in Small Cell Carcinoma of the Bladder (LASER)
NCT06228066
Recruiting
Background: Small cell carcinoma of the bladder (SCCB) and other high-grade neuroendocrine tumors (HGNET) of the urinary tract are rare but aggressive cancers. Average survival for people diagnosed with SCCB or HGNET is about 1 year. Lurbinectedin and avelumab are drugs that are approved to treat other cancers. Researchers want to see if these drugs can help people with SCCB or HGNET. Objective: To test lurbinectedin with or without avelumab in people with SCCB or HGNET. Eligibility: Adults... Read More
Gender:
ALL
Ages:
Between 18 years and 120 years
Trial Updated:
01/03/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Small Cell Carcinoma of the Bladder, High Grade Neuroendocrine Tumors of the Urinary Tract
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Treating Polysubstance Use Using a Novel Digital Technology
NCT05766631
Recruiting
The goal of this clinical trial is to determine the effects of an app to reduce opioid and cocaine use when layered atop methadone treatment as usual among people using both opioids and cocaine. The main questions it aims to answer are: * Do people who use the app remain in methadone treatment longer than people who receive only treatment as usual? * Do people who use the app report using opioids and/or cocaine less often, and do they report better improvements in their quality of life, than pe... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/03/2025
Locations: Friends Research Institute, Inc. Central Office, Baltimore, Maryland
Conditions: Opioid Use, Opioid Use Disorder, Cocaine Use, Cocaine Use Disorder
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Economic Incentives and vDOT for Latent Tuberculosis Infection
NCT05022862
Recruiting
The purpose of this study is to evaluate a novel and scalable intervention that combines Video Directly Observed Therapy (vDOT) and financial incentives to promote completion of treatment for latent tuberculosis. Adult participants who are initiating treatment for latent tuberculosis will be recruited from the Baltimore City Health Department. The primary hypothesis is that the incentive intervention will increase the percentage of participants that complete the treatment for latent tuberculosis... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/03/2025
Locations: Baltimore City Health Department, and Baltimore metropolitan area clinics and health departments, Baltimore, Maryland
Conditions: Latent Tuberculosis
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Sequential Testosterone and Enzalutamide Prevents Unfavorable Progression
NCT04363164
Recruiting
Asymptomatic men without pain due to prostate cancer progressing with metastatic CRPC after treatment with combination or sequential ADT + Abi will be treated on a randomized, open label study to determine if sequential treatment with high dose T and Enza will improve primary and secondary objectives vs. continuous Enza as standard therapy.
Gender:
MALE
Ages:
Between 18 years and 90 years
Trial Updated:
01/03/2025
Locations: Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland
Conditions: Castration Resistant Metastatic Prostate Cancer
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Metformin IN Asthma for Overweight and Obese Individuals (MINA)
NCT06273072
Recruiting
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/02/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Asthma, Asthma Chronic, Overweight and Obesity
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The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry
NCT06030063
Recruiting
The SOAP registry is a prospective, multicenter, electronic registry. The goal is to investigate the indications, mode of airway management, predisposing factors, and obstetric and anesthetic outcomes of pregnant patients who receive general anesthesia for cesarean delivery.
Gender:
FEMALE
Ages:
Between 15 years and 55 years
Trial Updated:
01/02/2025
Locations: University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Cesarean Delivery, General Anesthesia
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Evaluating Buspirone to Treat Opioid Withdrawal
NCT05511909
Recruiting
The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of buspirone for both withdrawal and craving among individuals with opioid use disorder (OUD) undergoing a standardized stepwise taper. During this 10 to 12-day residential study, participants with OUD will be enrolled, stabilized on a short-acting opioid, undergo an opioid stepwise taper, and complete a post-taper observation period where partic... Read More
Gender:
ALL
Ages:
Between 18 years and 75 years
Trial Updated:
01/02/2025
Locations: Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Opioid Use Disorder, Opioid Withdrawal, Opioid Craving, Anxiety
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Transcranial Direct Current Stimulation in the Treatment of Primary Progressive Aphasia
NCT05386394
Recruiting
While many have strongly suggested that transcranial direct current stimulation (tDCS) may represent a beneficial intervention for patients with primary progressive aphasia (PPA), this promising technology has not yet been applied widely in clinical settings. This treatment gap is underscored by the absence of any neurally-focused standard-of-care treatments to mitigate the devastating impact of aphasia on patients' family, work, and social lives. Given that tDCS is inexpensive, easy to use (it... Read More
Gender:
ALL
Ages:
Between 50 years and 80 years
Trial Updated:
01/02/2025
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Primary Progressive Aphasia, Logopenic Progressive Aphasia, Non-Fluent Primary Progressive Aphasia
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Real-Time Feedback (RTFB) to Improve Colonoscopy
NCT05241210
Recruiting
To test whether real-time feedback will improve quality of endoscopic examination.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/02/2025
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Colorectal Cancer
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Study of Cretostimogene Given in Patients With Non-Muscle Invasive Bladder Cancer ,Unresponsive to Bacillus-Calmette-Guerin
NCT04452591
Recruiting
This is a Phase 3, open-label, single arm trial designed to evaluate Cretostimogene patients with NMIBC who have failed prior BCG therapy. Up to approximately 115 CIS bladder cancer patients with or without HG Ta or HG T1 papillary disease will be enrolled under the original protocol through Amendment 4, which will comprise Cohort C. Cohort C is closed to enrollment. Under Amendment 5-1, Cohort P was added to enroll up to 70 patients with HG Ta/T1 papillary bladder cancer. Under Amendment 6, t... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
01/02/2025
Locations: Chesapeake Urology, Severna Park, Maryland
Conditions: Non Muscle Invasive Bladder Cancer, High-grade Ta/ T1 Papillary Disease Bladder Cancer
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Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer
NCT06253520
Recruiting
Background: Many cancer cells produce substances called antigens that are unique to each cancer. These antigens stimulate the body s immune responses. One approach to treating these cancers is to take disease-fighting white blood cells from a person, change those cells so they will target the specific proteins (called antigens) from the cancer cells, and return them to that person s blood. The use of the white blood cells in this manner is one form of gene therapy. A vaccine may help these modi... Read More
Gender:
ALL
Ages:
Between 18 years and 72 years
Trial Updated:
12/31/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Metastatic Solid Cancers, Colorectal Cancer, Breast Cancer, Non-Small Cell Lung Cancer, Gastrointestinal Cancer, Ovarian Cancer, Genitourinary Cancer
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A Clinical Observational Study of SARS-CoV-2 Specific CD8 T-Cell Responses to COVID-19 Vaccines in Humans
NCT04852289
Recruiting
Background: The immune response is how the body recognizes and defends itself against foreign and harmful substances. Researchers want to compare the immune responses between young and older healthy adults after they receive vaccine doses for COVID-19. This research may help to determine whether age impacts cell response to COVID-19 vaccines. Objective: To study the immune response of people who receive Pizer or Moderna COVID-19 vaccines. Eligibility: People aged 18 and older who have not h... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/31/2024
Locations: National Institute of Aging, Clinical Research Unit, Baltimore, Maryland
Conditions: COVID-19
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