Maryland is currently home to 2681 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
NCT00271180
Recruiting
The main purpose of the Product Performance Report (formerly referred to as System Longevity Study) is to evaluate long-term performance of Medtronic market-released cardiac rhythm products by analyzing product survival probabilities.
Gender:
ALL
Ages:
All
Trial Updated:
12/23/2024
Locations: Not set, Baltimore, Maryland
Conditions: Arrhythmia, Bradycardia, Heart Failure, Sinus Tachycardia
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Investigational Use of Neuromuscular Ultrasound
NCT05237973
Recruiting
Background: Current techniques used to measure the health and function of a person s nerves and muscles are generally effective, but they do have limits. Researchers are looking for ways to improve the ability to observe nerves and muscles and how they function in this natural history protocol. Objective: To study the use of ultrasound (sound waves) to learn more about nerves and muscles. Eligibility: Healthy adults, aged 18 and older, with no history of stroke, nerve or muscular disorders,... Read More
Gender:
ALL
Ages:
Between 18 years and 110 years
Trial Updated:
12/21/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Muscular Dystrophy, Peripheral Neuropathy, Motor Neuron Disorder, Normal Physiology
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Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body
NCT06470243
Recruiting
This phase III trial compares the effect of adding carboplatin to the standard of care chemotherapy drug cabazitaxel versus cabazitaxel alone in treating prostate cancer that keeps growing even when the amount of testosterone in the body is reduced to very low levels (castrate-resistant) and that has spread from where it first started (primary site) to other places in the body (metastatic). Carboplatin is in a class of medications known as platinum-containing compounds. Carboplatin works by kill... Read More
Gender:
MALE
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Christiana Care - Union Hospital, Elkton, Maryland
Conditions: Castration-Resistant Prostate Carcinoma, Stage IVB Prostate Cancer AJCC v8
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Study to Compare Axicabtagene Ciloleucel With Standard of Care Therapy as First-line Treatment in Participants With High-risk Large B-cell Lymphoma
NCT05605899
Recruiting
The goal of this clinical study is to compare the study drug, axicabtagene ciloleucel, versus standard of care (SOC) in first-line therapy in participants with high-risk large B-cell lymphoma.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: University of MD Greenebaum Comprehensive Cancer Center, Baltimore, Maryland
Conditions: High-risk Large B-cell Lymphoma (LBCL)
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Patient-Reported Erectile Recovery and Quality of Life Outcomes With Lyopreserved Placental Tissue Applied Directly Over Neurovascular Bundle During Nerve Sparing Radical Prostatectomy Versus Standard of Care
NCT05366842
Recruiting
Surgical implantation of Lyopreserved Placental Tissue (LPT) is FDA approved and has been used extensively in wound care. The use is expanding and more recently, LPT has been used in the management of diabetic foot ulcers, acute and chronic surgical wounds, various fistulas and even as a nerve wrap on the common peroneal nerve. Surgical technique for nerve-sparing prostatectomy has evolved continuously since first described by Walsh in 1982 and is now commonly performed with robotic assistance.... Read More
Gender:
MALE
Ages:
Between 40 years and 65 years
Trial Updated:
12/20/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Prostate Cancer
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The ENCIRCLE Trial
NCT04153292
Recruiting
This study will establish the safety and effectiveness of the SAPIEN M3 System in subjects with symptomatic, at least 3+ mitral regurgitation (MR) for whom commercially available surgical or transcatheter treatment options are deemed unsuitable. Following completion of enrollment, subjects will be eligible for enrollment in the continued access phase of the trial.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/20/2024
Locations: Medstar Union Memorial Hospital, Baltimore, Maryland
Conditions: Mitral Regurgitation, Mitral Valve Insufficiency
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Transforming Robot-mediated Telerehabilitation: Citizen Science for Rehabilitation
NCT03096262
Recruiting
The purpose of this study is to advance upper limb robot-mediated tele-rehabilitation for patients recovering from stroke by empowering them through active science participation. By varying the tasks' features and affordances of a platform that combines a low-cost haptic device on one hand, and an online citizen science platform on the other, investigators will evaluate different strategies for social telerehabilitation. the two fundamental modes of social interaction - competition and cooperati... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
12/20/2024
Locations: Matthew Bird, Baltimore, Maryland
Conditions: Hemiparesis, Stroke
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Study of Navtemadlin Add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients with Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib
NCT06479135
Recruiting
This clinical trial is evaluating whether addition of navtemadlin to ruxolitinib treatment will provide more clinical benefit than ruxolitinib alone for patients with Myelofibrosis who have a suboptimal response to ruxolitinib treatment alone. Subjects will start by receiving ruxolitinib alone in the run-in period. Those who demostrate a suboptimal response from ruxolitinib alone will then be randomized 2:1 to receive navtemadlin or navtemadlin placebo as add-on treatment to their ongoing ruxol... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: The Center for Cancer and Blood Disorders, Bethesda, Maryland
Conditions: Myelofibrosis, Post-PV MF, Post-ET Myelofibrosis, Primary Myelofibrosis, MF
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Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma
NCT06307665
Recruiting
The purpose of this study is to compare the effect of budesonide/albuterol metered-dose inhaler (BDA MDI) with albuterol sulfate metered-dose inhaler (AS MDI), both administered as needed, on the annualized rate of severe asthma exacerbations in adolescents with a documented clinical diagnosis of asthma and at least one severe exacerbation in the prior year.
Gender:
ALL
Ages:
Between 12 years and 17 years
Trial Updated:
12/19/2024
Locations: Research Site, Silver Spring, Maryland
Conditions: Asthma
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Surface Electrical Stimulation for Urinary Incontinence in Men Treated for Prostate Cancer
NCT06161506
Recruiting
Background: Men who are treated for prostate cancer often develop urinary leakage (incontinence). An experimental device that uses electrical impulses to stimulate pelvic floor muscles and surrounding tissues may help. Objective: To see if the Elidah device can reduce urinary incontinence after prostate treatment. Eligibility: Men aged 18 years and older who have had moderate urinary incontinence for at least 6 months after treatment for prostate cancer. Design: Participants will be in th... Read More
Gender:
MALE
Ages:
Between 18 years and 120 years
Trial Updated:
12/19/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Urinary Urge Incontinence, Stress Urinary Incontinence, Prostatic Hyperplasia
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Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)
NCT06135870
Recruiting
The investigators are evaluating the role of senescent cells in uterine fibroids.
Gender:
FEMALE
Ages:
Between 18 years and 55 years
Trial Updated:
12/19/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Fibroid, Leiomyoma
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Outpatient Administration of Teclistamab or Talquetamab for Multiple Myeloma
NCT05972135
Recruiting
This is a phase II study to evaluate the outpatient administration of Teclistamab or Talquetamab in Multiple Myeloma patients
Gender:
ALL
Ages:
18 years and above
Trial Updated:
12/19/2024
Locations: Maryland Oncology Hematology, Columbia, Maryland
Conditions: Multiple Myeloma
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