Maryland is currently home to 2668 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
RRx-001 for Reducing Oral Mucositis in Patients Receiving Chemotherapy and Radiation for Head and Neck Cancer
NCT05966194
Recruiting
The purpose of this study is to determine if RRx-001, which is added on to the cisplatin and radiation treatment, reduces the incidence of severe oral mucositis in patients with head and neck cancers. All patients in this study will receive 7 weeks of standard of care radiation therapy given with the chemotherapy agent, cisplatin. Patients will receive RRx-001 or placebo before start of standard of care treatment.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Sandra and Malcolm Berman Cancer Institute, Baltimore, Maryland
Conditions: Oral Mucositis
Register for Updates
Incremental Hemodialysis: The TwoPlus Trial
NCT05828823
Recruiting
This study is to prospectively compare clinical effectiveness between clinically- matched incremental hemodialysis and conventional hemodialysis in patients with incident kidney dysfunction requiring dialysis and residual kidney function. The study will enroll 350 patients on chronic hemodialysis and 140 caregivers of enrolled patients. Patients will be randomized in 1:1 ratio to either incremental start hemodialysis or conventional hemodialysis. Caregivers will be followed along with patients... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Johns Hopkins University School of Medicine (JHUSM), Baltimore, Maryland
Conditions: End-Stage Kidney Disease
Register for Updates
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
NCT05379985
Recruiting
Evaluate the safety and tolerability of RMC-6236 in adults with specific RAS mutant advanced solid tumors.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumors
Register for Updates
Safety and Efficacy of Allogeneic HPV-specific T Cells in Adults With Recurrent or Metastatic HPV16+ Cancers
NCT04713046
Recruiting
In this study, haploidentical relatives of a patient with recurrent or metastatic HPV 16-associated malignancy will be vaccinated with a therapeutic human papillomavirus (HPV) vaccine series to generate HPV-specific leukocytes. The cancer patient with recurrent or metastatic HPV16+ cancer will then be randomized to one of two arms: 1) non-myeloablative allogeneic bone marrow transplant or 2) cluster of differentiation 8 (CD8)-depleted donor lymphocyte infusion.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/12/2024
Locations: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland
Conditions: HPV 16+ Recurrent or Metastatic Cancer
Register for Updates
Hybrid Robot+FES Stroke Rehabilitation
NCT04550728
Recruiting
The investigators have developed a novel robot-guided stretching under intelligent control and combine it with active movement training, which helped increase joint ROM, reduce spasticity and joint stiffness, increase muscle force output, and improve locomotion. However, for stroke survivors with sensorimotor impairment, their peripheral muscle may not sufficiently be recruited. Functional electrical stimulation (FES), has been shown its advantage to activate the peripheral muscles for people wi... Read More
Gender:
ALL
Ages:
Between 18 years and 85 years
Trial Updated:
11/12/2024
Locations: University of Maryland School of Medicine, Baltimore, Maryland
Conditions: Stroke
Register for Updates
Nerve Transfer to Improve Function in High Level Tetraplegia
NCT06288763
Recruiting
The goal of this observational study is to determine if nerve transfer surgeries improve upper extremity function and quality of life in patients with a high level cervical spinal cord injury. Participants will: * undergo standard of care pre- and post-op testing and study exams * complete pre- and post-questionnaires * undergo standard of care nerve transfer surgeries * follow-up with surgeon at 6/12/18/24/36 and potentially at 48 months * attend therapy at local therapist for up to 2 years p... Read More
Gender:
ALL
Ages:
Between 18 years and 80 years
Trial Updated:
11/11/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Cervical Spinal Cord Injury, Tetraplegia
Register for Updates
Psilocybin-assisted Treatment for Cannabis Use Disorder
NCT06660381
Recruiting
This pilot study will evaluate the therapeutic potential of psilocybin in people with Cannabis Use Disorder (CUD). This study will examine the impact of psilocybin treatment on cannabis use and related variables in 12 people with CUD. This is an open-label proof-of-concept trial in which participants will complete a 12-week course of study treatment including two psilocybin sessions with psychological support, and follow-up assessments 3 and 6 months after the first psilocybin session.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Johns Hopkins Center for Psychedelic and Consciousness Research, Baltimore, Maryland
Conditions: Cannabis Use Disorder
Register for Updates
Leniolisib for Immune Dysregulation in PIDs
NCT06549114
Recruiting
This study is an exploratory, non-randomized, open-label, within-patient dose escalation study. The primary objective is to assess safety and tolerability of leniolisib. Secondary objectives include assessments of PK/PD, and to explore clinical efficacy measures with administration of three different dose levels of leniolisib.
Gender:
ALL
Ages:
Between 12 years and 75 years
Trial Updated:
11/08/2024
Locations: National Institute of Health, Bethesda, Maryland
Conditions: Primary Immunodeficiency Disorders (PIDs)
Register for Updates
Connecting Friends and Health Workers to Boost COVID-19 Vaccination in Latino Communities
NCT06128928
Recruiting
The goal of this clinical trial is to find out which approach works better in getting more of the friends and connections of Latino adults get vaccinated against COVID-19. The main questions this study aims to answer are: 1. Can teaching people to use motivational interviewing help more friends and connections of Latino adults get the COVID-19 vaccine compared to just giving information about the vaccine? 2. What are the things that make it easier or harder for Latinos and networks to get the... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: COVID-19, Vaccine
Register for Updates
Estrogen Supplementation and Bone Health in Women With CF
NCT05704036
Recruiting
The goal of this study is to learn about the role of estrogen and other hormones in bone development in adolescent and young adult women with cystic fibrosis (CF). The study has two main components, an observational study and a feasibility sub-study. The main questions it aims to answer are: * How do different forms of hormonal contraception (e.g. birth control pill or other progesterone only methods) impact bone health? * Is a study of transdermal estradiol (estrogen skin patches) feasible in... Read More
Gender:
FEMALE
Ages:
Between 0 years and 100 years
Trial Updated:
11/08/2024
Locations: Johns Hopkins, Baltimore, Maryland
Conditions: Cystic Fibrosis, Hypoestrogenism
Register for Updates
Tamibarotene Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome
NCT04797780
Recruiting
This study compares the efficacy of Tamibarotene in combination with azacitidine to azacitidine in combination with placebo in participants who are Retinoic Acid Receptor Alpha (RARA) positive, and newly diagnosed with higher-risk myelodysplastic syndrome (HR-MDS), and who have not received treatment for this diagnosis. The primary goal of the study is to compare the complete remission rate between the two treatment arms.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
11/08/2024
Locations: Johns Hopkins University, Baltimore, Maryland
Conditions: Myelodysplastic Syndromes
Register for Updates
Escitalopram and Language Intervention for Subacute Aphasia
NCT03843463
Recruiting
In this project, the investigators will investigate the effects of a selective serotonin reuptake inhibitor (SSRI), escitalopram, on augmenting language therapy effectiveness, as measured by naming untrained pictures and describing pictures, in individuals with aphasia in the acute and subacute post stroke period (i.e., within three months post stroke).
Gender:
ALL
Ages:
Between 18 years and 99 years
Trial Updated:
11/08/2024
Locations: Johns Hopkins School of Medicine, Baltimore, Maryland
Conditions: Aphasia, Stroke
Register for Updates