Maryland is currently home to 2668 active clinical trials, seeking participants for engagement in research studies. These trials take place at a variety of cities in the state, including Baltimore, Bethesda, Rockville and Annapolis. Whether you're a healthy volunteer interested in paid medical research or someone seeking trials related to a specific condition, the state offers a diverse array of opportunities in your vicinity.
Behavioral Assessment and Treatment of Problem Behavior in Children With Cornelia de Lange Syndrome
NCT05829668
Recruiting
The goals of this clinical trial are to identify factors associated with the development of problem behavior in Cornelia de Lange syndrome (CdLS) and to develop an effective behavioral assessment and treatment model for problem behavior in children with CdLS. The hypotheses are as follows: 1. Based on pilot data, the investigators hypothesize that individuals with CdLS will exhibit preferences for auditory stimuli relative to other categories (e.g., visual, tactile) of stimuli. 2. Based on pil... Read More
Gender:
ALL
Ages:
Between 3 years and 15 years
Trial Updated:
10/08/2024
Locations: Kennedy Krieger Institute, Baltimore, Maryland
Conditions: Cornelia de Lange Syndrome
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Open Versus Arthroscopic Stabilization of Shoulder Instability with Subcritical Bone Loss: the OASIS Trial
NCT04809064
Recruiting
This clinical trial will investigate the effects of three surgical procedures and the associated post-operative rehabilitation to optimize time to return to military duty, work and sports, and patient-reported physical function for military personnel and civilians with traumatic anterior shoulder instability and 10-20% glenoid bone loss.
Gender:
ALL
Ages:
Between 17 years and 50 years
Trial Updated:
10/08/2024
Locations: US Naval Health Clinic (Academy), Annapolis, Maryland
Conditions: Shoulder Dislocation, Glenohumeral Dislocation, Anterior Shoulder Dislocation
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Exercise and Nutrition Interventions During Chemotherapy K07
NCT03858153
Recruiting
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and severe side-effect of taxane chemotherapy, often used to treat breast cancer. Unfortunately there are very limited treatments for CIPN. This is a phase II randomized controlled trial to test the preliminary efficacy of exercise vs. nutrition education on CIPN, to systematically investigate the potential roles of inflammation and interoception, and to obtain data with a more accurate effect size to inform a future study.
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/08/2024
Locations: University of Maryland, Baltimore, Maryland
Conditions: Neuropathy;Peripheral
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Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
NCT03295981
Recruiting
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/07/2024
Locations: Johns Hopkins University Hospital, Baltimore, Maryland
Conditions: Giant Cell Tumor of Bone
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Fetoscopic Endoluminal Tracheal Occlusion (FETO) for Severe Left Diaphragmatic Hernia (CDH)
NCT02710968
Recruiting
Despite advances in prenatal diagnosis and postnatal therapies, including extracorporeal membrane oxygenation (ECMO), inhaled nitric oxide therapy, and ventilator strategies that minimize ventilator-induced lung injury, morbidity and mortality rates for babies with congenital diaphragmatic hernia (CDH) remain high. The survival relates to the degree of prenatal lung compression and the subsequent impairment of pulmonary function following delivery. Prenatal assessment by ultrasound or magnetic r... Read More
Gender:
FEMALE
Ages:
18 years and above
Trial Updated:
10/04/2024
Locations: Johns Hopkins Center for Fetal Therapy, Baltimore, Maryland
Conditions: Congenital Diaphragmatic Hernia
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Detection and Characterization of Neurologic Manifestations of Inborn and Acquired Errors of Immunity
NCT06169150
Recruiting
Background: Immune system and nervous system have significant interaction so that People with immunity diseases can have complications that affect the nervous system and people with some neurological disease may have defects in their immune system.These complications can affect many body functions, including how they move, walk, think, and feel. Researchers do not fully understand how immune diseases affect the nervous system. By learning more, they hope to create more effective treatments. Ob... Read More
Gender:
ALL
Ages:
Between 2 years and 120 years
Trial Updated:
10/03/2024
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Nervous System Disease, Immune System Disease
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Comparing Use of Incentive Spirometry with and Without Reminder
NCT06101030
Recruiting
This study is designed to determine if patients using an incentive spirometer with visual and auditory signals will increase their use of the incentive spirometer and prevent lung complications.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Tidal Reseach Site, Silver Spring, Maryland
Conditions: Post Operative
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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia
NCT05926765
Recruiting
This study will assess the efficacy and safety of bilateral intra-parotid administration of AAV2-hAQP1 in adults with Grade 2 or Grade 3 radiation-induced late xerostomia.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/03/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands
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A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors
NCT05150691
Recruiting
This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/02/2024
Locations: Holy Cross Hospital, Silver Spring, Maryland
Conditions: HER2-positive Advanced Solid Tumor
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Personalized Treatment in Thyroid Disorders
NCT03517579
Recruiting
The Collar Therapy Indicator (CoTI) (A device that is placed in collar around the neck resembling a turtle neck sweater collar with a wire and recording box) has been shown in a single small previously published experience to provide data regarding radioiodine exposure that correlates with conventional methods of measuring I-123 and I-131 uptakes after diagnostic dose administration and/or therapy for thyroid disorders. We hypothesize that the device's continuous measurement capability will perm... Read More
Gender:
ALL
Ages:
Between 21 years and 65 years
Trial Updated:
10/02/2024
Locations: Johns Hopkins Hospital, Baltimore, Maryland
Conditions: Thyroid Cancer, Graves Disease
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2321GCCC: CRD3874-SI in Patients with Relapsed/refractory AML
NCT06626633
Recruiting
This clinical research study is being done to answer questions about how to treat cancer. To clear cancer cells from the body, the immune system needs the action of proteins called Type 1 interferons. The protein STING (for STimulator of INterferon Genes) stimulates the body to make Type 1 interferons. Type 1 interferons activate key molecules in cancer immunity to kill cancer cells. CRD3874 is a synthetic drug that activates STING, and STING stimulates the immune system to kill cancer cells.... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
10/01/2024
Locations: University of Maryland, Baltimore, Baltimore, Maryland
Conditions: Acute Myeloid Leukemia
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Vaporized Cannabis Administration and Co-Administration of Alcohol on Impairment
NCT06293040
Recruiting
This human laboratory study will use cognitive, behavioral, and subjective measures to characterize impairment associated with co-use of alcohol and vaporized cannabis. Participants (n=32) will complete 7 double-blind, double-dummy outpatient sessions in randomized order. In each session, participants will self-administer placebo (0 mg THC) or active vaporized cannabis (5 or 25 mg THC, via a handheld vaporizer called the Mighty Medic) and a placebo drink (BAC 0.0%) or alcohol drink calculated to... Read More
Gender:
ALL
Ages:
21 years and above
Trial Updated:
09/30/2024
Locations: Johns Hopkins Behavioral Pharmacology Research Unit, Baltimore, Maryland
Conditions: Cannabis Intoxication, Alcohol Intoxication
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